Entity Details

Primary name S1PR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21453
EntryNameS1PR1_HUMAN
FullNameSphingosine 1-phosphate receptor 1
TaxID9606
Evidenceevidence at protein level
Length382
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesS1PR1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001664 G protein-coupled receptor binding
GO:0001955 blood vessel maturation
GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0004930 G protein-coupled receptor activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0006935 chemotaxis
GO:0007155 cell adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007420 brain development
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0019222 regulation of metabolic process
GO:0019226 transmission of nerve impulse
GO:0030032 lamellipodium assembly
GO:0030155 regulation of cell adhesion
GO:0030182 neuron differentiation
GO:0030335 positive regulation of cell migration
GO:0030500 regulation of bone mineralization
GO:0030595 leukocyte chemotaxis
GO:0031226 intrinsic component of plasma membrane
GO:0031532 actin cytoskeleton reorganization
GO:0038036 sphingosine-1-phosphate receptor activity
GO:0043231 intracellular membrane-bounded organelle
GO:0043547 positive regulation of GTPase activity
GO:0045121 membrane raft
GO:0045124 regulation of bone resorption
GO:0045446 endothelial cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046625 sphingolipid binding
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050927 positive regulation of positive chemotaxis
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051497 negative regulation of stress fiber assembly
GO:0061384 heart trabecula morphogenesis
GO:0072678 T cell migration

Subcellular Location

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Subcellular Location
Cell membrane
Endosome
Membrane raft

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000987 EDG-1 sphingosine 1-phosphate receptorFamilyFamily
IPR004061 Sphingosine 1-phosphate receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB08868 FingolimodDrugbanksmall molecule
DB09105 Asfotase alfaDrugbankbiotech
DB12371 SiponimodDrugbanksmall molecule
DB12612 OzanimodDrugbanksmall molecule