Entity Details

Primary name COF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23528
EntryNameCOF1_HUMAN
FullNameCofilin-1
TaxID9606
Evidenceevidence at protein level
Length166
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesCFL1

GO terms

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GOName
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0007010 cytoskeleton organization
GO:0007266 Rho protein signal transduction
GO:0009615 response to virus
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016032 viral process
GO:0016363 nuclear matrix
GO:0022604 regulation of cell morphogenesis
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030042 actin filament depolymerization
GO:0030043 actin filament fragmentation
GO:0031258 lamellipodium membrane
GO:0031982 vesicle
GO:0032587 ruffle membrane
GO:0035722 interleukin-12-mediated signaling pathway
GO:0040019 positive regulation of embryonic development
GO:0043066 negative regulation of apoptotic process
GO:0044794 positive regulation by host of viral process
GO:0048870 cell motility
GO:0051014 actin filament severing
GO:0051015 actin filament binding
GO:0051293 establishment of spindle localization
GO:0061001 regulation of dendritic spine morphogenesis
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Nucleus matrix

Domains

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DomainNameCategoryType
IPR002108 Actin-depolymerising factor homology domainDomainDomain
IPR017904 ADF/CofilinFamilyFamily
IPR027234 Cofilin 1FamilyFamily
IPR029006 ADF-H/Gelsolin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04147 Dodecyldimethylamine N-oxideDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
COF1_HUMANMYCBP_HUMANBioGRID, HPRD, IntAct16169070 details
COF1_HUMANACTB_HUMANBioGRID, HPRD, IntAct16189514 25416956 29892012 31515488 32015554 32296183 details
COF1_HUMANACTG_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
COF1_HUMANATX1_HUMANBioGRID, HPRD, IntAct16713569 32814053 details
COF1_HUMANPLD1_HUMANMINT17853892 details
COF1_HUMANPLD2_HUMANMINT17853892 details
COF1_HUMANLIMK1_HUMANBioGRID, DIP, HPRD, MINT10436159 11340065 11418599 11925442 12963706 15220930 16278681 16456544 17500066 17853892 19424295 20133759 23082153 23093407 32015554 9655398 details
COF1_HUMANPSN1_HUMANBioGRID, IntAct21163940 details
COF1_HUMANCOF2_HUMANBioGRID, MINT21516116 25416956 details
COF1_HUMANSSH1_HUMANBioGRID, HPRD, MINT11832213 12684437 21525957 25100728 32015554 details
COF1_HUMANEGFR_HUMANBioGRID, IntAct20029029 24658140 31980649 details
COF1_HUMANTAB1_HUMANBioGRID, MINT21900206 details
COF1_HUMANMK06_HUMANBioGRID, MINT21900206 details
COF1_HUMANJIP2_HUMANBioGRID, MINT21900206 details
COF1_HUMANKS6A1_HUMANBioGRID, MINT21900206 details
COF1_HUMANESR1_HUMANBioGRID, MINT25640309 details
COF1_HUMANERBB4_HUMANBioGRID, IntAct24658140 31980649 details
COF1_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
COF1_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
COF1_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
COF1_HUMANERBB3_HUMANBioGRID, IntAct31980649 details
COF1_HUMANOPTN_HUMANIntAct32814053 details
COF1_HUMANHS105_HUMANBioGRID, HPRD14733918 details
COF1_HUMANACTS_HUMANBioGRID, HPRD10366597 11707283 11950878 21723825 details
COF1_HUMANLIMK2_HUMANBioGRID, HPRD10436159 10613909 11340065 11418599 23082153 9655398 details
COF1_HUMANSRC_HUMANBioGRID19802004 details
COF1_HUMANUCHL5_HUMANBioGRID21800051 details
COF1_HUMANRAD21_HUMANBioGRID22145905 details
COF1_HUMANA4_HUMANBioGRID21163940 details
COF1_HUMAN1433T_HUMANBioGRID15161933 details
COF1_HUMANWDR1_HUMANBioGRID, HPRD10366597 26344197 details
COF1_HUMANPTEN_HUMANBioGRID26561776 details
COF1_HUMANTRI15_HUMANBioGRID25450970 details
COF1_HUMANUBC12_HUMANBioGRID28581483 32015554 details
COF1_HUMANAT1A1_HUMANHPRD11139403 details
COF1_HUMANCLCN5_HUMANHPRD12904289 details
COF1_HUMAN1433Z_HUMANHPRD, IntAct, MINT12323073 12361576 15161933 details
COF1_HUMAN1433G_HUMANHPRD, MINT15598710 details
COF1_HUMANARRB1_HUMANBioGRID, IntAct, UniProt17500066 17620599 details
COF1_HUMANARRB2_HUMANBioGRID, IntAct, UniProt17500066 17620599 details
COF1_HUMANH2AX_HUMANBioGRID, IntAct20000738 details
COF1_HUMANCAP1_HUMANBioGRID, IntAct11950878 26186194 28514442 details
COF1_HUMANPP2AA_HUMANDIP20133759 details
COF1_HUMANHUNK_HUMANDIP20133759 details
COF1_HUMANACTC_HUMANBioGRID, HPRD, IntAct12207032 30021884 30890647 details
COF1_HUMANMYCB2_HUMANMINT21653829 details
COF1_HUMANTXD17_HUMANBioGRID14607843 details
COF1_HUMANROCK1_HUMANBioGRID10436159 details
COF1_HUMANTPIS_HUMANBioGRID, HPRD12359716 details
COF1_HUMANISG15_HUMANBioGRID16009940 16815975 details
COF1_HUMANITA4_HUMANBioGRID22623428 details
COF1_HUMANKPCZ_HUMANBioGRID23402259 29491746 details
COF1_HUMANU2AF2_HUMANBioGRID26641092 details
COF1_HUMANSOX2_HUMANBioGRID21280222 details
COF1_HUMANGLUT4_HUMANHPRD16396496 details
COF1_HUMANTESK1_HUMANHPRD11294912 11340065 11418599 9655398 details
COF1_HUMANTESK2_HUMANHPRD11340065 11418599 9655398 details
COF1_HUMANSSH2_HUMANHPRD11832213 details
COF1_HUMANSSH3_HUMANHPRD11832213 details
COF1_HUMANNRK_HUMANHPRD12837278 details
COF1_HUMANACTA_HUMANHPRD11707283 details