Entity Details

Primary name MPRI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11717
EntryNameMPRI_HUMAN
FullNameCation-independent mannose-6-phosphate receptor
TaxID9606
Evidenceevidence at protein level
Length2491
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesIGF2R

GO terms

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GOName
GO:0001889 liver development
GO:0001965 G-protein alpha-subunit binding
GO:0001972 retinoic acid binding
GO:0005010 insulin-like growth factor-activated receptor activity
GO:0005520 insulin-like growth factor binding
GO:0005537 mannose binding
GO:0005641 nuclear envelope lumen
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006898 receptor-mediated endocytosis
GO:0007041 lysosomal transport
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007283 spermatogenesis
GO:0009791 post-embryonic development
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0019899 enzyme binding
GO:0030118 clathrin coat
GO:0030133 transport vesicle
GO:0030139 endocytic vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0030667 secretory granule membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031100 animal organ regeneration
GO:0031995 insulin-like growth factor II binding
GO:0032526 response to retinoic acid
GO:0032588 trans-Golgi network membrane
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0044794 positive regulation by host of viral process
GO:0048471 perinuclear region of cytoplasm
GO:0051219 phosphoprotein binding
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:1904772 response to tetrachloromethane
GO:1905394 retromer complex binding

Subcellular Location

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Subcellular Location
Endosome membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR000479 Cation-independent mannose-6-phosphate receptor repeatRepeatRepeat
IPR000562 Fibronectin type II domainDomainDomain
IPR009011 Mannose-6-phosphate receptor binding domain superfamilyFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR036943 Fibronectin type II domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01277 MecaserminDrugbankbiotech
DB02900 alpha-D-mannose 6-phosphateDrugbanksmall molecule
DB13173 Cerliponase alfaDrugbankbiotech
DB14751 Mecasermin rinfabateDrugbankbiotech

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
MPRI_HUMANGGA1_HUMANBioGRID, HPRD, I2D, MINT11387475 11390366 11859375 11859376 12060753 14567678 15117318 20676133 details
MPRI_HUMANGGA2_HUMANBioGRID, HPRD, MINT11387475 11387476 11390366 11859375 14567678 29358589 31076515 details
MPRI_HUMANGGA3_HUMANBioGRID, HPRD, MINT11387475 11390366 11859375 12032548 12060753 14567678 16135791 16977309 details
MPRI_HUMANPACS1_HUMANHPRD, MINT11331585 16977309 9695949 details
MPRI_HUMANIGF2_HUMANDIP, HPRD, MINT17850746 18046459 7797478 9722981 details
MPRI_HUMANATX1_HUMANBioGRID, IntAct23275563 details
MPRI_HUMANVPS35_HUMANUniProt15078903 details
MPRI_HUMANCREG1_HUMANBioGRID, HPRD12934103 details
MPRI_HUMANPLIN3_HUMANBioGRID, HPRD10908666 9590177 details
MPRI_HUMANUPAR_HUMANBioGRID9566979 details
MPRI_HUMANCSK21_HUMANBioGRID12060753 details
MPRI_HUMANTRAF6_HUMANIntAct17353931 details
MPRI_HUMANEEA1_HUMANBioGRID, IntAct, MINT16977309 29568061 details
MPRI_HUMANTGON2_HUMANBioGRID, IntAct, MINT16977309 29568061 details
MPRI_HUMANMPRI_HUMANHPRD, MINT11387476 22681933 details
MPRI_HUMANVP26A_HUMANUniProt15078903 details
MPRI_HUMANABCE1_HUMANBioGRID25659154 details
MPRI_HUMANMD2L2_HUMANBioGRID30022168 details
MPRI_HUMANATG9A_HUMANBioGRID29156099 details
MPRI_HUMANMARCS_HUMANBioGRID30942445 34079125 details
MPRI_HUMANST7_HUMANBioGRID29395067 details
MPRI_HUMANGRRE1_HUMANBioGRID29395067 details
MPRI_HUMANCATD_HUMANHPRD15258139 details
MPRI_HUMANGRAB_HUMANHPRD11081635 details
MPRI_HUMANUROK_HUMANHPRD9566979 details
MPRI_HUMANASPG_HUMANHPRD9362483 details