Entity Details

Primary name DRD5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21918
EntryNameDRD5_HUMAN
FullNameD(1B) dopamine receptor
TaxID9606
Evidenceevidence at protein level
Length477
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesDRD5

GO terms

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GOName
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs
GO:0001963 synaptic transmission, dopaminergic
GO:0001975 response to amphetamine
GO:0001992 regulation of systemic arterial blood pressure by vasopressin
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004952 dopamine neurotransmitter receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0008306 associative learning
GO:0019226 transmission of nerve impulse
GO:0031526 brush border membrane
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0035240 dopamine binding
GO:0042060 wound healing
GO:0042220 response to cocaine
GO:0045202 synapse
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045776 negative regulation of blood pressure
GO:0045924 regulation of female receptivity
GO:0046960 sensitization
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060170 ciliary membrane
GO:0060292 long-term synaptic depression
GO:0071870 cellular response to catecholamine stimulus
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0072593 reactive oxygen species metabolic process
GO:0097730 non-motile cilium

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000497 Dopamine D5 receptorFamilyFamily
IPR000929 Dopamine receptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00246 ZiprasidoneDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00800 FenoldopamDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01038 CarphenazineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01235 LevodopaDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01624 ZuclopenthixolDrugbanksmall molecule
DB05271 RotigotineDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB09097 QuinagolideDrugbanksmall molecule
DB09225 ZotepineDrugbanksmall molecule
DB11274 Dihydro-alpha-ergocryptineDrugbanksmall molecule
DB11275 EpicriptineDrugbanksmall molecule
DB11584 PipradrolDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule