Entity Details

Primary name SL9A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19634
EntryNameSL9A1_HUMAN
FullNameSodium/hydrogen exchanger 1
TaxID9606
Evidenceevidence at protein level
Length815
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesSLC9A1

GO terms

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GOName
GO:0005516 calmodulin binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006811 ion transport
GO:0006883 cellular sodium ion homeostasis
GO:0006885 regulation of pH
GO:0009986 cell surface
GO:0010447 response to acidic pH
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014704 intercalated disc
GO:0015299 solute:proton antiporter activity
GO:0015385 sodium:proton antiporter activity
GO:0015386 potassium:proton antiporter activity
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016477 cell migration
GO:0030011 maintenance of cell polarity
GO:0030027 lamellipodium
GO:0030214 hyaluronan catabolic process
GO:0030307 positive regulation of cell growth
GO:0030315 T-tubule
GO:0030346 protein phosphatase 2B binding
GO:0030674 protein-macromolecule adaptor activity
GO:0032869 cellular response to insulin stimulus
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0035994 response to muscle stretch
GO:0036376 sodium ion export across plasma membrane
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045121 membrane raft
GO:0045760 positive regulation of action potential
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048306 calcium-dependent protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0051259 protein complex oligomerization
GO:0051453 regulation of intracellular pH
GO:0051492 regulation of stress fiber assembly
GO:0051893 regulation of focal adhesion assembly
GO:0051930 regulation of sensory perception of pain
GO:0055007 cardiac muscle cell differentiation
GO:0060090 molecular adaptor activity
GO:0070062 extracellular exosome
GO:0070417 cellular response to cold
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0070997 neuron death
GO:0071236 cellular response to antibiotic
GO:0071257 cellular response to electrical stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071456 cellular response to hypoxia
GO:0071468 cellular response to acidic pH
GO:0071805 potassium ion transmembrane transport
GO:0071872 cellular response to epinephrine stimulus
GO:0086003 cardiac muscle cell contraction
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0086040 sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
GO:0086092 regulation of the force of heart contraction by cardiac conduction
GO:0090533 cation-transporting ATPase complex
GO:0098719 sodium ion import across plasma membrane
GO:0098735 positive regulation of the force of heart contraction
GO:1902600 proton transmembrane transport
GO:1903281 positive regulation of calcium:sodium antiporter activity

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Membrane

Domains

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DomainNameCategoryType
IPR001970 Na+/H+ exchanger, isoform 1 (NHE1)FamilyFamily
IPR004709 Na+/H+ exchangerFamilyFamily
IPR006153 Cation/H+ exchangerDomainDomain
IPR018422 Cation/H+ exchanger, CPA1 familyFamilyFamily
IPR032103 Sodium/hydrogen exchanger, regulatory regionDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00594 AmilorideDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB02624 Homoserine LactoneDrugbanksmall molecule
DB06468 CariporideDrugbanksmall molecule