Entity Details

Primary name LOX12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18054
EntryNameLOX12_HUMAN
FullNamePolyunsaturated fatty acid lipoxygenase ALOX12
TaxID9606
Evidenceevidence at protein level
Length663
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesALOX12

GO terms

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GOName
GO:0004052 arachidonate 12(S)-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006629 lipid metabolic process
GO:0007568 aging
GO:0010628 positive regulation of gene expression
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0016020 membrane
GO:0016165 linoleate 13S-lipoxygenase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0019395 fatty acid oxidation
GO:0033559 unsaturated fatty acid metabolic process
GO:0034440 lipid oxidation
GO:0042383 sarcolemma
GO:0042554 superoxide anion generation
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043651 linoleic acid metabolic process
GO:0047977 hepoxilin-epoxide hydrolase activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050473 arachidonate 15-lipoxygenase activity
GO:0051121 hepoxilin metabolic process
GO:0051122 hepoxilin biosynthetic process
GO:0051901 positive regulation of mitochondrial depolarization
GO:0061436 establishment of skin barrier
GO:0070062 extracellular exosome
GO:0071396 cellular response to lipid
GO:0090331 negative regulation of platelet aggregation
GO:1901751 leukotriene A4 metabolic process
GO:1905956 positive regulation of endothelial tube morphogenesis
GO:2001301 lipoxin biosynthetic process
GO:2001303 lipoxin A4 biosynthetic process
GO:2001306 lipoxin B4 biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000907 LipoxygenaseFamilyFamily
IPR001024 PLAT/LH2 domainDomainDomain
IPR001885 Lipoxygenase, mammalianFamilyFamily
IPR013819 Lipoxygenase, C-terminalDomainDomain
IPR020833 Lipoxygenase, iron binding siteSiteBinding site
IPR020834 Lipoxygenase, conserved siteSiteConserved site
IPR036226 Lipoxigenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036392 PLAT/LH2 domain superfamilyFamilyHomologous superfamily
IPR042062 Lipoxygenase, vertebrates, PLAT domainDomainDomain

Diseases

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