Entity Details

Primary name TFPI1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10646
EntryNameTFPI1_HUMAN
FullNameTissue factor pathway inhibitor
TaxID9606
Evidenceevidence at protein level
Length304
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTFPI

GO terms

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GOName
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0007596 blood coagulation
GO:0009986 cell surface
GO:0030195 negative regulation of blood coagulation
GO:0031225 anchored component of membrane
GO:0032355 response to estradiol
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071383 cellular response to steroid hormone stimulus
GO:2000264 negative regulation of blood coagulation, extrinsic pathway

Subcellular Location

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Subcellular Location
Microsome membrane
Secreted

Domains

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DomainNameCategoryType
IPR002223 Pancreatic trypsin inhibitor Kunitz domainDomainDomain
IPR008296 Tissue factor pathway inhibitor-likeFamilyFamily
IPR020901 Proteinase inhibitor I2, Kunitz, conserved siteSiteConserved site
IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00036 Coagulation factor VIIa Recombinant HumanDrugbankbiotech
DB06779 DalteparinDrugbanksmall molecule
DB14562 Andexanet alfaDrugbankbiotech