Entity Details

Primary name MAOM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23368
EntryNameMAOM_HUMAN
FullNameNAD-dependent malic enzyme, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length584
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesME2

GO terms

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GOName
GO:0004470 malic enzyme activity
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006090 pyruvate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0006108 malate metabolic process
GO:0008948 oxaloacetate decarboxylase activity
GO:0009055 electron transfer activity
GO:0043231 intracellular membrane-bounded organelle
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:1902031 regulation of NADP metabolic process

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR001891 Malic oxidoreductaseFamilyFamily
IPR012301 Malic enzyme, N-terminal domainDomainDomain
IPR012302 Malic enzyme, NAD-bindingDomainDomain
IPR015884 Malic enzyme, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily
IPR037062 Malic enzyme, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB01677 Fumaric AcidDrugbanksmall molecule
DB03499 D-Malic acidDrugbanksmall molecule
DB03589 Mesoxalic acidDrugbanksmall molecule
DB03680 TartronateDrugbanksmall molecule