Entity Details

Primary name CCNA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20248
EntryNameCCNA2_HUMAN
FullNameCyclin-A2
TaxID9606
Evidenceevidence at protein level
Length432
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesCCNA2

GO terms

Show/Hide Table
GOName
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006275 regulation of DNA replication
GO:0007265 Ras protein signal transduction
GO:0016032 viral process
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0016572 histone phosphorylation
GO:0016579 protein deubiquitination
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0031100 animal organ regeneration
GO:0033762 response to glucagon
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0044320 cellular response to leptin stimulus
GO:0044772 mitotic cell cycle phase transition
GO:0044843 cell cycle G1/S phase transition
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048146 positive regulation of fibroblast proliferation
GO:0051301 cell division
GO:0071314 cellular response to cocaine
GO:0071373 cellular response to luteinizing hormone stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071732 cellular response to nitric oxide
GO:0090102 cochlea development
GO:0097124 cyclin A2-CDK2 complex
GO:1990314 cellular response to insulin-like growth factor stimulus

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR004367 Cyclin, C-terminal domainDomainDomain
IPR006671 Cyclin, N-terminalDomainDomain
IPR013763 Cyclin-likeDomainDomain
IPR032447 Cyclin-A, N-terminalDomainDomain
IPR036915 Cyclin-like superfamilyFamilyHomologous superfamily
IPR039361 CyclinFamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB02091 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-YlamineDrugbanksmall molecule
DB02407 6-O-Cyclohexylmethyl GuanineDrugbanksmall molecule
DB02833 [4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-AmineDrugbanksmall molecule
DB02915 4-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrimidinamineDrugbanksmall molecule
DB06844 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDEDrugbanksmall molecule
DB06944 N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamideDrugbanksmall molecule
DB06948 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINEDrugbanksmall molecule
DB07126 O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINEDrugbanksmall molecule
DB07137 (2S)-N-[(3E)-5-Cyclopropyl-3H-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)phenyl]propanamideDrugbanksmall molecule
DB07164 N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amineDrugbanksmall molecule
DB07203 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINEDrugbanksmall molecule
DB07471 5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDEDrugbanksmall molecule
DB07533 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDEDrugbanksmall molecule
DB07534 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDEDrugbanksmall molecule
DB07538 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDEDrugbanksmall molecule
DB07539 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACIDDrugbanksmall molecule
DB07562 N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINEDrugbanksmall molecule
DB07688 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDEDrugbanksmall molecule
DB07852 1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACIDDrugbanksmall molecule
DB08178 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineDrugbanksmall molecule
DB08182 4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amineDrugbanksmall molecule
DB08218 HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUMDrugbanksmall molecule
DB08219 4-Methyl-5-[(2Z)-2-{[4-(4-morpholinyl)phenyl]imino}-2,5-dihydro-4-pyrimidinyl]-1,3-thiazol-2-amineDrugbanksmall molecule
DB08233 6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINEDrugbanksmall molecule
DB08241 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDEDrugbanksmall molecule
DB08248 3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDEDrugbanksmall molecule
DB08285 (2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-olDrugbanksmall molecule
DB08309 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OLDrugbanksmall molecule
DB08355 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acidDrugbanksmall molecule
DB08463 (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-olDrugbanksmall molecule
DB08527 1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDEDrugbanksmall molecule
DB08572 4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDEDrugbanksmall molecule
DB08694 Variolin BDrugbanksmall molecule

