Entity Details

Primary name ITA4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13612
EntryNameITA4_HUMAN
FullNameIntegrin alpha-4
TaxID9606
Evidenceevidence at protein level
Length1032
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesITGA4

GO terms

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GOName
GO:0001968 fibronectin binding
GO:0003366 cell-matrix adhesion involved in ameboidal cell migration
GO:0005178 integrin binding
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0009986 cell surface
GO:0015026 coreceptor activity
GO:0016020 membrane
GO:0030183 B cell differentiation
GO:0030198 extracellular matrix organization
GO:0030426 growth cone
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034668 integrin alpha4-beta1 complex
GO:0034669 integrin alpha4-beta7 complex
GO:0035987 endodermal cell differentiation
GO:0043025 neuronal cell body
GO:0043113 receptor clustering
GO:0046872 metal ion binding
GO:0050776 regulation of immune response
GO:0050839 cell adhesion molecule binding
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0050904 diapedesis
GO:0060385 axonogenesis involved in innervation
GO:0070062 extracellular exosome
GO:0071345 cellular response to cytokine stimulus
GO:0090074 negative regulation of protein homodimerization activity
GO:0098657 import into cell
GO:0140039 cell-cell adhesion in response to extracellular stimulus
GO:1903238 positive regulation of leukocyte tethering or rolling
GO:1904646 cellular response to amyloid-beta
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:1990138 neuron projection extension
GO:1990405 protein antigen binding
GO:1990771 clathrin-dependent extracellular exosome endocytosis
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000406 positive regulation of T cell migration

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00108 NatalizumabDrugbankbiotech
DB04997 ATL1102Drugbanksmall molecule
DB05092 CDP323Drugbanksmall molecule
DB05122 R1295Drugbanksmall molecule
DB05468 R411Drugbanksmall molecule
DB06822 TinzaparinDrugbanksmall molecule
DB09033 VedolizumabDrugbankbiotech
DB15791 MK-0668Drugbanksmall molecule

Interactions

281 interactions

InteractorPartnerSourcesPublicationsLink
ITA4_HUMANITA4_HUMANBioGRID, HPRD, IntAct14681217 22623428 9541595 details
ITA4_HUMANITB1_HUMANIntAct, mbinfo10604475 14681217 1542691 20159608 details
ITA4_HUMANITB7_HUMANHPRD, IntAct12682249 14681217 1542691 22232704 details
ITA4_HUMANPAXI_HUMANBioGRID, DIP, HPRD, mbinfo10604475 11533025 11919182 12234367 21173240 details
ITA4_HUMANLEG8_HUMANBioGRID, HPRD, IntAct10852818 26186194 28514442 details
ITA4_HUMANABI1_HUMANDIP21173240 details
ITA4_HUMANEED_HUMANBioGRID, HPRD9765275 details
ITA4_HUMANLYN_HUMANIntAct20159608 details
ITA4_HUMANTGFI1_HUMANHPRD, mbinfo10604475 details
ITA4_HUMANLPXN_HUMANHPRD, mbinfo10604475 details
ITA4_HUMANFLNA_HUMANBioGRID, mbinfo10604475 22623428 details
ITA4_HUMANFINC_HUMANBioGRID, HPRD, IntAct11010812 19738201 24789099 9117345 details
