Entity Details

Primary name CREB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16220
EntryNameCREB1_HUMAN
FullNameCyclic AMP-responsive element-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length327
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesCREB1

GO terms

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GOName
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005759 mitochondrial matrix
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007409 axonogenesis
GO:0007568 aging
GO:0007595 lactation
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0008361 regulation of cell size
GO:0008542 visual learning
GO:0010033 response to organic substance
GO:0010629 negative regulation of gene expression
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0014823 response to activity
GO:0016032 viral process
GO:0019899 enzyme binding
GO:0021983 pituitary gland development
GO:0030424 axon
GO:0030544 Hsp70 protein binding
GO:0032916 positive regulation of transforming growth factor beta3 production
GO:0033363 secretory granule organization
GO:0033762 response to glucagon
GO:0034670 chemotaxis to arachidonic acid
GO:0035035 histone acetyltransferase binding
GO:0035094 response to nicotine
GO:0035497 cAMP response element binding
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0040018 positive regulation of multicellular organism growth
GO:0042493 response to drug
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046887 positive regulation of hormone secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048145 regulation of fibroblast proliferation
GO:0050821 protein stabilization
GO:0055025 positive regulation of cardiac muscle tissue development
GO:0060251 regulation of glial cell proliferation
GO:0060430 lung saccule development
GO:0060509 type I pneumocyte differentiation
GO:0071294 cellular response to zinc ion
GO:0071300 cellular response to retinoic acid
GO:0071398 cellular response to fatty acid
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901215 negative regulation of neuron death
GO:1902065 response to L-glutamate
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990589 ATF4-CREB1 transcription factor complex
GO:1990763 arrestin family protein binding
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001630 cAMP response element binding (CREB) proteinFamilyFamily
IPR003102 Coactivator CBP, pKIDDomainDomain
IPR004827 Basic-leucine zipper domainDomainDomain
IPR029802 cAMP-responsive element-binding protein 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB01183 NaloxoneDrugbanksmall molecule

