Entity Details

Primary name AT2B4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23634
EntryNameAT2B4_HUMAN
FullNamePlasma membrane calcium-transporting ATPase 4
TaxID9606
Evidenceevidence at protein level
Length1241
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesATP2B4

GO terms

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GOName
GO:0003407 neural retina development
GO:0005388 P-type calcium transporter activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006874 cellular calcium ion homeostasis
GO:0007283 spermatogenesis
GO:0010629 negative regulation of gene expression
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0014832 urinary bladder smooth muscle contraction
GO:0015085 calcium ion transmembrane transporter activity
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016525 negative regulation of angiogenesis
GO:0017080 sodium channel regulator activity
GO:0019829 ATPase-coupled cation transmembrane transporter activity
GO:0019901 protein kinase binding
GO:0021766 hippocampus development
GO:0030018 Z disc
GO:0030165 PDZ domain binding
GO:0030315 T-tubule
GO:0030317 flagellated sperm motility
GO:0030346 protein phosphatase 2B binding
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034220 ion transmembrane transport
GO:0036126 sperm flagellum
GO:0036487 nitric-oxide synthase inhibitor activity
GO:0043005 neuron projection
GO:0043231 intracellular membrane-bounded organelle
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045121 membrane raft
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
GO:0050998 nitric-oxide synthase binding
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051599 response to hydrostatic pressure
GO:0070588 calcium ion transmembrane transport
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071872 cellular response to epinephrine stimulus
GO:0097110 scaffold protein binding
GO:0097228 sperm principal piece
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098703 calcium ion import across plasma membrane
GO:0098736 negative regulation of the force of heart contraction
GO:0098978 glutamatergic synapse
GO:0099059 integral component of presynaptic active zone membrane
GO:0140199 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
GO:0150104 transport across blood-brain barrier
GO:1900082 negative regulation of arginine catabolic process
GO:1901660 calcium ion export
GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation
GO:1902305 regulation of sodium ion transmembrane transport
GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress
GO:1903249 negative regulation of citrulline biosynthetic process
GO:1903779 regulation of cardiac conduction
GO:1905145 cellular response to acetylcholine
GO:2000481 positive regulation of cAMP-dependent protein kinase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR006408 P-type ATPase, subfamily IIBFamilyFamily
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminalDomainDomain
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01159 HalothaneDrugbanksmall molecule
DB01189 DesfluraneDrugbanksmall molecule