Entity Details

Primary name ACTN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12814
EntryNameACTN1_HUMAN
FullNameAlpha-actinin-1
TaxID9606
Evidenceevidence at protein level
Length892
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesACTN1

GO terms

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GOName
GO:0001725 stress fiber
GO:0001726 ruffle
GO:0002576 platelet degranulation
GO:0003725 double-stranded RNA binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0005911 cell-cell junction
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0007015 actin filament organization
GO:0017166 vinculin binding
GO:0030018 Z disc
GO:0030220 platelet formation
GO:0030374 nuclear receptor coactivator activity
GO:0031093 platelet alpha granule lumen
GO:0031143 pseudopodium
GO:0036344 platelet morphogenesis
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0042995 cell projection
GO:0044325 transmembrane transporter binding
GO:0048041 focal adhesion assembly
GO:0051015 actin filament binding
GO:0051017 actin filament bundle assembly
GO:0051271 negative regulation of cellular component movement
GO:0051639 actin filament network formation
GO:0070062 extracellular exosome
GO:0098978 glutamatergic synapse
GO:0099186 structural constituent of postsynapse

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014837 EF-hand, Ca insensitiveDomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06773 Human calcitoninDrugbankbiotech
DB09130 CopperDrugbanksmall molecule

Interactions

120 interactions

InteractorPartnerSourcesPublicationsLink
ACTN1_HUMANKCC2A_HUMANBioGRID, IntAct, MINT12223541 25241761 details
ACTN1_HUMANXRCC4_HUMANBioGRID, HPRD, IntAct16189514 details
ACTN1_HUMANMAGAB_HUMANBioGRID, HPRD, IntAct16189514 details
ACTN1_HUMANMYOZ1_HUMANBioGRID, HPRD, IntAct11842093 16189514 32296183 details
ACTN1_HUMANATX2_HUMANBioGRID, HPRD, IntAct16713569 details
ACTN1_HUMANCOIL_HUMANBioGRID, HPRD, IntAct16713569 details
ACTN1_HUMANFRDA_HUMANBioGRID, HPRD, IntAct16713569 details
ACTN1_HUMANGFI1B_HUMANBioGRID, HPRD, IntAct16713569 details
ACTN1_HUMANPTN1_HUMANHPRD, IntAct16291744 details
ACTN1_HUMANPSN1_HUMANBioGRID, IntAct21163940 details
ACTN1_HUMANAPC_HUMANBioGRID, IntAct20936779 details
ACTN1_HUMANATX7_HUMANBioGRID, IntAct21078624 details
ACTN1_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
ACTN1_HUMANGIT2_HUMANBioGRID, IntAct21988832 details
ACTN1_HUMANNUMBL_HUMANBioGRID, IntAct21988832 details
ACTN1_HUMANTF2H1_HUMANBioGRID, IntAct21988832 details
ACTN1_HUMANIMA1_HUMANBioGRID, IntAct21988832 details
ACTN1_HUMANPIAS4_HUMANBioGRID, IntAct21988832 details
ACTN1_HUMANPSA1_HUMANBioGRID, IntAct21988832 details
ACTN1_HUMANRS27_HUMANBioGRID, IntAct21988832 details
ACTN1_HUMANODPX_HUMANBioGRID, IntAct21988832 details
ACTN1_HUMANZYX_HUMANBioGRID, HPRD, mbinfo10224105 11423549 details
ACTN1_HUMANACTN1_HUMANBioGRID, HPRD, IntAct, mbinfo11423549 11470434 11573089 12223541 25416956 details
ACTN1_HUMANTITIN_HUMANBioGRID, HPRD, mbinfo11101506 11305911 11846417 9501083 details
ACTN1_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
ACTN1_HUMANOAS1_HUMANBioGRID, IntAct25416956 25910212 31515488 details
ACTN1_HUMANCBY2_HUMANBioGRID, IntAct25416956 details
ACTN1_HUMANKCTD6_HUMANBioGRID, IntAct25416956 details
ACTN1_HUMANMYOZ2_HUMANBioGRID, HPRD, IntAct11842093 25416956 25910212 32296183 details
ACTN1_HUMANEPMIP_HUMANBioGRID, IntAct25416956 32296183 details
ACTN1_HUMANMILK2_HUMANBioGRID, IntAct25416956 32296183 details
ACTN1_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
ACTN1_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
ACTN1_HUMANSCRIB_HUMANMINT24550280 details
ACTN1_HUMANCN119_HUMANBioGRID, IntAct32296183 details
ACTN1_HUMANSYP2L_HUMANBioGRID, IntAct32296183 details
ACTN1_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
ACTN1_HUMANDYLT1_HUMANBioGRID, IntAct32296183 details
ACTN1_HUMANUBP2_HUMANBioGRID, IntAct32296183 details