Interactions

90 interactions

InteractorPartnerSourcesPublicationsLink
CCNA2_HUMANCDT1_HUMANBioGRID, HPRD, IntAct14993212 18184650 26186194 26496610 28514442 31160578 details
CCNA2_HUMANCAF1A_HUMANMINT16826239 details
CCNA2_HUMANCDK2_HUMANBioGRID, DIP, HPRD, IntAct10924145 11377199 11907280 11940657 11983168 12044161 12244298 12853968 12941338 14656438 15189033 15239650 15455144 15557281 15647383 15828833 15890360 16209941 16290148 16431923 17254966 17361108 18177895 18471975 19483727 19631451 19773423 20733051 21241890 21447625 22231403 23455922 23602568 24302728 24358021 25669885 25852190 26186194 26496610 28514442 33854235 7553852 7630397 8397207 8463339 8475101 8662825 8684460 8756328 9380407 9660939 9716181 9724724 details
CCNA2_HUMANCDN1B_HUMANBioGRID, DIP, HPRD, IntAct12501191 12947099 15890360 16209941 17254966 18177895 20596027 24632684 26186194 26496610 27720894 28514442 31822694 8684460 9311993 9660939 9716181 9724724 details
CCNA2_HUMANDTBP1_HUMANBioGRID, IntAct17043677 details
CCNA2_HUMANCDN1A_HUMANBioGRID, HPRD, IntAct12947099 15890360 17679094 21308745 23443559 26186194 26496610 28514442 30833792 8662825 8756624 9380407 9632134 9660939 details
CCNA2_HUMANRBL2_HUMANBioGRID, HPRD, IntAct12006580 17531812 26186194 28514442 8253383 details
CCNA2_HUMANRB_HUMANBioGRID, IntAct10486249 12676926 19249677 8626527 8647086 9053846 9190208 9219533 9885575 details
CCNA2_HUMANE2F1_HUMANBioGRID, HPRD, IntAct, NTNU12501191 16179649 19249677 7969176 8458319 9724724 details
CCNA2_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
CCNA2_HUMANSKP2_HUMANBioGRID, HPRD, IntAct10559858 15355997 16209941 18604603 20160477 24632684 26186194 26496610 27720894 28514442 31181401 7553852 9858587 details
CCNA2_HUMANCDC20_HUMANBioGRID, HPRD, IntAct10679238 18471975 19098431 19483727 19826003 20733051 23007648 25306918 25669885 25750436 26186194 26496610 26811472 26960431 27522463 28514442 31455778 32152539 32307883 details
CCNA2_HUMANHSC20_HUMANDIP24606901 details
CCNA2_HUMANFZR1_HUMANBioGRID, IntAct18485873 19483727 21700221 26186194 27653696 28514442 31455778 31489637 details
CCNA2_HUMANRBL1_HUMANBioGRID, HPRD, IntAct12439743 1532458 26186194 28514442 8230483 8491188 8798463 9724724 details
CCNA2_HUMANCDK7_HUMANBioGRID, IntAct11113184 16327805 26186194 28514442 details
CCNA2_HUMANMIPT3_HUMANBioGRID, IntAct17043677 31413325 details
CCNA2_HUMANBRCA1_HUMANBioGRID, HPRD10373534 25091198 9244350 details
CCNA2_HUMANCALM1_HUMANBioGRID14695896 details
CCNA2_HUMANCALM2_HUMANBioGRID14695896 details
CCNA2_HUMANCALM3_HUMANBioGRID14695896 details
CCNA2_HUMANFEN1_HUMANBioGRID12853968 details
CCNA2_HUMANCDC6_HUMANBioGRID, HPRD10339564 9566895 9889196 details
CCNA2_HUMANHERC5_HUMANBioGRID, HPRD10581175 details
CCNA2_HUMANP53_HUMANBioGRID, HPRD10884347 details
CCNA2_HUMANCENPR_HUMANBioGRID, HPRD10673397 details
CCNA2_HUMANRFA1_HUMANBioGRID8798463 details
CCNA2_HUMANSP1_HUMANBioGRID11237594 11598016 16575904 details
CCNA2_HUMANKAT2B_HUMANBioGRID19483727 details
CCNA2_HUMANARI4A_HUMANBioGRID21148318 details
CCNA2_HUMANH11_HUMANBioGRID11940657 19631451 22158041 8647086 9053846 9380407 9885575 details