ITA4_HUMANMADCA_HUMANHPRD, IntAct10702270 22232704 9873398 details
ITA4_HUMANCD44_HUMANDIP21257905 details
ITA4_HUMANCD81_HUMANBioGRID, HPRD10229664 details
ITA4_HUMANFAK1_HUMANBioGRID11919182 details
ITA4_HUMANCLH1_HUMANBioGRID22623428 details
ITA4_HUMANPRKDC_HUMANBioGRID22623428 details
ITA4_HUMANHNRPM_HUMANBioGRID22623428 details
ITA4_HUMANHSP7C_HUMANBioGRID22623428 details
ITA4_HUMANTBB4B_HUMANBioGRID22623428 details
ITA4_HUMANDDX5_HUMANBioGRID22623428 details
ITA4_HUMANACTB_HUMANBioGRID22623428 details
ITA4_HUMANACTG_HUMANBioGRID22623428 details
ITA4_HUMANHS90B_HUMANBioGRID22623428 details
ITA4_HUMANFUBP2_HUMANBioGRID22623428 details
ITA4_HUMANTLN1_HUMANBioGRID22623428 details
ITA4_HUMANPDC6I_HUMANBioGRID22623428 details
ITA4_HUMANCLIC1_HUMANBioGRID22623428 details
ITA4_HUMANROA2_HUMANBioGRID22623428 details
ITA4_HUMANVIME_HUMANBioGRID22623428 details
ITA4_HUMANCH60_HUMANBioGRID22623428 details
ITA4_HUMANRS3_HUMANBioGRID22623428 details
ITA4_HUMANBUB3_HUMANBioGRID22623428 details
ITA4_HUMANPRDX1_HUMANBioGRID22623428 details
ITA4_HUMANAP2A1_HUMANBioGRID22623428 details
ITA4_HUMANSYVC_HUMANBioGRID22623428 details
ITA4_HUMANEF2_HUMANBioGRID22623428 details
ITA4_HUMANPABP1_HUMANBioGRID22623428 details
ITA4_HUMANTBA1C_HUMANBioGRID22623428 details
ITA4_HUMANK1C16_HUMANBioGRID22623428 details
ITA4_HUMANFUBP3_HUMANBioGRID22623428 details
ITA4_HUMANEF1A1_HUMANBioGRID22623428 details
ITA4_HUMANHBG1_HUMANBioGRID22623428 details
ITA4_HUMANHNRH3_HUMANBioGRID22623428 details
ITA4_HUMANK2C1_HUMANBioGRID22623428 details
ITA4_HUMANUBP2L_HUMANBioGRID22623428 details
ITA4_HUMANCDK1_HUMANBioGRID22623428 details
ITA4_HUMANRS18_HUMANBioGRID22623428 details
ITA4_HUMANPICAL_HUMANBioGRID22623428 details
ITA4_HUMANHSPB1_HUMANBioGRID22623428 details
ITA4_HUMANNSUN2_HUMANBioGRID22623428 details
ITA4_HUMANG3P_HUMANBioGRID22623428 details
ITA4_HUMANHNRPK_HUMANBioGRID22623428 details
ITA4_HUMANH4_HUMANBioGRID22623428 details
ITA4_HUMANIF4G1_HUMANBioGRID22623428 details
ITA4_HUMANPTBP1_HUMANBioGRID22623428 details
ITA4_HUMANHNRPL_HUMANBioGRID22623428 details
ITA4_HUMANRS4X_HUMANBioGRID22623428 details
ITA4_HUMANRS14_HUMANBioGRID22623428 details
ITA4_HUMANTAGL2_HUMANBioGRID22623428 details
ITA4_HUMANIF2B1_HUMANBioGRID22623428 details
ITA4_HUMANDDX3X_HUMANBioGRID22623428 details
ITA4_HUMANK2C6A_HUMANBioGRID22623428 details
ITA4_HUMANCAN1_HUMANBioGRID22623428 details
ITA4_HUMANRBM4_HUMANBioGRID22623428 details
ITA4_HUMANRAN_HUMANBioGRID22623428 details
ITA4_HUMANPRP8_HUMANBioGRID22623428 details
ITA4_HUMANIF4G2_HUMANBioGRID22623428 details
ITA4_HUMANPARP1_HUMANBioGRID22623428 details
ITA4_HUMANNTPCR_HUMANBioGRID22623428 details
ITA4_HUMANRS27A_HUMANBioGRID22623428 details
ITA4_HUMANRL40_HUMANBioGRID22623428 details
ITA4_HUMANUBB_HUMANBioGRID22623428 details
ITA4_HUMANUBC_HUMANBioGRID22623428 details
ITA4_HUMANH2B1L_HUMANBioGRID22623428 details
ITA4_HUMANH2B1C_HUMANBioGRID22623428 details
ITA4_HUMANH2B1D_HUMANBioGRID22623428 details
ITA4_HUMANH2B1H_HUMANBioGRID22623428 details
