Entity Details

Primary name CAN3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20807
EntryNameCAN3_HUMAN
FullNameCalpain-3
TaxID9606
Evidenceevidence at protein level
Length821
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesCAPN3

GO terms

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GOName
GO:0003824 catalytic activity
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005622 intracellular anatomical structure
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0007517 muscle organ development
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008307 structural constituent of muscle
GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration
GO:0014850 response to muscle activity
GO:0030016 myofibril
GO:0030018 Z disc
GO:0030163 protein catabolic process
GO:0030239 myofibril assembly
GO:0030315 T-tubule
GO:0031402 sodium ion binding
GO:0031432 titin binding
GO:0031648 protein destabilization
GO:0032991 protein-containing complex
GO:0033234 negative regulation of protein sumoylation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045214 sarcomere organization
GO:0045661 regulation of myoblast differentiation
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046716 muscle cell cellular homeostasis
GO:0050790 regulation of catalytic activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051592 response to calcium ion
GO:0055103 ligase regulator activity
GO:0060090 molecular adaptor activity
GO:0061061 muscle structure development
GO:0065003 protein-containing complex assembly
GO:0070315 G1 to G0 transition involved in cell differentiation
GO:0071277 cellular response to calcium ion
GO:0071472 cellular response to salt stress
GO:0072657 protein localization to membrane
GO:0097264 self proteolysis
GO:1990092 calcium-dependent self proteolysis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR001300 Peptidase C2, calpain, catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR022682 Peptidase C2, calpain, large subunit, domain IIIDomainDomain
IPR022683 Peptidase C2, calpain, domain IIIDomainDomain
IPR022684 Peptidase C2, calpain familyFamilyFamily
IPR029531 Calpain-3FamilyFamily
IPR033883 Calpain subdomain IIIDomainDomain
IPR036213 Calpain large subunit, domain III superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06124 L-aminocarnityl-succinyl-leucyl-argininal-diethylacetalDrugbanksmall molecule

Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
CAN3_HUMANTITIN_HUMANBioGRID, HPRD, IntAct, MINT10987085 20860623 23414517 8537379 9185618 9642272 9763216 details
CAN3_HUMANCRYAB_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANPOMP_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANC1T9A_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANAMOT_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANFND3B_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANCMYA5_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANMYBPH_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANMYPC1_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANMMP2_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANPRS6A_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANPPCEL_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANRN167_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANPSMD1_HUMANBioGRID, IntAct23414517 details
CAN3_HUMANCAN3_HUMANBioGRID, HPRD, IntAct, MINT15073171 24846670 32296183 details
CAN3_HUMANNTAQ1_HUMANBioGRID, IntAct25416956 32296183 details
CAN3_HUMANOSGI1_HUMANBioGRID, IntAct25416956 31515488 details
CAN3_HUMANTFCP2_HUMANBioGRID, IntAct26871637 details
CAN3_HUMANEXOC8_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANZN410_HUMANIntAct32296183 details
CAN3_HUMANVEZF1_HUMANIntAct32296183 details
CAN3_HUMANBYST_HUMANIntAct32296183 details
CAN3_HUMANECHP_HUMANIntAct32296183 details
CAN3_HUMANGTPB3_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANC102B_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANRUFY3_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANKANK2_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANMLP3C_HUMANBioGRID, IntAct32296183 details
CAN3_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
CAN3_HUMANCASP6_HUMANIntAct32814053 details
CAN3_HUMANCLAT_HUMANIntAct32814053 details
CAN3_HUMANFGFR3_HUMANIntAct32814053 details
CAN3_HUMANGELS_HUMANIntAct32814053 details
CAN3_HUMANLAMP2_HUMANIntAct32814053 details
CAN3_HUMANRAN_HUMANIntAct32814053 details
CAN3_HUMANUBQL1_HUMANIntAct32814053 details
CAN3_HUMANSHLB1_HUMANIntAct32814053 details
CAN3_HUMANPR40A_HUMANIntAct32814053 details
CAN3_HUMANNECA2_HUMANBioGRID, HPRD16189514 details
CAN3_HUMANFLNC_HUMANBioGRID, HPRD14506720 details
CAN3_HUMANCEP76_HUMANBioGRID26871637 details
CAN3_HUMANTRI55_HUMANBioGRID31391242 details
CAN3_HUMANTRI54_HUMANIntAct31391242 details
CAN3_HUMANFXR1_HUMANMINT21653829 details
CAN3_HUMANUBE3A_HUMANMINT21653829 details
CAN3_HUMAN1433T_HUMANHPRD15324660 details
CAN3_HUMANDYSF_HUMANHPRD15827562 details