Entity Details

Primary name 3BHS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14060
EntryName3BHS1_HUMAN
FullName3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
TaxID9606
Evidenceevidence at protein level
Length373
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesHSD3B1

GO terms

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GOName
GO:0000253 3-keto sterol reductase activity
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004769 steroid delta-isomerase activity
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006694 steroid biosynthetic process
GO:0006702 androgen biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0006705 mineralocorticoid biosynthetic process
GO:0008207 C21-steroid hormone metabolic process
GO:0016021 integral component of membrane
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0021766 hippocampus development
GO:0030868 smooth endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045171 intercellular bridge
GO:0047024 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO:0051412 response to corticosterone
GO:0102294 cholesterol dehydrogenase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Mitochondrion membrane

Domains

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DomainNameCategoryType
IPR002225 3-beta hydroxysteroid dehydrogenase/isomeraseDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB01108 TrilostaneDrugbanksmall molecule
DB01536 AndrostenedioneDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB09070 TiboloneDrugbanksmall molecule
DB14538 Hydrocortisone aceponateDrugbanksmall molecule
DB14539 Hydrocortisone acetateDrugbanksmall molecule
DB14540 Hydrocortisone butyrateDrugbanksmall molecule
DB14541 Hydrocortisone cypionateDrugbanksmall molecule
DB14542 Hydrocortisone phosphateDrugbanksmall molecule
DB14543 Hydrocortisone probutateDrugbanksmall molecule
DB14544 Hydrocortisone valerateDrugbanksmall molecule