Entity Details

Primary name CALR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27797
EntryNameCALR_HUMAN
FullNameCalreticulin
TaxID9606
Evidenceevidence at protein level
Length417
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesCALR

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001669 acrosomal vesicle
GO:0001849 complement component C1q complex binding
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002502 peptide antigen assembly with MHC class I protein complex
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005178 integrin binding
GO:0005506 iron ion binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005790 smooth endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005844 polysome
GO:0005925 focal adhesion
GO:0006355 regulation of transcription, DNA-templated
GO:0006457 protein folding
GO:0006611 protein export from nucleus
GO:0006874 cellular calcium ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0007283 spermatogenesis
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0022417 protein maturation by protein folding
GO:0030133 transport vesicle
GO:0030246 carbohydrate binding
GO:0030670 phagocytic vesicle membrane
GO:0030866 cortical actin cytoskeleton organization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031625 ubiquitin protein ligase binding
GO:0032355 response to estradiol
GO:0033018 sarcoplasmic reticulum lumen
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033574 response to testosterone
GO:0034504 protein localization to nucleus
GO:0034975 protein folding in endoplasmic reticulum
GO:0036500 ATF6-mediated unfolded protein response
GO:0040020 regulation of meiotic nuclear division
GO:0042277 peptide binding
GO:0042493 response to drug
GO:0042562 hormone binding
GO:0042824 MHC class I peptide loading complex
GO:0042921 glucocorticoid receptor signaling pathway
GO:0042981 regulation of apoptotic process
GO:0044183 protein folding chaperone
GO:0044322 endoplasmic reticulum quality control compartment
GO:0045665 negative regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0050681 androgen receptor binding
GO:0050766 positive regulation of phagocytosis
GO:0050821 protein stabilization
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0051208 sequestering of calcium ion
GO:0055007 cardiac muscle cell differentiation
GO:0060473 cortical granule
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071285 cellular response to lithium ion
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:0071682 endocytic vesicle lumen
GO:0090398 cellular senescence
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901164 negative regulation of trophoblast cell migration
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
GO:2000510 positive regulation of dendritic cell chemotaxis

Subcellular Location

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Subcellular Location
Cell surface
Cytolytic granule
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum lumen
Sarcoplasmic reticulum lumen
Secreted

Domains

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DomainNameCategoryType
IPR001580 Calreticulin/calnexinFamilyFamily
IPR009033 Calreticulin/calnexin, P domain superfamilyFamilyHomologous superfamily
IPR009169 CalreticulinFamilyFamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR018124 Calreticulin/calnexin, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB00031 TenecteplaseDrugbankbiotech
DB01065 MelatoninDrugbanksmall molecule
DB06245 LanoteplaseDrugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB13949 Ferric cationDrugbanksmall molecule
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule
DB14520 Tetraferric tricitrate decahydrateDrugbanksmall molecule