CCNA2_HUMANUBP37_HUMANBioGRID21596315 details
CCNA2_HUMANPSMD4_HUMANBioGRID18485873 details
CCNA2_HUMANRD23A_HUMANBioGRID18485873 details
CCNA2_HUMANPRC1_HUMANBioGRID9885575 details
CCNA2_HUMANBRCA2_HUMANBioGRID, HPRD15800615 15800651 details
CCNA2_HUMANH15_HUMANBioGRID15800615 8662825 details
CCNA2_HUMANP73_HUMANBioGRID12676926 details
CCNA2_HUMANNFYA_HUMANBioGRID12857729 details
CCNA2_HUMANCTNB1_HUMANBioGRID14985333 details
CCNA2_HUMANDPOLA_HUMANBioGRID11259605 details
CCNA2_HUMANMD2L1_HUMANBioGRID25669885 details
CCNA2_HUMANBUB1B_HUMANBioGRID25669885 details
CCNA2_HUMANFANCC_HUMANBioGRID24676280 details
CCNA2_HUMANMAGAB_HUMANBioGRID27720894 details
CCNA2_HUMANORC1_HUMANBioGRID, IntAct11931757 26186194 26496610 28514442 31160578 details
CCNA2_HUMANORC2_HUMANBioGRID, IntAct11931757 31160578 details
CCNA2_HUMANCDK1_HUMANBioGRID, HPRD, IntAct10924145 12853968 17679094 19483727 21308745 23602568 24302728 25852190 26186194 26496610 28514442 8463339 9053846 details
CCNA2_HUMANCDK3_HUMANBioGRID, HPRD, IntAct23602568 26186194 28514442 8626584 details
CCNA2_HUMANCCNB1_HUMANIntAct23397142 details
CCNA2_HUMANCKS1_HUMANBioGRID, IntAct11907280 16209941 18471975 19483727 26186194 26496610 28514442 details
CCNA2_HUMANSKP1_HUMANBioGRID, HPRD, IntAct16209941 26496610 9858587 details
CCNA2_HUMANCDN1C_HUMANBioGRID, IntAct12947099 26186194 26496610 28514442 details
CCNA2_HUMANSAMH1_HUMANBioGRID, IntAct24623419 26186194 28514442 30068654 details
CCNA2_HUMANPHF8_HUMANBioGRID, IntAct26186194 28514442 33010150 details
CCNA2_HUMANCKS2_HUMANBioGRID, IntAct18471975 19483727 26186194 28514442 details
CCNA2_HUMANPCNA_HUMANBioGRID, IntAct12853968 26186194 28514442 details
CCNA2_HUMANAKT1_HUMANDIP24670654 details
CCNA2_HUMANAKT3_HUMANDIP24670654 details
CCNA2_HUMANAKT2_HUMANDIP24670654 details
CCNA2_HUMANK2C1_HUMANBioGRID17361108 details
CCNA2_HUMANPSA6_HUMANBioGRID22158041 details
CCNA2_HUMANCDK6_HUMANBioGRID9716181 details
CCNA2_HUMANCDK4_HUMANBioGRID24302728 9716181 details
CCNA2_HUMANAPC4_HUMANBioGRID21336306 25669885 25750436 details
CCNA2_HUMANCCNA2_HUMANBioGRID21308745 details
CCNA2_HUMANTRI33_HUMANBioGRID23160376 details
CCNA2_HUMANNFYB_HUMANBioGRID12857729 details
CCNA2_HUMANBIRC6_HUMANBioGRID24302728 details
CCNA2_HUMANAPC11_HUMANBioGRID24302728 details
CCNA2_HUMANCADH2_HUMANBioGRID22152476 details
CCNA2_HUMANCDC27_HUMANBioGRID19483727 32076268 details
CCNA2_HUMANSLBP_HUMANBioGRID27773672 28118078 details
CCNA2_HUMANPA24A_HUMANBioGRID26303530 details
CCNA2_HUMANGATA2_HUMANBioGRID17255359 details
CCNA2_HUMANDTL_HUMANBioGRID29424068 details
CCNA2_HUMANEXO1_HUMANBioGRID24705021 details
CCNA2_HUMANMRE11_HUMANBioGRID22231403 details
CCNA2_HUMANU17L2_HUMANBioGRID30935108 details
CCNA2_HUMANLRWD1_HUMANBioGRID31160578 details
CCNA2_HUMANFBXL6_HUMANBioGRID31181401 details
CCNA2_HUMANHIRA_HUMANHPRD11238922 details
CCNA2_HUMANMPIP3_HUMANHPRD10864927 details
CCNA2_HUMANPTMA_HUMANHPRD11310559 details
CCNA2_HUMANTAF1_HUMANHPRD9660973 details
CCNA2_HUMANE2F3_HUMANHPRD11980909 details
CCNA2_HUMANUBF1_HUMANHPRD11698641 details
CCNA2_HUMANMYBB_HUMANHPRD10871850 details
CCNA2_HUMANBTG1_HUMANHPRD9820826 details
CCNA2_HUMANPRGR_HUMANHPRD15601848 details