Entity Details

Primary name BIP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11021
EntryNameBIP_HUMAN
FullNameEndoplasmic reticulum chaperone BiP
TaxID9606
Evidenceevidence at protein level
Length654
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesHSPA5

GO terms

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GOName
GO:0001554 luteolysis
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005790 smooth endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006983 ER overload response
GO:0009986 cell surface
GO:0010976 positive regulation of neuron projection development
GO:0016020 membrane
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0021589 cerebellum structural organization
GO:0021680 cerebellar Purkinje cell layer development
GO:0021762 substantia nigra development
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030182 neuron differentiation
GO:0030335 positive regulation of cell migration
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0030496 midbody
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031072 heat shock protein binding
GO:0031204 posttranslational protein targeting to membrane, translocation
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032991 protein-containing complex
GO:0034620 cellular response to unfolded protein
GO:0034663 endoplasmic reticulum chaperone complex
GO:0034975 protein folding in endoplasmic reticulum
GO:0035437 maintenance of protein localization in endoplasmic reticulum
GO:0035690 cellular response to drug
GO:0036498 IRE1-mediated unfolded protein response
GO:0036499 PERK-mediated unfolded protein response
GO:0036500 ATF6-mediated unfolded protein response
GO:0042026 protein refolding
GO:0042149 cellular response to glucose starvation
GO:0042220 response to cocaine
GO:0042470 melanosome
GO:0043022 ribosome binding
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0044183 protein folding chaperone
GO:0045296 cadherin binding
GO:0051082 unfolded protein binding
GO:0051085 chaperone cofactor-dependent protein refolding
GO:0051087 chaperone binding
GO:0051402 neuron apoptotic process
GO:0051787 misfolded protein binding
GO:0060904 regulation of protein folding in endoplasmic reticulum
GO:0070062 extracellular exosome
GO:0071236 cellular response to antibiotic
GO:0071277 cellular response to calcium ion
GO:0071287 cellular response to manganese ion
GO:0071320 cellular response to cAMP
GO:0071353 cellular response to interleukin-4
GO:0071480 cellular response to gamma radiation
GO:0097501 stress response to metal ion
GO:1901998 toxin transport
GO:1903891 regulation of ATF6-mediated unfolded protein response
GO:1903894 regulation of IRE1-mediated unfolded protein response
GO:1903895 negative regulation of IRE1-mediated unfolded protein response
GO:1903897 regulation of PERK-mediated unfolded protein response
GO:1904313 response to methamphetamine hydrochloride
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Cell surface
Cytoplasm
Endoplasmic reticulum lumen
Melanosome

Domains

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DomainNameCategoryType
IPR013126 Heat shock protein 70 familyFamilyFamily
IPR018181 Heat shock protein 70, conserved siteSiteConserved site
IPR029047 Heat shock protein 70kD, peptide-binding domain superfamilyFamilyHomologous superfamily
IPR029048 Heat shock protein 70kD, C-terminal domain superfamilyFamilyHomologous superfamily
IPR042050 Endoplasmic reticulum chaperone BIP, nucleotide-binding domainDomainDomain
IPR043129 ATPase, nucleotide binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech

Interactions

203 interactions

InteractorPartnerSourcesPublicationsLink
BIP_HUMANGRB2_HUMANBioGRID, IntAct12577067 19380743 20936779 31980649 details
BIP_HUMANBCAR1_HUMANBioGRID, HPRD, IntAct16169070 details
BIP_HUMANDDX24_HUMANBioGRID, HPRD, IntAct16169070 details
BIP_HUMANPSME3_HUMANBioGRID, HPRD, IntAct16169070 details
BIP_HUMANDPYL5_HUMANHPRD, IntAct16169070 details
BIP_HUMANTMM62_HUMANHPRD, IntAct16169070 details
BIP_HUMANA2MG_HUMANBioGRID, HPRD, MINT12194978 17174955 details
BIP_HUMANMTR1B_HUMANBioGRID, HPRD, IntAct17215244 26514267 details
BIP_HUMANRAF1_HUMANBioGRID, IntAct18064632 details
BIP_HUMANDJB11_HUMANBioGRID, HPIDb, IntAct, MINT18923428 20335166 21217698 24189400 26085089 26186194 26344197 28514442 33957083 details
BIP_HUMANSH3B4_HUMANBioGRID, IntAct18654987 details
BIP_HUMANFCSD2_HUMANBioGRID, IntAct18654987 details
BIP_HUMANSNW1_HUMANBioGRID, IntAct, MINT, UniProt12840015 20467437 32814053 details
BIP_HUMANAPC_HUMANBioGRID, IntAct20936779 details
BIP_HUMANSRBP2_HUMANBioGRID, IntAct20936779 details
BIP_HUMANID2_HUMANBioGRID, IntAct21988832 26735018 details
BIP_HUMANK1C14_HUMANBioGRID, IntAct21988832 details
BIP_HUMANCPT1A_HUMANBioGRID, IntAct21988832 details
BIP_HUMANDMKN_HUMANMINT22735594 details
BIP_HUMANS61A1_HUMANBioGRID, MINT22796945 26085089 details
BIP_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
BIP_HUMANERBB2_HUMANBioGRID, IntAct24189400 31980649 details
BIP_HUMANDJC10_HUMANBioGRID, HPRD, IntAct12411443 18400946 24189400 33957083 details
BIP_HUMANSTMN1_HUMANBioGRID, HPRD, IntAct10197448 26496610 7724523 details
BIP_HUMANUBQL4_HUMANBioGRID, IntAct11162551 26496610 details
BIP_HUMANERN1_HUMANBioGRID, DIP, HPRD, IntAct12637535 21118962 26551274 27238082 32149426 details
BIP_HUMANSIL1_HUMANBioGRID, HPRD, IntAct, MINT12356756 24473200 25877869 28514442 29323281 31258504 details
BIP_HUMANA4_HUMANBioGRID, IntAct, UniProt30664241 32814053 33957083 details
BIP_HUMANHMGB1_HUMANBioGRID, UniProt29721183 details
BIP_HUMANGUSP1_HUMANIntAct32814053 details
BIP_HUMANTT23L_HUMANIntAct32814053 details
BIP_HUMANBRPF3_HUMANIntAct32814053 details
BIP_HUMANLAT2_HUMANIntAct32814053 details
BIP_HUMANUB2V1_HUMANIntAct32814053 details
BIP_HUMANHPBP1_HUMANBioGRID, HPRD, MINT19659607 24473200 details
BIP_HUMANDPH1_HUMANBioGRID, HPRD11013075 details
BIP_HUMANT132A_HUMANBioGRID, HPRD12514190 details
BIP_HUMANK2C8_HUMANBioGRID, HPRD9409741 details
BIP_HUMANTHYG_HUMANBioGRID, HPRD10049727 11294872 details
BIP_HUMANUCHL5_HUMANBioGRID21800051 details
BIP_HUMANRPN1_HUMANBioGRID10588643 33957083 details
BIP_HUMANUBC_HUMANBioGRID23314748 27182664 details
BIP_HUMANAPRIO_HUMANBioGRID10970892 details
BIP_HUMANPRIO_HUMANBioGRID, HPRD10970892 15146195 details
BIP_HUMANMT21A_HUMANBioGRID23349634 details
BIP_HUMANVHL_HUMANBioGRID22234250 details
BIP_HUMANBIP_HUMANBioGRID24189400 29323281 details
BIP_HUMANUBE3A_HUMANBioGRID26506232 details
BIP_HUMANSQSTM_HUMANBioGRID26075355 29507222 29669822 29976090 30120248 31375263 details
BIP_HUMANDNJC1_HUMANBioGRID, HPRD10777498 26085089 33957083 details
BIP_HUMANSEC63_HUMANBioGRID26085089 33957083 details
BIP_HUMANDNJC3_HUMANBioGRID26085089 33957083 details
BIP_HUMANSPB5_HUMANBioGRID16049007 details
BIP_HUMANPARK7_HUMANBioGRID29976090 details
BIP_HUMANSHPS1_HUMANBioGRID19299420 details
BIP_HUMANPTN11_HUMANBioGRID19299420 details
BIP_HUMANMATK_HUMANBioGRID19299420 details
BIP_HUMANPTPRF_HUMANBioGRID25458010 details