Interactions

130 interactions

InteractorPartnerSourcesPublicationsLink
CALR_HUMANPDIA3_HUMANBioGRID, HPRD, IntAct, MINT10436013 11823531 12052826 24981860 26344197 30021884 details
CALR_HUMANMTR1A_HUMANBioGRID, HPRD, IntAct, MINT17215244 26514267 28298427 details
CALR_HUMANA4_HUMANBioGRID, HPRD, IntAct11378243 15896298 25241761 32814053 details
CALR_HUMANGBRAP_HUMANIntAct19154346 20562859 details
CALR_HUMANLRIF1_HUMANBioGRID, MINT21900206 details
CALR_HUMANSNF5_HUMANBioGRID, IntAct, MINT21900206 30108113 details
CALR_HUMANMK06_HUMANBioGRID, MINT21900206 details
CALR_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
CALR_HUMANTAF1B_HUMANBioGRID, IntAct32296183 details
CALR_HUMANGSC2_HUMANBioGRID, IntAct32296183 details
CALR_HUMANSGTB_HUMANBioGRID, IntAct32296183 details
CALR_HUMANPSMD2_HUMANIntAct32814053 details
CALR_HUMANPRS6B_HUMANIntAct32814053 details
CALR_HUMANPPE1_HUMANIntAct32814053 details
CALR_HUMANCNOT3_HUMANIntAct32814053 details
CALR_HUMANMAGA2_HUMANIntAct32814053 details
CALR_HUMANEPCAM_HUMANIntAct32814053 details
CALR_HUMANLEG8_HUMANIntAct32814053 details
CALR_HUMANLEG1_HUMANIntAct32814053 details
CALR_HUMANNKG2A_HUMANIntAct32814053 details
CALR_HUMANIDHC_HUMANIntAct32814053 details
CALR_HUMAN3BHS1_HUMANIntAct32814053 details
CALR_HUMANDRB3_HUMANIntAct32814053 details
CALR_HUMANGNAO_HUMANIntAct32814053 details
CALR_HUMANCXA5_HUMANIntAct32814053 details
CALR_HUMANFUT2_HUMANIntAct32814053 details
CALR_HUMANDNSL1_HUMANIntAct32814053 details
CALR_HUMANHUWE1_HUMANBioGRID, IntAct25147182 32814053 details
CALR_HUMANRASF2_HUMANIntAct32814053 details
CALR_HUMANM2OM_HUMANIntAct32814053 details
CALR_HUMANTSP3_HUMANIntAct32814053 details
CALR_HUMANT23O_HUMANIntAct32814053 details
CALR_HUMANRAP1B_HUMANIntAct32814053 details
CALR_HUMANEGFL8_HUMANIntAct32814053 details
CALR_HUMANTHAP7_HUMANIntAct32814053 details
CALR_HUMANSP6_HUMANIntAct32814053 details
CALR_HUMANCREL2_HUMANIntAct32814053 details
CALR_HUMANARG28_HUMANIntAct32814053 details
CALR_HUMANTNMD_HUMANIntAct32814053 details
CALR_HUMANMAVS_HUMANIntAct32814053 details
CALR_HUMANISY1_HUMANIntAct32814053 details
CALR_HUMANMYNN_HUMANIntAct32814053 details
CALR_HUMANEVA1B_HUMANIntAct32814053 details
CALR_HUMANTSAP1_HUMANIntAct32814053 details
CALR_HUMANTMX3_HUMANIntAct32814053 details
CALR_HUMANPIAS4_HUMANIntAct32814053 details
CALR_HUMANFAH2A_HUMANIntAct32814053 details
CALR_HUMANSERC_HUMANIntAct32814053 details
CALR_HUMANPYGO1_HUMANIntAct32814053 details
CALR_HUMANTPGS2_HUMANIntAct32814053 details
CALR_HUMANPOC1A_HUMANIntAct32814053 details
CALR_HUMANCMTA2_HUMANIntAct32814053 details
CALR_HUMANTPX2_HUMANIntAct32814053 details
CALR_HUMANRAB31_HUMANIntAct32814053 details
CALR_HUMANNEK6_HUMANIntAct32814053 details
CALR_HUMANRBM5_HUMANIntAct32814053 details
CALR_HUMANMFI_HUMANIntAct32814053 details
CALR_HUMANPBIR3_HUMANIntAct32814053 details