ACTN1_HUMANPDLI4_HUMANIntAct32296183 details
ACTN1_HUMANGA45G_HUMANBioGRID, IntAct32296183 details
ACTN1_HUMANNKAP1_HUMANBioGRID, IntAct32296183 details
ACTN1_HUMANACTN3_HUMANBioGRID, IntAct25416956 32296183 details
ACTN1_HUMANAPBP2_HUMANBioGRID, IntAct32296183 details
ACTN1_HUMANIF2A_HUMANBioGRID, IntAct32296183 details
ACTN1_HUMANTHIO_HUMANBioGRID, IntAct32296183 details
ACTN1_HUMANACTN2_HUMANBioGRID, IntAct22939629 25910212 details
ACTN1_HUMANPDLI1_HUMANBioGRID, HPRD, IntAct10753915 11110697 11973348 26186194 28514442 details
ACTN1_HUMANGLCNE_HUMANIntAct18560563 details
ACTN1_HUMANADIP_HUMANBioGRID, HPRD12446711 details
ACTN1_HUMANITB1_HUMANBioGRID2116421 details
ACTN1_HUMANPKN1_HUMANBioGRID, HPRD11802708 9030526 details
ACTN1_HUMANCOHA1_HUMANBioGRID, HPRD11739652 details
ACTN1_HUMANMYOTI_HUMANBioGRID, HPRD10369880 12499399 26871637 details
ACTN1_HUMANPYGB_HUMANBioGRID, HPRD12211109 details
ACTN1_HUMANCD5R1_HUMANBioGRID, HPRD12223541 details
ACTN1_HUMANCD5R2_HUMANBioGRID, HPRD12223541 details
ACTN1_HUMANGIPC1_HUMANBioGRID, HPRD10198040 details
ACTN1_HUMANKAT2B_HUMANBioGRID, HPRD15604093 details
ACTN1_HUMANMED14_HUMANBioGRID, HPRD15604093 details
ACTN1_HUMANNR1H3_HUMANBioGRID, HPRD15604093 details
ACTN1_HUMANTBA1A_HUMANBioGRID18341635 details
ACTN1_HUMANDAG1_HUMANBioGRID18341635 details
ACTN1_HUMANDEND_HUMANBioGRID16464232 details
ACTN1_HUMANPALLD_HUMANBioGRID, HPRD15147863 16125169 details
ACTN1_HUMANSRBS2_HUMANBioGRID16125169 details
ACTN1_HUMANM3K1_HUMANBioGRID14581471 details
ACTN1_HUMANMTAP2_HUMANBioGRID2777757 details
ACTN1_HUMANCLUS_HUMANBioGRID17974975 details
ACTN1_HUMANCSRP1_HUMANBioGRID, HPRD10926853 details
ACTN1_HUMANERBIN_HUMANBioGRID15123239 details
ACTN1_HUMANDDIAS_HUMANBioGRID28079882 details
ACTN1_HUMANSHPS1_HUMANBioGRID19299420 details
ACTN1_HUMANGRM5_HUMANBioGRID17311919 details
ACTN1_HUMANICAM5_HUMANBioGRID16820411 details
ACTN1_HUMANGRIA4_HUMANHPRD16190873 details
ACTN1_HUMANLPP_HUMANHPRD12615977 details
ACTN1_HUMANAA2AR_HUMANHPRD12837758 details
ACTN1_HUMANSRC_HUMANHPRD, IntAct16291744 details
ACTN1_HUMANCTNA1_HUMANBioGRID, HPRD, IntAct25241761 7790378 details
ACTN1_HUMANNHRF2_HUMANBioGRID, IntAct27173435 unassigned1312 details
ACTN1_HUMANACTB_HUMANMINT26879394 details
ACTN1_HUMANSTXB1_HUMANIntAct31413325 details
ACTN1_HUMANFMR1_HUMANIntAct31413325 details
ACTN1_HUMANCAC1C_HUMANMINT21653829 details
ACTN1_HUMANARX_HUMANMINT21653829 details
ACTN1_HUMANSHAN3_HUMANMINT21653829 details
ACTN1_HUMANFXR1_HUMANMINT21653829 details
ACTN1_HUMANTSC1_HUMANMINT21653829 details
ACTN1_HUMANPHB_HUMANBioGRID12628297 details
ACTN1_HUMANCEBPA_HUMANBioGRID17082780 details
ACTN1_HUMANTERF1_HUMANBioGRID20811636 details
ACTN1_HUMANTERF2_HUMANBioGRID20811636 details
ACTN1_HUMANZO1_HUMANBioGRID16944923 details
ACTN1_HUMANGLUT4_HUMANBioGRID, HPRD16396496 details
ACTN1_HUMANHS90A_HUMANBioGRID16263121 details
ACTN1_HUMANSVIL_HUMANBioGRID, HPRD12202484 details
ACTN1_HUMANIGSF8_HUMANBioGRID23463506 details
ACTN1_HUMANCD81_HUMANBioGRID23463506 details
ACTN1_HUMANICAM1_HUMANBioGRID23463506 details
ACTN1_HUMANSIR6_HUMANBioGRID24169447 details
ACTN1_HUMANVASP_HUMANBioGRID16376568 details
ACTN1_HUMANTES_HUMANBioGRID, HPRD12695497 28378594 details
ACTN1_HUMANCADH1_HUMANBioGRID9535896 details
ACTN1_HUMANLDB3_HUMANBioGRID24647531 details
ACTN1_HUMANCDK9_HUMANBioGRID26209609 details
ACTN1_HUMANHD_HUMANBioGRID30768638 details
ACTN1_HUMANVINC_HUMANHPRD15988023 details
ACTN1_HUMANCDK5_HUMANHPRD12223541 details
ACTN1_HUMANNMDE1_HUMANHPRD11854440 details
ACTN1_HUMANF16P1_HUMANHPRD12507293 details
ACTN1_HUMANPKD1_HUMANHPRD11113628 details
ACTN1_HUMANPLD2_HUMANHPRD10801846 details
ACTN1_HUMANPDLI5_HUMANHPRD10833443 details
ACTN1_HUMANCLIC5_HUMANHPRD10793131 details
ACTN1_HUMANCSRP3_HUMANHPRD12642359 details
ACTN1_HUMANNEBL_HUMANHPRD10470015 details
ACTN1_HUMANRAVR1_HUMANHPRD11724819 details
ACTN1_HUMANMYOZ3_HUMANHPRD11842093 details
ACTN1_HUMANPTN6_HUMANHPRD15070900 details