ITA4_HUMANH2B2F_HUMANBioGRID22623428 details
ITA4_HUMANH2B1M_HUMANBioGRID22623428 details
ITA4_HUMANH2B1N_HUMANBioGRID22623428 details
ITA4_HUMANH13_HUMANBioGRID22623428 details
ITA4_HUMANSHIP2_HUMANBioGRID22623428 details
ITA4_HUMANTCRG1_HUMANBioGRID22623428 details
ITA4_HUMANPIMT_HUMANBioGRID22623428 details
ITA4_HUMANPCBP1_HUMANBioGRID22623428 details
ITA4_HUMANGCN1_HUMANBioGRID22623428 details
ITA4_HUMANGRB2_HUMANBioGRID22623428 details
ITA4_HUMANHNRPU_HUMANBioGRID22623428 details
ITA4_HUMANSMD2_HUMANBioGRID22623428 details
ITA4_HUMANCPSF5_HUMANBioGRID22623428 details
ITA4_HUMANU520_HUMANBioGRID22623428 details
ITA4_HUMANRS19_HUMANBioGRID22623428 details
ITA4_HUMANNU214_HUMANBioGRID22623428 details
ITA4_HUMANANXA1_HUMANBioGRID22623428 details
ITA4_HUMANRBM14_HUMANBioGRID22623428 details
ITA4_HUMAN1433Z_HUMANBioGRID22623428 details
ITA4_HUMANPTN23_HUMANBioGRID22623428 details
ITA4_HUMANHBA_HUMANBioGRID22623428 details
ITA4_HUMANPPIA_HUMANBioGRID22623428 details
ITA4_HUMANHNRH1_HUMANBioGRID22623428 details
ITA4_HUMANHBE_HUMANBioGRID22623428 details
ITA4_HUMANROA1_HUMANBioGRID22623428 details
ITA4_HUMANH32_HUMANBioGRID22623428 details
ITA4_HUMANH33_HUMANBioGRID22623428 details
ITA4_HUMANH31_HUMANBioGRID22623428 details
ITA4_HUMANH31T_HUMANBioGRID22623428 details
ITA4_HUMANRS3A_HUMANBioGRID22623428 details
ITA4_HUMANHNRPC_HUMANBioGRID22623428 details
ITA4_HUMANIST1_HUMANBioGRID22623428 details
ITA4_HUMANSYEP_HUMANBioGRID22623428 details
ITA4_HUMANDDX21_HUMANBioGRID22623428 details
ITA4_HUMANHNRPD_HUMANBioGRID22623428 details
ITA4_HUMANSDCB1_HUMANBioGRID22623428 details
ITA4_HUMANPROF1_HUMANBioGRID22623428 details
ITA4_HUMANIF2B2_HUMANBioGRID22623428 details
ITA4_HUMANARK72_HUMANBioGRID22623428 details
ITA4_HUMANSFPQ_HUMANBioGRID22623428 details
ITA4_HUMANAP2B1_HUMANBioGRID22623428 details
ITA4_HUMANCLCA_HUMANBioGRID22623428 details
ITA4_HUMANPHB2_HUMANBioGRID22623428 details
ITA4_HUMANDYN2_HUMANBioGRID22623428 details
ITA4_HUMANPYR1_HUMANBioGRID22623428 details
ITA4_HUMANNQO1_HUMANBioGRID22623428 details
ITA4_HUMANACTN4_HUMANBioGRID22623428 details
ITA4_HUMANMCM5_HUMANBioGRID22623428 details
ITA4_HUMANRS9_HUMANBioGRID22623428 details
ITA4_HUMANDYHC1_HUMANBioGRID22623428 details
ITA4_HUMANRL11_HUMANBioGRID22623428 details
ITA4_HUMANCHM4B_HUMANBioGRID22623428 details
ITA4_HUMANSYLC_HUMANBioGRID22623428 details
ITA4_HUMANRSSA_HUMANBioGRID22623428 details
ITA4_HUMANLMNA_HUMANBioGRID22623428 details
ITA4_HUMANH2A1B_HUMANBioGRID22623428 details
ITA4_HUMANH2A1_HUMANBioGRID22623428 details
ITA4_HUMANH2A3_HUMANBioGRID22623428 details
ITA4_HUMANH2A1C_HUMANBioGRID22623428 details
ITA4_HUMANRAC2_HUMANBioGRID22623428 details
ITA4_HUMANK1C19_HUMANBioGRID22623428 details
ITA4_HUMANLPPRC_HUMANBioGRID22623428 details
ITA4_HUMANRL22_HUMANBioGRID22623428 details
ITA4_HUMANPPIL1_HUMANBioGRID22623428 details
ITA4_HUMANRL23_HUMANBioGRID22623428 details
ITA4_HUMANCH10_HUMANBioGRID22623428 details
ITA4_HUMANRL30_HUMANBioGRID22623428 details
