Entity Details

Primary name AT2A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16615
EntryNameAT2A2_HUMAN
FullNameSarcoplasmic/endoplasmic reticulum calcium ATPase 2
TaxID9606
Evidenceevidence at protein level
Length1042
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesATP2A2

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0002026 regulation of the force of heart contraction
GO:0003009 skeletal muscle contraction
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006984 ER-nucleus signaling pathway
GO:0007155 cell adhesion
GO:0008022 protein C-terminus binding
GO:0008544 epidermis development
GO:0008553 P-type proton-exporting transporter activity
GO:0010460 positive regulation of heart rate
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0012506 vesicle membrane
GO:0014801 longitudinal sarcoplasmic reticulum
GO:0014883 transition between fast and slow fiber
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016020 membrane
GO:0016240 autophagosome membrane docking
GO:0016529 sarcoplasmic reticulum
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0031095 platelet dense tubular network membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031775 lutropin-choriogonadotropic hormone receptor binding
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0033017 sarcoplasmic reticulum membrane
GO:0033292 T-tubule organization
GO:0034220 ion transmembrane transport
GO:0034599 cellular response to oxidative stress
GO:0034605 cellular response to heat
GO:0034976 response to endoplasmic reticulum stress
GO:0044325 transmembrane transporter binding
GO:0044548 S100 protein binding
GO:0045822 negative regulation of heart contraction
GO:0048471 perinuclear region of cytoplasm
GO:0055119 relaxation of cardiac muscle
GO:0061831 apical ectoplasmic specialization
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:0070588 calcium ion transmembrane transport
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0086039 P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
GO:0090534 calcium ion-transporting ATPase complex
GO:0097470 ribbon synapse
GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:0120025 plasma membrane bounded cell projection
GO:0140056 organelle localization by membrane tethering
GO:1900121 negative regulation of receptor binding
GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter
GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum
GO:1903779 regulation of cardiac conduction
GO:1990036 calcium ion import into sarcoplasmic reticulum
GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Sarcoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR005782 P-type ATPase, subfamily IIA, SERCA-typeFamilyFamily
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01189 DesfluraneDrugbanksmall molecule
DB06157 IstaroximeDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
AT2A2_HUMANPAR2_HUMANBioGRID, MINT28298427 details
AT2A2_HUMANCCR4_HUMANBioGRID, MINT28298427 details
AT2A2_HUMANACM5_HUMANBioGRID, MINT28298427 details
AT2A2_HUMANPCNA_HUMANUniProt26030842 details
AT2A2_HUMANS10A1_HUMANBioGRID, HPRD12804600 details
AT2A2_HUMANPPLA_HUMANBioGRID, HPRD10809745 11526231 11854448 12032137 31046837 details
AT2A2_HUMANHGS_HUMANBioGRID19019082 details
AT2A2_HUMANOSTP_HUMANBioGRID22779921 details
AT2A2_HUMANMDM2_HUMANBioGRID24583282 details
AT2A2_HUMANTRI14_HUMANBioGRID29053956 details
AT2A2_HUMANTNR1A_HUMANIntAct14743216 details
AT2A2_HUMANTNR1B_HUMANIntAct14743216 details
AT2A2_HUMANTRADD_HUMANIntAct14743216 details
AT2A2_HUMANTRAF6_HUMANIntAct14743216 details
AT2A2_HUMANEGFR_HUMANBioGRID, IntAct15657067 23956138 24189400 details
AT2A2_HUMANMYC_HUMANBioGRID, IntAct17314511 17353931 29467282 details
AT2A2_HUMANCFTR_HUMANBioGRID, IntAct17110338 25661196 26618866 details
AT2A2_HUMANOPRD_HUMANMINT20528919 details
AT2A2_HUMANTNFA_HUMANIntAct20195357 details
AT2A2_HUMANLRRK2_HUMANBioGRID, IntAct24725412 31046837 details
AT2A2_HUMANMPTX_HUMANIntAct30021884 details
AT2A2_HUMANSARCO_HUMANBioGRID12032137 details
AT2A2_HUMANHDAC5_HUMANBioGRID21081666 details
AT2A2_HUMANTRI13_HUMANBioGRID17314412 details
AT2A2_HUMANHACD3_HUMANBioGRID25036637 details
AT2A2_HUMANSPRTN_HUMANBioGRID23254330 details
AT2A2_HUMANRN126_HUMANBioGRID26508657 details
AT2A2_HUMANNEPRO_HUMANBioGRID26472760 details
AT2A2_HUMANDERL1_HUMANBioGRID28137758 34079125 details
AT2A2_HUMANSIR1_HUMANBioGRID30786847 details
AT2A2_HUMANISG15_HUMANBioGRID33024031 details
AT2A2_HUMANBCL2_HUMANHPRD9788433 details
AT2A2_HUMANAT2A2_HUMANHPRD12670936 details
AT2A2_HUMANIRS1_HUMANHPRD9295312 details
AT2A2_HUMANIRS2_HUMANHPRD9295312 details