Entity Details

Primary name THB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10828
EntryNameTHB_HUMAN
FullNameThyroid hormone receptor beta
TaxID9606
Evidenceevidence at protein level
Length461
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTHRB

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0002154 thyroid hormone mediated signaling pathway
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006351 transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007605 sensory perception of sound
GO:0007621 negative regulation of female receptivity
GO:0008016 regulation of heart contraction
GO:0008050 female courtship behavior
GO:0008270 zinc ion binding
GO:0009755 hormone-mediated signaling pathway
GO:0016604 nuclear body
GO:0019899 enzyme binding
GO:0030154 cell differentiation
GO:0031490 chromatin DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046549 retinal cone cell development
GO:0060509 type I pneumocyte differentiation
GO:0070324 thyroid hormone binding
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097474 retinal cone cell apoptotic process
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR001728 Thyroid hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00279 LiothyronineDrugbanksmall molecule
DB00451 LevothyroxineDrugbanksmall molecule
DB00509 DextrothyroxineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01583 LiotrixDrugbanksmall molecule
DB02106 [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic AcidDrugbanksmall molecule
DB03176 KB-141Drugbanksmall molecule
DB03181 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-DioneDrugbanksmall molecule
DB03604 TiratricolDrugbanksmall molecule
DB03788 GC-24Drugbanksmall molecule
DB05035 EprotiromeDrugbanksmall molecule
DB05192 MB07811Drugbanksmall molecule
DB07425 SobetiromeDrugbanksmall molecule
DB08085 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONEDrugbanksmall molecule
DB09100 Thyroid, porcineDrugbankbiotech

Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
THB_HUMANNCOA6_HUMANBioGRID, HPRD, IntAct10567404 10823961 10866662 11158331 11773444 details
THB_HUMANRXRA_HUMANBioGRID, HPRD, MINT15604093 19211732 19422879 7746322 9162076 9171239 9368056 9415406 9582446 details
THB_HUMANCNOT1_HUMANHPRD, MINT16778766 details
THB_HUMANMED25_HUMANMINT17641689 details
THB_HUMANADAT3_HUMANBioGRID, IntAct21988832 details
THB_HUMANNCOA3_HUMANBioGRID, HPRD, I2D15604093 20956942 9346901 details
THB_HUMANNCOR2_HUMANBioGRID, HPRD, I2D11518802 17242407 19211732 20956942 9415406 9751500 9878542 details
THB_HUMANNCOR1_HUMANBioGRID, HPRD, I2D11903058 12799135 14985366 15336696 16464943 17242407 19211732 20956942 25572392 7566114 9121466 details
THB_HUMANATF2_HUMANBioGRID, I2D20956942 details
THB_HUMANP85A_HUMANDIP16446424 details
THB_HUMANPRS8_HUMANBioGRID, HPRD15604093 7870181 9368056 details
THB_HUMANBRD8_HUMANBioGRID, HPRD9368056 details
THB_HUMANNCOA2_HUMANBioGRID, HPRD11435616 11518802 12612084 9920895 details
THB_HUMANNRBF2_HUMANBioGRID, HPRD10786636 details
THB_HUMANCCND1_HUMANBioGRID, HPRD12048199 details
THB_HUMANTBL1X_HUMANBioGRID10809664 17242407 details
THB_HUMANTRIP4_HUMANBioGRID, HPRD10454579 7776974 details
THB_HUMANANM1_HUMANBioGRID11050077 details
THB_HUMANTS101_HUMANBioGRID10508170 details
THB_HUMANP53_HUMANBioGRID, HPRD11258898 8633054 details
THB_HUMANPRGC2_HUMANBioGRID11733490 details
THB_HUMANPRGC1_HUMANBioGRID, HPRD11751919 details
THB_HUMANCSN2_HUMANBioGRID, HPRD10207062 7776974 details
THB_HUMANTHB_HUMANBioGRID, HPRD10567404 19422879 9162076 9751500 details
THB_HUMANNCOA1_HUMANBioGRID, HPRD10454579 11435616 12612084 15249124 15604093 23975195 9121466 9171239 9751500 details
THB_HUMANNR2F6_HUMANBioGRID, HPRD10713182 details
THB_HUMANSRC_HUMANBioGRID14985366 details
THB_HUMANLRIF1_HUMANBioGRID17455211 details
THB_HUMANPRKDC_HUMANBioGRID17242407 details
THB_HUMANHDAC3_HUMANBioGRID17242407 details
THB_HUMANKCC2B_HUMANBioGRID, HPRD15604093 details
THB_HUMANNRIP1_HUMANBioGRID, HPRD15604093 details
THB_HUMANHMGN3_HUMANBioGRID, HPRD15604093 details
THB_HUMANRXRG_HUMANBioGRID, HPRD15604093 9794455 details
THB_HUMANRXRB_HUMANBioGRID, HPRD15604093 details
THB_HUMANMED21_HUMANBioGRID, HPRD15249124 details
THB_HUMANROBO4_HUMANBioGRID14761960 details
THB_HUMANAN32A_HUMANBioGRID15308690 details
THB_HUMANC1D_HUMANBioGRID, HPRD9405624 details
THB_HUMANMMS19_HUMANBioGRID11279242 details
THB_HUMANRANB9_HUMANBioGRID16595702 details
THB_HUMANNSD1_HUMANBioGRID23975195 details
THB_HUMANUBC9_HUMANBioGRID22930759 details
THB_HUMANTRIP6_HUMANHPRD7776974 details
THB_HUMANZNHI3_HUMANHPRD7776974 details
THB_HUMANJHD2C_HUMANHPRD7776974 details
THB_HUMANCIP4_HUMANHPRD7776974 details
THB_HUMANTRIPC_HUMANHPRD7776974 details
THB_HUMANPCH2_HUMANHPRD7776974 details
THB_HUMANMECR_HUMANHPRD9795230 details
THB_HUMANHOP2_HUMANHPRD11739747 details
THB_HUMANACVR1_HUMANHPRD9267036 details
THB_HUMANRARA_HUMANHPRD17641689 details
THB_HUMANANM2_HUMANHPRD, IntAct12039952 details
THB_HUMANFMR1_HUMANIntAct31413325 details
THB_HUMANSMC1A_HUMANBioGRID17242407 details
THB_HUMANPARP1_HUMANBioGRID17242407 details
THB_HUMANDNLI3_HUMANBioGRID17242407 details
THB_HUMANXRCC5_HUMANBioGRID17242407 details
THB_HUMANXRCC6_HUMANBioGRID17242407 details
THB_HUMANHSP74_HUMANBioGRID17242407 details
THB_HUMANTBL1R_HUMANBioGRID17242407 details
THB_HUMANGPS2_HUMANBioGRID17242407 details
THB_HUMANIMA5_HUMANBioGRID31319097 details
THB_HUMANIMB1_HUMANBioGRID31319097 details
THB_HUMANCTCF_HUMANHPRD10625678 details
THB_HUMANMED1_HUMANHPRD9325263 details
THB_HUMANHDAC2_HUMANHPRD10508171 details
THB_HUMANBTG1_HUMANHPRD15674337 details
THB_HUMAN3MG_HUMANHPRD14761960 details
THB_HUMANESR1_HUMANHPRD9717844 details
THB_HUMANFOXO1_HUMANHPRD11353774 details