ITA4_HUMANRS5_HUMANBioGRID22623428 details
ITA4_HUMANAPT_HUMANBioGRID22623428 details
ITA4_HUMANRL18_HUMANBioGRID22623428 details
ITA4_HUMANHNRPQ_HUMANBioGRID22623428 details
ITA4_HUMANTCPH_HUMANBioGRID22623428 details
ITA4_HUMANEF1D_HUMANBioGRID22623428 details
ITA4_HUMANRS11_HUMANBioGRID22623428 details
ITA4_HUMANURP2_HUMANBioGRID22623428 details
ITA4_HUMANRS21_HUMANBioGRID22623428 details
ITA4_HUMANPRDX2_HUMANBioGRID22623428 details
ITA4_HUMANHNRPR_HUMANBioGRID22623428 details
ITA4_HUMANTCPZ_HUMANBioGRID22623428 details
ITA4_HUMANATX2L_HUMANBioGRID22623428 details
ITA4_HUMANPRDX6_HUMANBioGRID22623428 details
ITA4_HUMANRS8_HUMANBioGRID22623428 details
ITA4_HUMANK2C8_HUMANBioGRID22623428 details
ITA4_HUMANRS13_HUMANBioGRID22623428 details
ITA4_HUMANXPO5_HUMANBioGRID22623428 details
ITA4_HUMANSF01_HUMANBioGRID22623428 details
ITA4_HUMANEWS_HUMANBioGRID22623428 details
ITA4_HUMANCSK2B_HUMANBioGRID22623428 details
ITA4_HUMANNUCL_HUMANBioGRID22623428 details
ITA4_HUMANTCPD_HUMANBioGRID22623428 details
ITA4_HUMANFUBP1_HUMANBioGRID22623428 details
ITA4_HUMANCHM2A_HUMANBioGRID22623428 details
ITA4_HUMANROA0_HUMANBioGRID22623428 details
ITA4_HUMANRL12_HUMANBioGRID22623428 details
ITA4_HUMANCPNS1_HUMANBioGRID22623428 details
ITA4_HUMANSRP09_HUMANBioGRID22623428 details
ITA4_HUMANRS20_HUMANBioGRID22623428 details
ITA4_HUMANRS16_HUMANBioGRID22623428 details
ITA4_HUMANCBL_HUMANBioGRID22623428 details
ITA4_HUMANSNX3_HUMANBioGRID22623428 details
ITA4_HUMANRENT1_HUMANBioGRID22623428 details
ITA4_HUMANRS6_HUMANBioGRID22623428 details
ITA4_HUMANHBAZ_HUMANBioGRID22623428 details
ITA4_HUMANK1C9_HUMANBioGRID22623428 details
ITA4_HUMANPCBP2_HUMANBioGRID22623428 details
ITA4_HUMANLYPA1_HUMANBioGRID22623428 details
ITA4_HUMANHS71A_HUMANBioGRID22623428 details
ITA4_HUMANHS71B_HUMANBioGRID22623428 details
ITA4_HUMANTCPQ_HUMANBioGRID22623428 details
ITA4_HUMANHIP1R_HUMANBioGRID22623428 details
ITA4_HUMANRL13_HUMANBioGRID22623428 details
ITA4_HUMANPDCD6_HUMANBioGRID22623428 details
ITA4_HUMANFUS_HUMANBioGRID22623428 details
ITA4_HUMANROAA_HUMANBioGRID22623428 details
ITA4_HUMANRLA0_HUMANBioGRID22623428 details
ITA4_HUMANESYT1_HUMANBioGRID22623428 details
ITA4_HUMANRL9_HUMANBioGRID22623428 details
ITA4_HUMANADT2_HUMANBioGRID22623428 details
ITA4_HUMANXRCC6_HUMANBioGRID22623428 details
ITA4_HUMANLRC59_HUMANBioGRID22623428 details
ITA4_HUMANTIAR_HUMANBioGRID22623428 details
ITA4_HUMANSYIC_HUMANBioGRID22623428 details
ITA4_HUMANKSYK_HUMANBioGRID22623428 details
ITA4_HUMANSYMC_HUMANBioGRID22623428 details
ITA4_HUMANRL38_HUMANBioGRID22623428 details
ITA4_HUMAN1433E_HUMANBioGRID22623428 details
ITA4_HUMANILF2_HUMANBioGRID22623428 details
ITA4_HUMANHBG2_HUMANBioGRID22623428 details
ITA4_HUMANMBNL1_HUMANBioGRID22623428 details
ITA4_HUMANTOP2A_HUMANBioGRID22623428 details
ITA4_HUMANTADBP_HUMANBioGRID22623428 details
ITA4_HUMANRS15A_HUMANBioGRID22623428 details
ITA4_HUMANMIF_HUMANBioGRID22623428 details
ITA4_HUMANTOM34_HUMANBioGRID22623428 details