BIP_HUMANBAG3_HUMANBioGRID24080088 details
BIP_HUMANOTUD3_HUMANBioGRID31266968 details
BIP_HUMANERPG3_HUMANBioGRID31722399 details
BIP_HUMANERCC6_HUMANBioGRID31722399 details
BIP_HUMANSUMO2_HUMANBioGRID32786267 details
BIP_HUMANOGT1_HUMANBioGRID32994395 details
BIP_HUMANM3K8_HUMANIntAct14743216 details
BIP_HUMANREL_HUMANIntAct14743216 details
BIP_HUMANIKBA_HUMANIntAct14743216 details
BIP_HUMANIKBB_HUMANIntAct14743216 details
BIP_HUMANIKBE_HUMANIntAct14743216 details
BIP_HUMANIKKB_HUMANIntAct14743216 details
BIP_HUMANNEMO_HUMANIntAct14743216 details
BIP_HUMANTANK_HUMANIntAct14743216 details
BIP_HUMANM3K1_HUMANIntAct14743216 details
BIP_HUMANM3K3_HUMANIntAct14743216 details
BIP_HUMANNFKB2_HUMANIntAct14743216 details
BIP_HUMANM3K14_HUMANIntAct14743216 details
BIP_HUMANTF65_HUMANBioGRID, IntAct14743216 25331947 details
BIP_HUMANRELB_HUMANIntAct14743216 details
BIP_HUMANRIPK1_HUMANIntAct14743216 details
BIP_HUMANRIPK3_HUMANIntAct14743216 details
BIP_HUMANTAB1_HUMANIntAct14743216 details
BIP_HUMANTAB2_HUMANIntAct14743216 details
BIP_HUMANM3K7_HUMANIntAct14743216 details
BIP_HUMANTBK1_HUMANIntAct14743216 details
BIP_HUMANTNR1A_HUMANIntAct14743216 details
BIP_HUMANTNR1B_HUMANIntAct14743216 details
BIP_HUMANTRAF2_HUMANIntAct14743216 details
BIP_HUMANTRAF6_HUMANIntAct14743216 details
BIP_HUMANEGFR_HUMANBioGRID, IntAct12471035 15657067 23956138 24189400 28065597 details
BIP_HUMANE2AK3_HUMANBioGRID, HPRD, IntAct11907036 20371724 26472337 27187154 27238082 28534368 details
BIP_HUMAN1433Z_HUMANMINT15161933 details
BIP_HUMANP53_HUMANBioGRID, MINT17184779 23443559 31152661 32807901 details
BIP_HUMANPTEN_HUMANIntAct18064632 details
BIP_HUMANPAWR_HUMANBioGRID, HPRD, IntAct19632185 details
BIP_HUMANCASP8_HUMANIntAct19632185 details
BIP_HUMANCAV1_HUMANIntAct19632185 details
BIP_HUMANHFE_HUMANMINT20618438 details
BIP_HUMANMLP3A_HUMANBioGRID, IntAct20562859 22963397 details
BIP_HUMANAKT1_HUMANBioGRID, IntAct16027165 21445305 32164484 details
BIP_HUMANVIME_HUMANBioGRID, IntAct27173435 unassigned1312 details
BIP_HUMANMARE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
BIP_HUMANATF6A_HUMANIntAct27238082 details
BIP_HUMANTAU_HUMANBioGRID, UniProt22460328 26269332 details
BIP_HUMANHNRH3_HUMANBioGRID, IntAct24189400 30021884 details
BIP_HUMANCC168_HUMANIntAct30021884 details
BIP_HUMANFMR1_HUMANIntAct31413325 details
BIP_HUMANCASS4_HUMANIntAct31413325 details
BIP_HUMANAPOB_HUMANBioGRID, HPRD, IntAct12397072 19164805 details
BIP_HUMANTCRG1_HUMANBioGRID, HPRD15456888 details
BIP_HUMANLPH_HUMANBioGRID, HPRD11751874 details
BIP_HUMANCASP7_HUMANBioGRID, HPRD11943137 24080088 details
BIP_HUMANCASPC_HUMANBioGRID11943137 details
BIP_HUMANVWF_HUMANBioGRID, HPRD10887119 details
BIP_HUMANTSHR_HUMANBioGRID, HPRD12383251 details
BIP_HUMANHLAC_HUMANBioGRID, HPRD7957306 details
BIP_HUMANLDLR_HUMANBioGRID, HPRD10906332 16257961 details
BIP_HUMANH2AX_HUMANBioGRID16522924 details
BIP_HUMANAIRE_HUMANBioGRID15150263 23443559 details
BIP_HUMANHDAC6_HUMANBioGRID20371724 23703321 details
BIP_HUMANDNMT1_HUMANBioGRID21745816 details
BIP_HUMANCBL_HUMANBioGRID19380743 21203488 details
BIP_HUMANTYY1_HUMANBioGRID17721549 details
BIP_HUMANDGCR8_HUMANBioGRID17765891 details
BIP_HUMANHDAC5_HUMANBioGRID21081666 details
BIP_HUMANSYVN1_HUMANBioGRID21903092 details
BIP_HUMANAMFR_HUMANBioGRID21343306 25301734 26119938 details
BIP_HUMANPSA3_HUMANBioGRID22079093 30009671 details
