Entity Details

Primary name CD33_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20138
EntryNameCD33_HUMAN
FullNameMyeloid cell surface antigen CD33
TaxID9606
Evidenceevidence at protein level
Length364
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesCD33

GO terms

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GOName
GO:0002765 immune response-inhibiting signal transduction
GO:0005654 nucleoplasm
GO:0005777 peroxisome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008285 negative regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0019903 protein phosphatase binding
GO:0030246 carbohydrate binding
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033691 sialic acid binding
GO:0035579 specific granule membrane
GO:0038023 signaling receptor activity
GO:0043312 neutrophil degranulation
GO:0050714 positive regulation of protein secretion
GO:0050776 regulation of immune response
GO:0051926 negative regulation of calcium ion transport
GO:0070821 tertiary granule membrane
GO:0098609 cell-cell adhesion
GO:0150102 negative regulation of monocyte activation
GO:1903615 positive regulation of protein tyrosine phosphatase activity

Subcellular Location

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Subcellular Location
Cell membrane
Peroxisome

Domains

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DomainNameCategoryType
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00056 Gemtuzumab ozogamicinDrugbankbiotech
DB06318 AVE9633Drugbankbiotech

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
CD33_HUMANPTN6_HUMANBioGRID, HPRD, MINT, UniProt10206955 10556798 17947393 24216507 details
CD33_HUMANPTN11_HUMANBioGRID, HPRD, MINT10206955 17947393 details
CD33_HUMANHERC3_HUMANBioGRID, IntAct21988832 details
CD33_HUMANK1H1_HUMANBioGRID, IntAct25416956 32296183 details
CD33_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
CD33_HUMANEMD_HUMANBioGRID, IntAct32296183 details
CD33_HUMANRPRM_HUMANBioGRID, IntAct32296183 details
CD33_HUMANUBIA1_HUMANBioGRID, IntAct32296183 details
CD33_HUMANBMP10_HUMANBioGRID, IntAct32296183 details
CD33_HUMANLFG3_HUMANBioGRID, IntAct32296183 details
CD33_HUMANSCD_HUMANBioGRID, IntAct32296183 details
CD33_HUMANCYB5B_HUMANBioGRID, IntAct32296183 details
CD33_HUMANTM243_HUMANBioGRID, IntAct32296183 details
CD33_HUMANTHS7A_HUMANBioGRID, IntAct32296183 details
CD33_HUMANTNMD_HUMANBioGRID, IntAct32296183 details
CD33_HUMANTM100_HUMANBioGRID, IntAct32296183 details
CD33_HUMANKRT35_HUMANBioGRID, IntAct32296183 details
CD33_HUMANGIMA5_HUMANBioGRID, IntAct32296183 details
CD33_HUMANCXCL9_HUMANBioGRID, IntAct32296183 details
CD33_HUMANTTMP_HUMANBioGRID, IntAct32296183 details
CD33_HUMANTLR10_HUMANIntAct25187624 details
CD33_HUMANTLR5_HUMANIntAct25187624 details
CD33_HUMANLEP_HUMANIntAct10428856 details
CD33_HUMANS10A9_HUMANUniProt24216507 details
CD33_HUMANLAIR1_HUMANIntAct28325905 details
CD33_HUMANCD14_HUMANIntAct28325905 details
CD33_HUMANCBL_HUMANBioGRID18062779 details
CD33_HUMANSRC_HUMANHPRD10206955 details