Entity Details

Primary name PPLA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26678
EntryNamePPLA_HUMAN
FullNameCardiac phospholamban
TaxID9606
Evidenceevidence at protein level
Length52
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPLN

GO terms

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GOName
GO:0002026 regulation of the force of heart contraction
GO:0004857 enzyme inhibitor activity
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0006816 calcium ion transport
GO:0007219 Notch signaling pathway
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0010043 response to zinc ion
GO:0010459 negative regulation of heart rate
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0031982 vesicle
GO:0032780 negative regulation of ATPase activity
GO:0032868 response to insulin
GO:0033017 sarcoplasmic reticulum membrane
GO:0033574 response to testosterone
GO:0042030 ATPase inhibitor activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043086 negative regulation of catalytic activity
GO:0048471 perinuclear region of cytoplasm
GO:0048738 cardiac muscle tissue development
GO:0051117 ATPase binding
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051924 regulation of calcium ion transport
GO:0051926 negative regulation of calcium ion transport
GO:0055119 relaxation of cardiac muscle
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086023 adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0086092 regulation of the force of heart contraction by cardiac conduction
GO:0090281 negative regulation of calcium ion import
GO:0090534 calcium ion-transporting ATPase complex
GO:1901020 negative regulation of calcium ion transmembrane transporter activity
GO:1901877 negative regulation of calcium ion binding
GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity
GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity
GO:1901897 regulation of relaxation of cardiac muscle
GO:1902081 negative regulation of calcium ion import into sarcoplasmic reticulum

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Membrane
Mitochondrion membrane
Sarcoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR005984 PhospholambanFamilyFamily

Diseases

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Disease IDSourceNameDescription
613874 OMIMCardiomyopathy, familial hypertrophic 18 (CMH18)A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. The disease is caused by variants affecting the gene represented in this entry.
609909 OMIMCardiomyopathy, dilated 1P (CMD1P)A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. The disease is caused by variants affecting the gene represented in this entry.

Interactions

67 interactions

InteractorPartnerSourcesPublicationsLink
PPLA_HUMANDMPK_HUMANBioGRID, HPRD, IntAct15598648 details
PPLA_HUMANDVL3_HUMANBioGRID, IntAct21988832 details
PPLA_HUMANPPLA_HUMANHPRD, UniProt16043693 details
PPLA_HUMANEDA_HUMANBioGRID, IntAct24722188 25416956 25910212 31515488 32296183 details
PPLA_HUMANTMM79_HUMANBioGRID, IntAct24722188 details
PPLA_HUMANLRAD1_HUMANBioGRID, IntAct24722188 32296183 details
PPLA_HUMANSTX2_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANMFF_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANSTX1A_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANBIK_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANT106C_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANFKBP8_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANGPX8_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANCPLX4_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANMGST3_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANTM45B_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANDHB13_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANMGST2_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANVA0E1_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANCXA8_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANKI2L3_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANSAR1A_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANMS4A7_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANTM86B_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANSACA1_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANPLPR1_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANIF3M_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANNPT2B_HUMANBioGRID, IntAct32296183 details
PPLA_HUMAN3HIDH_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANFNDC9_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANT179B_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANGP152_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANF209A_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANAR13B_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANZNT8_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANTM45A_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANRTN3_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANB2L13_HUMANBioGRID, IntAct25910212 32296183 details
PPLA_HUMANTMPS2_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANLSME2_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANCLC2D_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANUT2_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANSPAG4_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANASGR2_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANS39A2_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANCD53_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANSIT1_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANTM205_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANMUC1_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANCLD7_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANTM52B_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANG37L1_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANMFSD5_HUMANBioGRID, IntAct32296183 details
PPLA_HUMANCREB3_HUMANBioGRID, IntAct25910212 details
PPLA_HUMANCR3L1_HUMANBioGRID, IntAct25910212 details
PPLA_HUMANEMP3_HUMANMINT30614533 details
PPLA_HUMANAT2A2_HUMANBioGRID, HPRD10809745 11526231 11854448 12032137 31046837 details
PPLA_HUMANPPR3A_HUMANBioGRID, HPRD9845327 details
PPLA_HUMANSDC3_HUMANBioGRID32296183 details
PPLA_HUMANTMM31_HUMANBioGRID32296183 details
PPLA_HUMANSARCO_HUMANBioGRID, HPRD12032137 12692302 details
PPLA_HUMANAT2A1_HUMANBioGRID, HPRD10551848 11526231 12032137 details
PPLA_HUMANSQSTM_HUMANBioGRID26040000 details
PPLA_HUMANS10A1_HUMANHPRD12804600 details
PPLA_HUMANKAPCA_HUMANHPRD3759968 9468536 details