Entity Details

Primary name TOP2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11388
EntryNameTOP2A_HUMAN
FullNameDNA topoisomerase 2-alpha
TaxID9606
Evidenceevidence at protein level
Length1531
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTOP2A

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000712 resolution of meiotic recombination intermediates
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0000819 sister chromatid segregation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006265 DNA topological change
GO:0006266 DNA ligation
GO:0006974 cellular response to DNA damage stimulus
GO:0007059 chromosome segregation
GO:0007143 female meiotic nuclear division
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0008301 DNA binding, bending
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0019899 enzyme binding
GO:0030263 apoptotic chromosome condensation
GO:0032991 protein-containing complex
GO:0040016 embryonic cleavage
GO:0042752 regulation of circadian rhythm
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043130 ubiquitin binding
GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048511 rhythmic process
GO:1905463 negative regulation of DNA duplex unwinding
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001241 DNA topoisomerase, type IIAFamilyFamily
IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminalDomainDomain
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR006171 TOPRIM domainDomainDomain
IPR012542 DTHCTDomainDomain
IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2DomainDomain
IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-betaFamilyHomologous superfamily
IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminalFamilyHomologous superfamily
IPR013760 DNA topoisomerase, type IIA-like domain superfamilyFamilyHomologous superfamily
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR018522 DNA topoisomerase, type IIA, conserved siteSiteConserved site
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR031660 C-terminal associated domain of TOPRIMDomainDomain
IPR034157 DNA topoisomerase 2, TOPRIM domainDomainDomain
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00218 MoxifloxacinDrugbanksmall molecule
DB00276 AmsacrineDrugbanksmall molecule
DB00380 DexrazoxaneDrugbanksmall molecule
DB00385 ValrubicinDrugbanksmall molecule
DB00444 TeniposideDrugbanksmall molecule
DB00445 EpirubicinDrugbanksmall molecule
DB00467 EnoxacinDrugbanksmall molecule
DB00487 PefloxacinDrugbanksmall molecule
DB00537 CiprofloxacinDrugbanksmall molecule
DB00685 TrovafloxacinDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00970 DactinomycinDrugbanksmall molecule
DB00978 LomefloxacinDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01059 NorfloxacinDrugbanksmall molecule
DB01165 OfloxacinDrugbanksmall molecule
DB01177 IdarubicinDrugbanksmall molecule
DB01179 PodofiloxDrugbanksmall molecule
DB01204 MitoxantroneDrugbanksmall molecule
DB01208 SparfloxacinDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB04576 FleroxacinDrugbanksmall molecule
DB04967 LucanthoneDrugbanksmall molecule
DB04975 BanoxantroneDrugbanksmall molecule
DB04978 SP1049CDrugbanksmall molecule
DB05022 AmonafideDrugbanksmall molecule
DB05129 ElsamitrucinDrugbanksmall molecule
DB05706 13-deoxydoxorubicinDrugbanksmall molecule
DB05920 RTA 744Drugbanksmall molecule
DB06013 AldoxorubicinDrugbanksmall molecule
DB06042 ZEN-012Drugbanksmall molecule
DB06263 AmrubicinDrugbanksmall molecule
DB06362 BecatecarinDrugbanksmall molecule
DB06420 AnnamycinDrugbanksmall molecule
DB06421 DeclopramideDrugbanksmall molecule
DB09047 FinafloxacinDrugbanksmall molecule

Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
TOP2A_HUMANCTNB1_HUMANBioGRID, IntAct16230076 17983804 27684187 details
TOP2A_HUMANCSK21_HUMANBioGRID, HPRD, IntAct11940573 21254166 22113938 26344197 8939955 9804834 details
TOP2A_HUMANKPCD_HUMANIntAct16611985 details
TOP2A_HUMANJUN_HUMANBioGRID, HPRD, MINT25609649 8387155 details
TOP2A_HUMANBRCA1_HUMANBioGRID, DIP, HPRD15965487 25184681 details
TOP2A_HUMANHDAC1_HUMANBioGRID, HPRD11062478 11136718 details
TOP2A_HUMANTOP2B_HUMANBioGRID, HPRD22939629 8710863 details
TOP2A_HUMANP53_HUMANBioGRID, HPRD10666337 32807901 details
TOP2A_HUMANDFFB_HUMANBioGRID, HPRD10959840 details
TOP2A_HUMANCDT1_HUMANBioGRID18162579 details
TOP2A_HUMANMK01_HUMANBioGRID10207078 details
TOP2A_HUMANCSN5_HUMANBioGRID15126503 21254166 details
TOP2A_HUMANKPCA_HUMANBioGRID, HPRD12569090 7499337 details
TOP2A_HUMANKPCB_HUMANBioGRID, HPRD12569090 7499337 details
TOP2A_HUMANKPCG_HUMANBioGRID, HPRD12569090 7499337 details
TOP2A_HUMANUBC9_HUMANBioGRID10862613 19596686 details
TOP2A_HUMANPIAS4_HUMANBioGRID20696768 details
TOP2A_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
TOP2A_HUMANUHRF1_HUMANBioGRID25451918 details
TOP2A_HUMANPLK1_HUMANBioGRID18695677 details
TOP2A_HUMANRN168_HUMANBioGRID27558965 details
TOP2A_HUMANSMUF2_HUMANBioGRID28611047 details
TOP2A_HUMANFBX28_HUMANBioGRID27754753 details
TOP2A_HUMANMDM4_HUMANBioGRID30672125 details
TOP2A_HUMANPIN1_HUMANBioGRID, HPRD, MINT11940573 details
TOP2A_HUMANRBP2_HUMANBioGRID, IntAct18394993 26344197 details
TOP2A_HUMANXRCC5_HUMANBioGRID, IntAct12393188 20085707 details
TOP2A_HUMANFOXM1_HUMANDIP15965487 details
TOP2A_HUMANXPO1_HUMANDIP, HPRD12821127 19955415 details
TOP2A_HUMANARI1A_HUMANDIP23698369 details
TOP2A_HUMANSMCA4_HUMANDIP23698369 details
TOP2A_HUMANDHX9_HUMANBioGRID, HPRD12711669 15034300 details
TOP2A_HUMANHDAC2_HUMANBioGRID, HPRD11062478 details
TOP2A_HUMAN1433E_HUMANBioGRID, HPRD10788521 details
TOP2A_HUMANCDC5L_HUMANBioGRID11101529 20467437 details
TOP2A_HUMANNR4A1_HUMANBioGRID19321449 details
TOP2A_HUMANSETMR_HUMANBioGRID18790802 19458360 details
TOP2A_HUMANH31_HUMANBioGRID20504901 34079125 details
TOP2A_HUMANH33_HUMANBioGRID20504901 details
TOP2A_HUMANBMI1_HUMANBioGRID19956605 details
TOP2A_HUMANRING1_HUMANBioGRID19956605 details
TOP2A_HUMANCTCF_HUMANBioGRID14759373 details
TOP2A_HUMANSMRCD_HUMANBioGRID21549307 details
TOP2A_HUMANCUL2_HUMANBioGRID19695223 details
TOP2A_HUMANELOC_HUMANBioGRID19695223 details
TOP2A_HUMANVHL_HUMANBioGRID19695223 details
TOP2A_HUMANFBXW7_HUMANBioGRID21254166 details
TOP2A_HUMANGSK3B_HUMANBioGRID21254166 details
TOP2A_HUMANBLM_HUMANBioGRID19329795 details
TOP2A_HUMANTERF2_HUMANBioGRID19329795 details
TOP2A_HUMANRB_HUMANBioGRID, HPRD10393912 details
TOP2A_HUMANSRPK1_HUMANBioGRID, HPRD15034300 details
TOP2A_HUMANITA4_HUMANBioGRID22623428 details
TOP2A_HUMANRAC1_HUMANBioGRID19961560 details
TOP2A_HUMANKMT2E_HUMANBioGRID26678539 details
TOP2A_HUMANAHSA1_HUMANBioGRID22504172 details
TOP2A_HUMANERPG3_HUMANBioGRID26030138 details
TOP2A_HUMANERCC6_HUMANBioGRID26030138 details
TOP2A_HUMANTOP2A_HUMANBioGRID9972548 details
TOP2A_HUMANMRE11_HUMANBioGRID31967940 details
TOP2A_HUMANCDK1_HUMANHPRD12569090 7635160 details
TOP2A_HUMANSUMO4_HUMANHPRD16236267 details
TOP2A_HUMANSUMO1_HUMANHPRD10862613 12832072 details