Interactions

118 interactions

InteractorPartnerSourcesPublicationsLink
CREB1_HUMANBRCA1_HUMANMINT9926942 details
CREB1_HUMANSGK1_HUMANHPRD, MINT15733869 details
CREB1_HUMANCHD3_HUMANBioGRID, HPRD, IntAct16169070 details
CREB1_HUMANVIME_HUMANBioGRID, HPRD, IntAct16169070 details
CREB1_HUMANERG28_HUMANBioGRID, HPRD, IntAct16169070 details
CREB1_HUMANRECQ5_HUMANBioGRID, HPRD, IntAct16169070 details
CREB1_HUMANRAB1A_HUMANBioGRID, HPRD, IntAct16169070 details
CREB1_HUMANHPS6_HUMANHPRD, IntAct16169070 details
CREB1_HUMANKS6A1_HUMANBioGRID, HPRD, IntAct11175347 12235136 16282323 21832046 8688081 9687510 9829964 details
CREB1_HUMANATR_HUMANBioGRID, IntAct16293623 details
CREB1_HUMANTSSK4_HUMANBioGRID, HPRD, IntAct15964553 21988832 details
CREB1_HUMANEP300_HUMANBioGRID, MINT10506141 11313407 12665587 17476304 21212407 21268077 22787115 26944191 7870179 details
CREB1_HUMANCBP_HUMANBioGRID, DIP, HPRD, IntAct, MINT10848610 10866654 11259575 11313407 11564156 12196545 12198160 12933667 15073328 15585582 15691881 16799563 17476304 17707401 18599546 20403362 20541704 23671189 27789289 7870179 8028671 8413673 8663317 9413984 9786917 9829964 details
CREB1_HUMANATF6A_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANTOX4_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANCHD8_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANHIPK3_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANTF2AA_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANCRTC1_HUMANBioGRID, IntAct20936779 32296183 details
CREB1_HUMANPOGZ_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANRN111_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANSRBP2_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANPIAS1_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANZMYM2_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANZHX1_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANUBC9_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANK2026_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANZN451_HUMANBioGRID, IntAct20936779 details
CREB1_HUMANPASK_HUMANMINT21418524 details
CREB1_HUMANP53_HUMANBioGRID, IntAct10848610 16611888 21295542 25241761 details
CREB1_HUMANATF1_HUMANBioGRID, HPIDb, HPRD, MINT1655749 20102225 25609649 8384217 details
CREB1_HUMANNFIL3_HUMANBioGRID, HPIDb, IntAct, MINT20102225 25609649 28514442 details
CREB1_HUMANCREB1_HUMANBioGRID, HPIDb, MINT, UniProt20102225 23661758 25609649 details
CREB1_HUMANBACH1_HUMANHPIDb20102225 details
CREB1_HUMANCR3L3_HUMANHPIDb20102225 details
CREB1_HUMANSMCO1_HUMANBioGRID, IntAct27107012 details
CREB1_HUMANPIAS2_HUMANBioGRID, IntAct32296183 details
CREB1_HUMANAGR2_HUMANBioGRID, IntAct32296183 details
CREB1_HUMANCRTC2_HUMANBioGRID, IntAct32296183 details
CREB1_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
CREB1_HUMANHD_HUMANBioGRID, IntAct16207717 32814053 details
CREB1_HUMANTRI22_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANZNF92_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANMTF2_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANSUZ12_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANRFX3_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANZNF35_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANZN436_HUMANBioGRID, IntAct20211142 details
CREB1_HUMANABL1_HUMANBioGRID, HPRD7565761 details
CREB1_HUMANCEBPB_HUMANBioGRID, HPRD12773552 details
CREB1_HUMANKAT5_HUMANBioGRID, HPRD10720489 details
CREB1_HUMANKCC2A_HUMANBioGRID8663317 details
CREB1_HUMANRBBP4_HUMANBioGRID10866654 details
CREB1_HUMANKS6A5_HUMANBioGRID, HPRD11018520 11500364 11909979 16223362 9687510 9873047 details
CREB1_HUMANKS6A4_HUMANBioGRID, HPRD11175347 8688081 9687510 9792677 9829964 details
CREB1_HUMANGLI2_HUMANBioGRID, HPRD10074179 details
CREB1_HUMANFHL5_HUMANBioGRID, HPRD11046156 details
CREB1_HUMANFHL2_HUMANBioGRID11046156 details
CREB1_HUMANFHL3_HUMANBioGRID11046156 details
CREB1_HUMANKAPCA_HUMANBioGRID11500364 12805224 details
CREB1_HUMANHNF1B_HUMANBioGRID9671480 details
CREB1_HUMANGCR_HUMANBioGRID, HPRD20203101 7621901 8449898 details
CREB1_HUMANMCAF1_HUMANBioGRID20936779 details
CREB1_HUMANHDAC1_HUMANBioGRID12567184 20473547 details
CREB1_HUMANPO2F1_HUMANBioGRID12391146 details
CREB1_HUMANCCDC6_HUMANBioGRID20498639 details
CREB1_HUMANPP1A_HUMANBioGRID20498639 details
CREB1_HUMANRGS13_HUMANBioGRID20974683 details
CREB1_HUMANTYY1_HUMANBioGRID7769693 details
CREB1_HUMANGSK3B_HUMANBioGRID, HPRD12162494 14635195 details
CREB1_HUMANGSK3A_HUMANBioGRID14635195 details
CREB1_HUMANSRA1_HUMANBioGRID20398657 details
CREB1_HUMANAKT1_HUMANBioGRID, HPRD9829964 details
CREB1_HUMANDAXX_HUMANBioGRID22185778 details
CREB1_HUMANKGP1_HUMANBioGRID, HPRD11175347 8688081 9687510 9829964 details
CREB1_HUMANNR5A2_HUMANBioGRID18191017 details
CREB1_HUMANATM_HUMANBioGRID, HPRD15073328 16293623 details
CREB1_HUMANDNM3L_HUMANBioGRID24952347 details
CREB1_HUMANTHA_HUMANBioGRID, HPRD12805224 details
CREB1_HUMANZEP1_HUMANBioGRID32296183 details
CREB1_HUMANPTEN_HUMANBioGRID31217297 details
CREB1_HUMANMEIS1_HUMANBioGRID, IntAct20159610 20541704 details
CREB1_HUMANNFAC1_HUMANBioGRID, MINT25609649 27637333 details
CREB1_HUMANNFAC2_HUMANBioGRID, MINT25609649 27637333 details
CREB1_HUMANCREM_HUMANBioGRID, HPRD, MINT22531917 25609649 7809053 details
CREB1_HUMANJUN_HUMANBioGRID, MINT2138276 25609649 details
CREB1_HUMANCSEN_HUMANBioGRID, HPRD12198160 details
CREB1_HUMANH31_HUMANBioGRID12933667 19279000 details
CREB1_HUMANHDAC8_HUMANBioGRID19070599 details
CREB1_HUMANDACH1_HUMANBioGRID16980615 details
CREB1_HUMANSMCA4_HUMANBioGRID16675956 23671189 details
CREB1_HUMANSMCA5_HUMANBioGRID, HPRD16675956 details
CREB1_HUMANCARM1_HUMANBioGRID16330542 details
CREB1_HUMANMYOD1_HUMANBioGRID12665587 details
CREB1_HUMANHDAC2_HUMANBioGRID12567184 20473547 details
CREB1_HUMANTAF4_HUMANBioGRID15703171 details
CREB1_HUMANDNM3B_HUMANBioGRID19786833 details
CREB1_HUMANATX3_HUMANBioGRID11572863 details
CREB1_HUMANSIR1_HUMANBioGRID23382074 details
CREB1_HUMANYAP1_HUMANBioGRID23532963 31496812 32220262 details
CREB1_HUMANMK14_HUMANBioGRID, HPRD11377386 23532963 details
CREB1_HUMANDEAF1_HUMANBioGRID23846693 details
CREB1_HUMANNCOR1_HUMANBioGRID24315104 details
CREB1_HUMANCTNB1_HUMANBioGRID17962194 19223551 23671189 details
CREB1_HUMANTRAF3_HUMANBioGRID26755589 details
CREB1_HUMANSTAT3_HUMANBioGRID26508788 details
CREB1_HUMANRFX5_HUMANBioGRID23671189 details
CREB1_HUMANNFYB_HUMANBioGRID23671189 details
CREB1_HUMANHIF1A_HUMANBioGRID27808477 details
CREB1_HUMANDYR1A_HUMANHPRD15694837 details
CREB1_HUMANSRF_HUMANHPRD7551568 9388250 details
CREB1_HUMANT2FB_HUMANHPRD8628277 details
CREB1_HUMANKS6A3_HUMANHPRD11160957 11175347 8688081 9687510 9829964 details
CREB1_HUMANPDX1_HUMANHPRD7505393 details
CREB1_HUMANKS6A2_HUMANHPRD11175347 11698596 8688081 9687510 9829964 details
CREB1_HUMANEDF1_HUMANHPRD10567391 details
CREB1_HUMANMAPK2_HUMANHPRD8887554 details
CREB1_HUMANSOX9_HUMANHPRD19113914 details