Entity Details

Primary name TIMP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16035
EntryNameTIMP2_HUMAN
FullNameMetalloproteinase inhibitor 2
TaxID9606
Evidenceevidence at protein level
Length220
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesTIMP2

GO terms

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GOName
GO:0002020 protease binding
GO:0004857 enzyme inhibitor activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007417 central nervous system development
GO:0007568 aging
GO:0008191 metalloendopeptidase inhibitor activity
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009725 response to hormone
GO:0009986 cell surface
GO:0010033 response to organic substance
GO:0010951 negative regulation of endopeptidase activity
GO:0022617 extracellular matrix disassembly
GO:0030414 peptidase inhibitor activity
GO:0030426 growth cone
GO:0031012 extracellular matrix
GO:0032487 regulation of Rap protein signal transduction
GO:0034097 response to cytokine
GO:0035580 specific granule lumen
GO:0042493 response to drug
GO:0043025 neuronal cell body
GO:0043312 neutrophil degranulation
GO:0043410 positive regulation of MAPK cascade
GO:0045666 positive regulation of neuron differentiation
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045930 negative regulation of mitotic cell cycle
GO:0046580 negative regulation of Ras protein signal transduction
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0062023 collagen-containing extracellular matrix
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen
GO:1905049 negative regulation of metallopeptidase activity

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001134 Netrin domainDomainDomain
IPR001820 Protease inhibitor I35 (TIMP)FamilyFamily
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR015613 Metalloproteinase inhibitor 2FamilyFamily
IPR027465 Proteinase inhibitor I35b (TIMP), C-terminalFamilyHomologous superfamily
IPR030490 Tissue inhibitor of metalloproteinase, conserved siteSiteConserved site

Diseases

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