Entity Details

Primary name ERCC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19447
EntryNameERCC3_HUMAN
FullNameGeneral transcription and DNA repair factor IIH helicase subunit XPB
TaxID9606
Evidenceevidence at protein level
Length782
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesERCC3

GO terms

Show/Hide Table
GOName
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0006265 DNA topological change
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0008022 protein C-terminus binding
GO:0008104 protein localization
GO:0008134 transcription factor binding
GO:0009411 response to UV
GO:0016032 viral process
GO:0016887 ATP hydrolysis activity
GO:0033683 nucleotide-excision repair, DNA incision
GO:0035315 hair cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0043138 3'-5' DNA helicase activity
GO:0047485 protein N-terminus binding
GO:0048568 embryonic organ development
GO:0070911 global genome nucleotide-excision repair
GO:0097550 transcription preinitiation complex
GO:1901990 regulation of mitotic cell cycle phase transition

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001161 Helicase XPB/Ssl2FamilyFamily
IPR001650 Helicase, C-terminalDomainDomain
IPR006935 Helicase/UvrB, N-terminalDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032438 ERCC3/RAD25/XPB helicase, C-terminal domainDomainDomain
IPR032830 Helicase XPB/Ssl2, N-terminal domainDomainDomain

Diseases

Show/Hide Table

Interactions

53 interactions

InteractorPartnerSourcesPublicationsLink
ERCC3_HUMANPRS8_HUMANBioGRID, HPRD, IntAct9173976 details
ERCC3_HUMANANDR_HUMANBioGRID, MINT21157430 details
ERCC3_HUMANGOGA2_HUMANBioGRID, MINT21516116 details
ERCC3_HUMANIMA4_HUMANBioGRID, IntAct21988832 32296183 details
ERCC3_HUMANMSD2_HUMANBioGRID, IntAct21988832 details
ERCC3_HUMANXPC_HUMANBioGRID, DIP, HPRD, UniProt10734143 26278177 details
ERCC3_HUMANCDK7_HUMANBioGRID, HPRD, IntAct10082552 15220921 17643375 23602568 26340423 28514442 28977422 29568061 8521393 8692841 9130708 details
ERCC3_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
ERCC3_HUMANXIAP_HUMANBioGRID, IntAct25416956 31515488 details
ERCC3_HUMANCEP70_HUMANBioGRID, IntAct25416956 details
ERCC3_HUMANTF2H5_HUMANBioGRID, DIP, HPRD, IntAct15220921 16669699 19172752 24981860 26340423 26496610 28514442 details
ERCC3_HUMANMAGD1_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANCEP76_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANATL4_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANROP1A_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANFXR1_HUMANIntAct32296183 details
ERCC3_HUMANGO45_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANSNW1_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANTRI14_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANTRI27_HUMANBioGRID, IntAct31515488 32296183 details
ERCC3_HUMANTF2H4_HUMANBioGRID, DIP, HPRD, IntAct15220921 19172752 22939629 24981860 26340423 26344197 28514442 9118947 details
ERCC3_HUMANTF2H2_HUMANBioGRID, HPRD, IntAct15220921 17643375 19934020 24981860 26340423 26344197 28514442 28977422 8194529 9118947 details
ERCC3_HUMANMAT1_HUMANBioGRID, HPRD, IntAct15220921 17643375 26340423 28514442 8692842 9118947 details
ERCC3_HUMANBCR_HUMANBioGRID, HPRD, IntAct10403766 17643375 28514442 9874796 details
ERCC3_HUMANERCC2_HUMANBioGRID, DIP, HPRD, IntAct15220921 16669699 19934020 22678362 22939629 26340423 27193682 8152490 8652557 9118947 details
ERCC3_HUMANEFHC2_HUMANIntAct31515488 details
ERCC3_HUMANZSCA1_HUMANBioGRID, IntAct20211142 details
ERCC3_HUMANT2EA_HUMANBioGRID, HPRD25492609 7926747 8152490 details
ERCC3_HUMANT2EB_HUMANBioGRID, HPRD7926747 8152490 details
ERCC3_HUMANP53_HUMANBioGRID, HPRD12379483 32807901 7663514 8612585 details
ERCC3_HUMANE2F1_HUMANBioGRID9400991 details
ERCC3_HUMANCDK8_HUMANBioGRID10993082 details
ERCC3_HUMANCCNC_HUMANBioGRID10993082 details
ERCC3_HUMANMCF2_HUMANBioGRID10403766 details
ERCC3_HUMANCDC42_HUMANBioGRID10403766 details
ERCC3_HUMANTF2H1_HUMANBioGRID, HPRD, IntAct10403766 11259578 15220921 17643375 19934020 22939629 24981860 26340423 26344197 28514442 8194528 8652557 8692842 9118947 9130708 9173976 details
ERCC3_HUMANSMAD2_HUMANIntAct20195357 details
ERCC3_HUMANCCNH_HUMANBioGRID, HPRD, IntAct, UniProt10734143 15220921 17643375 19934020 26186194 26340423 28514442 8692842 9118947 details
ERCC3_HUMANRD23B_HUMANUniProt10734143 details
ERCC3_HUMANMLF1_HUMANIntAct25036637 details
ERCC3_HUMANMLF2_HUMANIntAct25036637 details
ERCC3_HUMANCHIP_HUMANIntAct25036637 details
ERCC3_HUMANTF2H3_HUMANBioGRID, HPRD, IntAct, MINT15220921 17643375 22939629 24981860 26340423 26344197 28514442 8194529 9118947 details
ERCC3_HUMANMCAF1_HUMANBioGRID19106100 details
ERCC3_HUMANRPB1_HUMANBioGRID16916636 32355176 details
ERCC3_HUMANERPG3_HUMANBioGRID16916636 details
ERCC3_HUMANERCC6_HUMANBioGRID16916636 details
ERCC3_HUMANCSN2_HUMANBioGRID17438371 details
ERCC3_HUMANMMS19_HUMANBioGRID11071939 details
ERCC3_HUMANRAD52_HUMANBioGRID, HPRD12372413 details
ERCC3_HUMANUVSSA_HUMANBioGRID22902626 32355176 details
ERCC3_HUMANUBXN7_HUMANBioGRID26389662 details
ERCC3_HUMANSPTA1_HUMANBioGRID16889989 details