BIP_HUMANRN146_HUMANBioGRID21825151 details
BIP_HUMANOS9_HUMANBioGRID18264092 18502753 23097496 details
BIP_HUMANERLEC_HUMANBioGRID18264092 21118962 details
BIP_HUMANPP1G_HUMANBioGRID17683050 details
BIP_HUMANPSA2_HUMANBioGRID19193609 details
BIP_HUMANKCND3_HUMANBioGRID17725712 details
BIP_HUMANPWP1_HUMANBioGRID20028516 details
BIP_HUMANMKS3_HUMANBioGRID19815549 details
BIP_HUMANPSPC_HUMANBioGRID18400946 details
BIP_HUMANDNJB9_HUMANBioGRID18400946 details
BIP_HUMANASGR1_HUMANBioGRID23233672 details
BIP_HUMANSSRA_HUMANBioGRID17380188 details
BIP_HUMANCADH1_HUMANBioGRID16212417 25468996 details
BIP_HUMANCMKMT_HUMANBioGRID23349634 details
BIP_HUMANEF2KT_HUMANBioGRID23349634 details
BIP_HUMANMET18_HUMANBioGRID23349634 details
BIP_HUMANETKMT_HUMANBioGRID23349634 details
BIP_HUMANEFMT3_HUMANBioGRID23349634 details
BIP_HUMANMT21C_HUMANBioGRID23349634 details
BIP_HUMANMET22_HUMANBioGRID23349634 details
BIP_HUMANMET23_HUMANBioGRID23349634 details
BIP_HUMANZSWM7_HUMANBioGRID21965664 details
BIP_HUMANPAK2_HUMANBioGRID15908432 details
BIP_HUMANNCK1_HUMANBioGRID15908432 details
BIP_HUMANAICDA_HUMANBioGRID23277564 details
BIP_HUMANPK3C3_HUMANBioGRID23569248 details
BIP_HUMANTOPB1_HUMANBioGRID24239288 details
BIP_HUMANTRAP1_HUMANBioGRID24113185 details
BIP_HUMANHLAB_HUMANBioGRID24155957 details
BIP_HUMANGFAP_HUMANBioGRID24189400 details
BIP_HUMANHNRH1_HUMANBioGRID24189400 26760575 details
BIP_HUMANACTB_HUMANBioGRID24189400 31536960 details
BIP_HUMANRL23_HUMANBioGRID24189400 details
BIP_HUMANACTG_HUMANBioGRID24189400 details
BIP_HUMANHNRPU_HUMANBioGRID24189400 26344197 details
BIP_HUMANEWS_HUMANBioGRID24189400 details
BIP_HUMANCLUS_HUMANBioGRID22689054 23457489 details
BIP_HUMANGPX7_HUMANBioGRID23123197 details
BIP_HUMANEP300_HUMANBioGRID25301734 28947141 details
BIP_HUMANA1AT_HUMANBioGRID24899641 details
BIP_HUMANNCOA1_HUMANBioGRID16051665 details
BIP_HUMANPRDM1_HUMANBioGRID26823144 details
BIP_HUMANU2AF2_HUMANBioGRID26641092 details
BIP_HUMANSE1L1_HUMANBioGRID27030672 details
BIP_HUMANGLIP1_HUMANBioGRID23333597 details
BIP_HUMANUBE2S_HUMANBioGRID27593939 details
BIP_HUMANDDIT3_HUMANBioGRID28947141 details
BIP_HUMANGSK3B_HUMANBioGRID22460328 30711629 details
BIP_HUMANAGR2_HUMANBioGRID30575818 31436131 details
BIP_HUMANBECN1_HUMANBioGRID29669822 details
BIP_HUMANKCD15_HUMANBioGRID29665387 details
BIP_HUMANCXB1_HUMANBioGRID30737405 details
BIP_HUMANRAC3_HUMANBioGRID28534368 details
BIP_HUMANARAF_HUMANBioGRID29777862 details
BIP_HUMANWASF3_HUMANBioGRID27187154 details
BIP_HUMANMRP6_HUMANBioGRID29704455 details
BIP_HUMANTNR6_HUMANBioGRID18787411 details
BIP_HUMANEIF3D_HUMANBioGRID31669222 details
BIP_HUMANIFI6_HUMANBioGRID30224801 details
BIP_HUMANINS_HUMANBioGRID32457219 details
BIP_HUMANPRDX4_HUMANBioGRID32457219 33957083 details
BIP_HUMANANDR_HUMANBioGRID32206096 32814769 details
BIP_HUMANSIAH2_HUMANBioGRID32206096 details
BIP_HUMANACE2_HUMANBioGRID888800000195 details
BIP_HUMANDTNA_HUMANBioGRID20111909 details
BIP_HUMANERP29_HUMANBioGRID, HPRD33957083 9492298 details
BIP_HUMANUBE2T_HUMANBioGRID32491994 details
BIP_HUMANUCHL1_HUMANBioGRID32606430 details
BIP_HUMANIGHM_HUMANHPRD3122216 details
BIP_HUMANSUMO4_HUMANHPRD16236267 details
BIP_HUMANSVIL_HUMANHPRD16880273 details
BIP_HUMANGRIA1_HUMANHPRD10461883 details
BIP_HUMANK1C18_HUMANHPRD9409741 details
BIP_HUMANFA8_HUMANHPRD9305856 details
BIP_HUMANPCSK7_HUMANHPRD10964928 details
BIP_HUMAN5HT3A_HUMANHPRD12359150 details