Entity Details

Primary name RAG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15918
EntryNameRAG1_HUMAN
FullNameV(D)J recombination-activating protein 1
TaxID9606
Evidenceevidence at protein level
Length1043
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesRAG1

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002331 pre-B cell allelic exclusion
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006310 DNA recombination
GO:0006955 immune response
GO:0008270 zinc ion binding
GO:0008542 visual learning
GO:0010390 histone monoubiquitination
GO:0030183 B cell differentiation
GO:0033077 T cell differentiation in thymus
GO:0033151 V(D)J recombination
GO:0042393 histone binding
GO:0042803 protein homodimerization activity
GO:0043029 T cell homeostasis
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045582 positive regulation of T cell differentiation
GO:0046872 metal ion binding
GO:0048538 thymus development
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0097519 DNA recombinase complex
GO:1905347 endodeoxyribonuclease complex
GO:2000822 regulation of behavioral fear response

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR019485 V(D)J recombination-activating protein 1, Zinc fingerDomainDomain
IPR023336 RAG nonamer-binding domainDomainDomain
IPR024627 V(D)J recombination-activating protein 1FamilyFamily
IPR035714 RAG1 importin-bindingDomainDomain
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
RAG1_HUMANIMA5_HUMANBioGRID, HPRD, MINT8052633 8777717 details
RAG1_HUMANCRK_HUMANIntAct17474147 details
RAG1_HUMANNCK1_HUMANIntAct17474147 details
RAG1_HUMANPLCG1_HUMANIntAct17474147 details
RAG1_HUMANRAG2_HUMANBioGRID, HPRD12861017 14670978 25745109 26124138 8777717 9036966 9630231 details
RAG1_HUMANHMGB1_HUMANBioGRID, HPRD10490593 details
RAG1_HUMANHMGB2_HUMANBioGRID, HPRD10490593 details
RAG1_HUMANIMA1_HUMANBioGRID, HPRD8016130 8777717 details
RAG1_HUMANH31T_HUMANBioGRID20122409 details
RAG1_HUMANH4_HUMANBioGRID20122409 details
RAG1_HUMANH2A2C_HUMANBioGRID20122409 details
RAG1_HUMANH2B2E_HUMANBioGRID20122409 details
RAG1_HUMANH31_HUMANBioGRID21256161 details
RAG1_HUMANDCAF1_HUMANBioGRID22157821 details
RAG1_HUMANUB2D2_HUMANBioGRID12629039 20122409 26124138 details
RAG1_HUMANUBE2H_HUMANBioGRID21256161 details
RAG1_HUMANA4_HUMANBioGRID21244100 details
RAG1_HUMANUBE2C_HUMANBioGRID12629039 details
RAG1_HUMANUBC_HUMANBioGRID12629039 details
RAG1_HUMANRAG1_HUMANBioGRID26124138 details
RAG1_HUMANUB2D1_HUMANBioGRID26124138 details
RAG1_HUMANHS90B_HUMANIntAct22939624 details
RAG1_HUMANFKBP5_HUMANIntAct25036637 details
RAG1_HUMANNUDC_HUMANIntAct25036637 details
RAG1_HUMANNUDC3_HUMANIntAct25036637 details
RAG1_HUMANCYBP_HUMANIntAct25036637 details
RAG1_HUMANTEBP_HUMANIntAct25036637 details
RAG1_HUMANDDB1_HUMANBioGRID22157821 details
RAG1_HUMANRBX1_HUMANBioGRID22157821 details
RAG1_HUMANCUL4A_HUMANBioGRID22157821 details
RAG1_HUMANHS90A_HUMANBioGRID22939624 details
RAG1_HUMANMDC1_HUMANBioGRID22942284 details
RAG1_HUMANRUNX1_HUMANBioGRID25135298 details