Entity Details

Primary name EGLN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17813
EntryNameEGLN_HUMAN
FullNameEndoglin
TaxID9606
Evidenceevidence at protein level
Length658
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesENG

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001837 epithelial to mesenchymal transition
GO:0001934 positive regulation of protein phosphorylation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001947 heart looping
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0003148 outflow tract septum morphogenesis
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003273 cell migration involved in endocardial cushion formation
GO:0004888 transmembrane signaling receptor activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005534 galactose binding
GO:0005539 glycosaminoglycan binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006355 regulation of transcription, DNA-templated
GO:0007155 cell adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0016604 nuclear body
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0022009 central nervous system vasculogenesis
GO:0022617 extracellular matrix disassembly
GO:0030155 regulation of cell adhesion
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0031953 negative regulation of protein autophosphorylation
GO:0031960 response to corticosteroid
GO:0032967 positive regulation of collagen biosynthetic process
GO:0034713 type I transforming growth factor beta receptor binding
GO:0035912 dorsal aorta morphogenesis
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042325 regulation of phosphorylation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048185 activin binding
GO:0048745 smooth muscle tissue development
GO:0048844 artery morphogenesis
GO:0048845 venous blood vessel morphogenesis
GO:0048870 cell motility
GO:0050431 transforming growth factor beta binding
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0060326 cell chemotaxis
GO:0060348 bone development
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0070278 extracellular matrix constituent secretion
GO:0070483 detection of hypoxia
GO:0071260 cellular response to mechanical stimulus
GO:0072563 endothelial microparticle
GO:0097084 vascular associated smooth muscle cell development
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905065 positive regulation of vascular associated smooth muscle cell differentiation
GO:1905222 atrioventricular canal morphogenesis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR001507 Zona pellucida domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB06322 CarotuximabDrugbankbiotech

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
EGLN_HUMANTGFB1_HUMANBioGRID, HPRD, I2D12015308 1326540 20856203 details
EGLN_HUMANA2GL_HUMANDIP23868260 details
EGLN_HUMANTGFR1_HUMANBioGRID, DIP, HPRD12015308 15702480 18974388 23868260 9872992 details
EGLN_HUMANKCAB1_HUMANUniProt31540324 details
EGLN_HUMANSRC8_HUMANUniProt31540324 details
EGLN_HUMANSMAP1_HUMANUniProt31540324 details
EGLN_HUMANF126B_HUMANUniProt31540324 details
EGLN_HUMANSCEL_HUMANUniProt31540324 details
EGLN_HUMANLEG3_HUMANBioGRID, UniProt31540324 details
EGLN_HUMANABLM1_HUMANUniProt31540324 details
EGLN_HUMANWASH2_HUMANUniProt31540324 details
EGLN_HUMANCAPR1_HUMANUniProt31540324 details
EGLN_HUMANYTHD2_HUMANUniProt31540324 details
EGLN_HUMANRO52_HUMANBioGRID, UniProt31540324 details
EGLN_HUMANSAFB2_HUMANUniProt31540324 details
EGLN_HUMANSH3R2_HUMANUniProt31540324 details
EGLN_HUMANABCF1_HUMANUniProt31540324 details
EGLN_HUMANCWC15_HUMANUniProt31540324 details
EGLN_HUMANHIRP3_HUMANUniProt31540324 details
EGLN_HUMANLMNA_HUMANUniProt31540324 details
EGLN_HUMANR51A1_HUMANUniProt31540324 details
EGLN_HUMANORC6_HUMANUniProt31540324 details
EGLN_HUMANRTF1_HUMANUniProt31540324 details
EGLN_HUMANNSRP1_HUMANUniProt31540324 details
EGLN_HUMANPRC2B_HUMANUniProt31540324 details
EGLN_HUMANTGFR2_HUMANBioGRID, HPRD12015308 15702480 9872992 details
EGLN_HUMANGDF2_HUMANBioGRID17311849 details
EGLN_HUMANDYLT4_HUMANHPRD16982625 details
EGLN_HUMANITA5_HUMANMINT22940691 details
EGLN_HUMANITB1_HUMANMINT22940691 details
EGLN_HUMANARRB2_HUMANMINT22940691 details
EGLN_HUMANMMP14_HUMANIntAct22296769 details
EGLN_HUMANACVL1_HUMANBioGRID, DIP, IntAct15702480 23868260 28564608 details
EGLN_HUMANEGLN_HUMANBioGRID, HPRD, IntAct1537377 15806144 28564608 details
EGLN_HUMANACVR1_HUMANBioGRID, HPRD9872992 details
EGLN_HUMANAVR2B_HUMANBioGRID9872992 details
EGLN_HUMANBMP7_HUMANBioGRID, HPRD9872992 details
EGLN_HUMANBMP2_HUMANBioGRID, HPRD9872992 details
EGLN_HUMANAVR2A_HUMANBioGRID, HPRD23967299 9872992 details
EGLN_HUMANTGFB3_HUMANBioGRID, HPRD1326540 9872992 details
EGLN_HUMANBMPR2_HUMANBioGRID23967299 details
EGLN_HUMANTGBR3_HUMANHPRD12568406 details
EGLN_HUMANINHBA_HUMANHPRD9872992 details
EGLN_HUMANTGFB2_HUMANHPRD12015308 details