Entity Details

Primary name PYC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11498
EntryNamePYC_HUMAN
FullNamePyruvate carboxylase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length1178
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesPC

GO terms

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GOName
GO:0004736 pyruvate carboxylase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis
GO:0006629 lipid metabolic process
GO:0006768 biotin metabolic process
GO:0009374 biotin binding
GO:0010629 negative regulation of gene expression
GO:0019074 viral RNA genome packaging
GO:0042802 identical protein binding
GO:0044791 positive regulation by host of viral release from host cell
GO:0044794 positive regulation by host of viral process
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR000089 Biotin/lipoyl attachmentDomainDomain
IPR000891 Pyruvate carboxyltransferaseDomainDomain
IPR001882 Biotin-binding siteSiteBinding site
IPR003379 Carboxylase, conserved domainDomainDomain
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domainDomainDomain
IPR005481 Biotin carboxylase-like, N-terminal domainDomainDomain
IPR005482 Biotin carboxylase, C-terminalDomainDomain
IPR005930 Pyruvate carboxylaseFamilyFamily
IPR011053 Single hybrid motifFamilyHomologous superfamily
IPR011054 Rudiment single hybrid motifFamilyHomologous superfamily
IPR011761 ATP-grasp foldDomainDomain
IPR011764 Biotin carboxylation domainDomainDomain
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR016185 Pre-ATP-grasp domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00119 Pyruvic acidDrugbanksmall molecule
DB00121 BiotinDrugbanksmall molecule
DB07497 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanalDrugbanksmall molecule