Entity Details

Primary name IRF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10914
EntryNameIRF1_HUMAN
FullNameInterferon regulatory factor 1
TaxID9606
Evidenceevidence at protein level
Length325
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesIRF1

GO terms

Show/Hide Table
GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0002819 regulation of adaptive immune response
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell population proliferation
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0045088 regulation of innate immune response
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001346 Interferon regulatory factor DNA-binding domainDomainDomain
IPR017431 Interferon regulatory factor-1/2FamilyFamily
IPR019817 Interferon regulatory factor, conserved siteSiteConserved site
IPR031215 Interferon regulatory factor 1FamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
IRF1_HUMANCDN1B_HUMANBioGRID, IntAct21988832 details
IRF1_HUMANSYQ_HUMANBioGRID, IntAct21988832 details
IRF1_HUMANSTAT1_HUMANBioGRID, HPRD, IntAct, NTNU10764778 16512786 17525742 19124747 8810328 details
IRF1_HUMANSUMO1_HUMANDIP17942705 details
IRF1_HUMANNF2L2_HUMANIntAct32911434 details
IRF1_HUMANIRF9_HUMANBioGRID, IntAct12799427 20211142 details
IRF1_HUMANKAT2B_HUMANBioGRID, HPRD10022868 11304541 23670564 details
IRF1_HUMANKAT2A_HUMANBioGRID10022868 details
IRF1_HUMANIRF8_HUMANBioGRID, HPRD11483597 7768900 9742224 details
IRF1_HUMANHMGA1_HUMANBioGRID, HPRD10357819 details
IRF1_HUMANEP300_HUMANBioGRID, HPRD10438822 14662860 15509808 23670564 details
IRF1_HUMANCBP_HUMANBioGRID9659924 details
IRF1_HUMANCHIP_HUMANBioGRID20947504 23134341 23729439 26330542 28362432 30042418 details
IRF1_HUMANTRAF3_HUMANBioGRID21903422 details
IRF1_HUMANKEAP1_HUMANBioGRID21903422 details
IRF1_HUMANNPM_HUMANBioGRID21245151 details
IRF1_HUMANYBOX1_HUMANBioGRID21245151 details
IRF1_HUMANTIF1B_HUMANBioGRID21245151 23134341 details
IRF1_HUMANSPI1_HUMANBioGRID11483597 9593745 details
IRF1_HUMANMDM2_HUMANBioGRID23134341 24583282 24721577 27795392 details
IRF1_HUMANSET_HUMANBioGRID23134341 details
IRF1_HUMANBIRC3_HUMANBioGRID24464131 29545793 details
IRF1_HUMANIRF2_HUMANBioGRID16982896 details
IRF1_HUMANXAF1_HUMANBioGRID30042418 details
IRF1_HUMANGSK3B_HUMANBioGRID30854564 details
IRF1_HUMANSPOP_HUMANBioGRID31776466 details
IRF1_HUMANULK2_HUMANIntAct17353931 details
IRF1_HUMANSMCA4_HUMANBioGRID, IntAct16195385 17182572 details
IRF1_HUMANIRF3_HUMANIntAct32878885 details
IRF1_HUMANSP2_HUMANBioGRID19482358 details
IRF1_HUMANHS90A_HUMANBioGRID23729439 details
IRF1_HUMANHS71A_HUMANBioGRID23729439 details
IRF1_HUMANHS71B_HUMANBioGRID23729439 details
IRF1_HUMANCBL_HUMANBioGRID21740303 details
IRF1_HUMANH31_HUMANBioGRID21740303 details
IRF1_HUMANPRDM1_HUMANBioGRID19828629 details
IRF1_HUMANTRAF6_HUMANBioGRID29545793 details
IRF1_HUMANFBXW7_HUMANBioGRID30854564 details
IRF1_HUMANUBE3A_HUMANBioGRID30690483 details
IRF1_HUMANNFKB1_HUMANHPRD8746784 details
IRF1_HUMANTF65_HUMANHPRD8746784 details