ITA4_HUMANTTC9C_HUMANBioGRID22623428 details
ITA4_HUMANDAZP1_HUMANBioGRID22623428 details
ITA4_HUMANRS28_HUMANBioGRID22623428 details
ITA4_HUMANCOF1_HUMANBioGRID22623428 details
ITA4_HUMANMCM7_HUMANBioGRID22623428 details
ITA4_HUMANPPIH_HUMANBioGRID22623428 details
ITA4_HUMANACTC_HUMANBioGRID22623428 details
ITA4_HUMANPSB1_HUMANBioGRID22623428 details
ITA4_HUMANTERA_HUMANBioGRID22623428 details
ITA4_HUMANATP5I_HUMANBioGRID22623428 details
ITA4_HUMANPIN1_HUMANBioGRID22623428 details
ITA4_HUMANSRSF9_HUMANBioGRID22623428 details
ITA4_HUMANPUM1_HUMANBioGRID22623428 details
ITA4_HUMANRAB10_HUMANBioGRID22623428 details
ITA4_HUMANRL23A_HUMANBioGRID22623428 details
ITA4_HUMANRL26_HUMANBioGRID22623428 details
ITA4_HUMANTCPB_HUMANBioGRID22623428 details
ITA4_HUMANRL35_HUMANBioGRID22623428 details
ITA4_HUMANSTMN1_HUMANBioGRID22623428 details
ITA4_HUMANYBOX1_HUMANBioGRID22623428 details
ITA4_HUMANCPSF7_HUMANBioGRID22623428 details
ITA4_HUMANPSA7_HUMANBioGRID22623428 details
ITA4_HUMANLSM3_HUMANBioGRID22623428 details
ITA4_HUMANHCD2_HUMANBioGRID22623428 details
ITA4_HUMANSTOM_HUMANBioGRID22623428 details
ITA4_HUMANRS25_HUMANBioGRID22623428 details
ITA4_HUMANPSME3_HUMANBioGRID22623428 details
ITA4_HUMANXPO2_HUMANBioGRID22623428 details
ITA4_HUMANDNJC7_HUMANBioGRID22623428 details
ITA4_HUMANSMD1_HUMANBioGRID22623428 details
ITA4_HUMANIF2A_HUMANBioGRID22623428 details
ITA4_HUMANRUXF_HUMANBioGRID22623428 details
ITA4_HUMANNDUA2_HUMANBioGRID22623428 details
ITA4_HUMANRL14_HUMANBioGRID22623428 details
ITA4_HUMANSDHB_HUMANBioGRID22623428 details
ITA4_HUMANRL17_HUMANBioGRID22623428 details
ITA4_HUMANU5S1_HUMANBioGRID22623428 details
ITA4_HUMANDDX1_HUMANBioGRID22623428 details
ITA4_HUMANSND1_HUMANBioGRID22623428 details
ITA4_HUMANDDX17_HUMANBioGRID22623428 details
ITA4_HUMANPHB_HUMANBioGRID22623428 details
ITA4_HUMANHEAT1_HUMANBioGRID22623428 details
ITA4_HUMANIF4E_HUMANBioGRID22623428 details
ITA4_HUMANFCG2C_HUMANBioGRID22623428 details
ITA4_HUMANFCG2A_HUMANBioGRID22623428 details
ITA4_HUMANRL1D1_HUMANBioGRID22623428 details
ITA4_HUMANLDHA_HUMANBioGRID22623428 details
ITA4_HUMANPABP4_HUMANBioGRID22623428 details
ITA4_HUMANDECR_HUMANBioGRID22623428 details
ITA4_HUMANPFKAP_HUMANBioGRID22623428 details
ITA4_HUMANANR17_HUMANBioGRID22623428 details
ITA4_HUMANDRG1_HUMANBioGRID22623428 details
ITA4_HUMANRS2_HUMANBioGRID22623428 details
ITA4_HUMANXRCC5_HUMANBioGRID22623428 details
ITA4_HUMANTCPA_HUMANBioGRID22623428 details
ITA4_HUMANSC24C_HUMANBioGRID22623428 details
ITA4_HUMANEIF3K_HUMANBioGRID22623428 details
ITA4_HUMANPPAC_HUMANBioGRID22623428 details
ITA4_HUMANCCAR2_HUMANBioGRID22623428 details
ITA4_HUMANITAV_HUMANBioGRID25792870 details
ITA4_HUMANITB3_HUMANBioGRID25792870 details
ITA4_HUMANRASH_HUMANBioGRID28177903 details
ITA4_HUMANKAPCA_HUMANHPRD11533025 details
ITA4_HUMANADA28_HUMANHPRD11724793 details
ITA4_HUMANICAM4_HUMANHPRD11435317 details
ITA4_HUMANCD82_HUMANHPRD8757325 details
ITA4_HUMANCSPG2_HUMANHPRD11083865 details
ITA4_HUMANKAP0_HUMANHPRD17369818 details