Entity Details

Primary name TFE3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19532
EntryNameTFE3_HUMAN
FullNameTranscription factor E3
TaxID9606
Evidenceevidence at protein level
Length575
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesTFE3

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002250 adaptive immune response
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006959 humoral immune response
GO:0045670 regulation of osteoclast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0090336 positive regulation of brown fat cell differentiation
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR021802 MiT/TFE transcription factors, C-terminalDomainDomain
IPR024100 Transcription factor E3FamilyFamily
IPR031867 MiT/TFE transcription factors, N-terminalDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
TFE3_HUMANLTOR3_HUMANBioGRID, IntAct32296183 details
TFE3_HUMANE2F3_HUMANBioGRID, HPRD12748276 details
TFE3_HUMANSMCE1_HUMANBioGRID11018012 details
TFE3_HUMANTFE3_HUMANBioGRID, HPRD2044953 details
TFE3_HUMANSMAD3_HUMANBioGRID, HPRD10557285 10973944 12551947 details
TFE3_HUMANSMAD4_HUMANBioGRID, HPRD10557285 12551947 details
TFE3_HUMANTFEC_HUMANBioGRID, HPRD11467950 8336698 details
TFE3_HUMANPSA6_HUMANIntAct17353931 details
TFE3_HUMANDHX9_HUMANIntAct17353931 details
TFE3_HUMANTERA_HUMANIntAct17353931 details
TFE3_HUMANPSA3_HUMANIntAct17353931 details
TFE3_HUMANNASP_HUMANIntAct17353931 details
TFE3_HUMANSYMC_HUMANIntAct17353931 details
TFE3_HUMANECHM_HUMANIntAct17353931 details
TFE3_HUMANPSMD1_HUMANIntAct17353931 details
TFE3_HUMANGANAB_HUMANIntAct17353931 details
TFE3_HUMANGSTM3_HUMANIntAct17353931 details
TFE3_HUMANCYBP_HUMANIntAct17353931 details
TFE3_HUMANEIF3I_HUMANIntAct17353931 details
TFE3_HUMANNP1L1_HUMANIntAct17353931 details
TFE3_HUMANPP2AB_HUMANIntAct17353931 details
TFE3_HUMANSPSY_HUMANIntAct17353931 details
TFE3_HUMANPSA1_HUMANIntAct17353931 details
TFE3_HUMANFSCN1_HUMANIntAct17353931 details
TFE3_HUMANNU155_HUMANIntAct17353931 details
TFE3_HUMANLPPRC_HUMANIntAct17353931 details
TFE3_HUMANSET_HUMANIntAct17353931 details
TFE3_HUMANPDC6I_HUMANIntAct17353931 details
TFE3_HUMANSMC2_HUMANIntAct17353931 details
TFE3_HUMANRPGR1_HUMANIntAct17353931 details
TFE3_HUMANTFEB_HUMANBioGRID, HPRD, IntAct26496610 28514442 9806910 details
TFE3_HUMANMITF_HUMANBioGRID, HPRD, IntAct11818452 11930005 28514442 details
TFE3_HUMAN1433G_HUMANHPRD, IntAct15324660 28514442 details
TFE3_HUMANIPO8_HUMANDIP26168401 details
TFE3_HUMANHMGB1_HUMANHPRD11748221 details