CALR_HUMANSPT17_HUMANIntAct32814053 details
CALR_HUMANCA216_HUMANIntAct32814053 details
CALR_HUMANNXPE1_HUMANIntAct32814053 details
CALR_HUMANRAB3C_HUMANIntAct32814053 details
CALR_HUMANNLRP3_HUMANIntAct32814053 details
CALR_HUMANSPF45_HUMANIntAct32814053 details
CALR_HUMANZHX1R_HUMANIntAct32814053 details
CALR_HUMANNF2IP_HUMANIntAct32814053 details
CALR_HUMANDRC7_HUMANIntAct32814053 details
CALR_HUMANPRAM_HUMANIntAct32814053 details
CALR_HUMANSPRE2_HUMANIntAct32814053 details
CALR_HUMANTBB5_HUMANIntAct32814053 details
CALR_HUMANLEG1H_HUMANIntAct32814053 details
CALR_HUMANMBPHL_HUMANIntAct32814053 details
CALR_HUMANMMAB_HUMANIntAct32814053 details
CALR_HUMANUBP12_HUMANIntAct32814053 details
CALR_HUMANTPA_HUMANBioGRID, HPRD9359841 details
CALR_HUMANMBL2_HUMANBioGRID, HPRD8062452 details
CALR_HUMANPERF_HUMANBioGRID, HPRD9671507 details
CALR_HUMANANDR_HUMANBioGRID, HPRD8107809 details
CALR_HUMANGCR_HUMANBioGRID, HPRD8107808 9089287 details
CALR_HUMANTRFE_HUMANBioGRID, HPRD9312001 details
CALR_HUMANSC6A4_HUMANBioGRID, HPRD10364189 details
CALR_HUMANNKX21_HUMANBioGRID, HPRD9988700 details
CALR_HUMANGTR1_HUMANBioGRID, HPRD8662691 details
CALR_HUMANHLAE_HUMANBioGRID15383281 9427624 details
CALR_HUMANHLAA_HUMANBioGRID15383281 details
CALR_HUMANCALR_HUMANBioGRID, HPRD15383281 8910335 9036970 details
CALR_HUMANRENT2_HUMANBioGRID15231747 details
CALR_HUMANUBE3A_HUMANBioGRID26506232 details
CALR_HUMANRO52_HUMANBioGRID8666824 details
CALR_HUMANSHPS1_HUMANBioGRID19299420 details
CALR_HUMANPTN11_HUMANBioGRID19299420 details
CALR_HUMANSQSTM_HUMANBioGRID31375263 details
CALR_HUMANOGT1_HUMANBioGRID32994395 details
CALR_HUMANPAK2_HUMANIntAct17353931 details
CALR_HUMANTR10D_HUMANIntAct17353931 details
CALR_HUMANEIF1B_HUMANIntAct17353931 details
CALR_HUMANTRAF6_HUMANIntAct17353931 details
CALR_HUMAN1433Z_HUMANMINT15161933 details
CALR_HUMANTAP1_HUMANBioGRID, IntAct11823531 17055437 details
CALR_HUMANH2AX_HUMANBioGRID, IntAct16522924 20000738 details
CALR_HUMANMP2K1_HUMANIntAct22752157 details
CALR_HUMANKSR1_HUMANIntAct22752157 details
CALR_HUMANPDIA2_HUMANHPRD, MINT23167757 8537405 details
CALR_HUMANB2MG_HUMANBioGRID, HPRD, IntAct25241761 8769474 details
CALR_HUMANFA8_HUMANBioGRID, HPRD, IntAct25241761 9525969 details
CALR_HUMANTECT2_HUMANBioGRID, IntAct27173435 unassigned1312 details
CALR_HUMANTPSN_HUMANBioGRID, HPRD, IntAct11823531 30021884 8769474 details
CALR_HUMANLRP1_HUMANBioGRID, HPRD12821648 14980518 details
CALR_HUMANCALX_HUMANBioGRID10436013 31536960 details
CALR_HUMANFIBB_HUMANBioGRID, HPRD7592883 details
CALR_HUMANCD1D_HUMANBioGRID, HPRD12239218 details
CALR_HUMANAPOB_HUMANBioGRID, HPRD10513896 12397072 9694898 details
CALR_HUMANVWF_HUMANBioGRID, HPRD10887119 details
CALR_HUMANFA5_HUMANBioGRID, HPRD9525969 details
CALR_HUMANKCNH2_HUMANBioGRID22242185 details
CALR_HUMANLIPL_HUMANBioGRID, HPRD12740382 details
CALR_HUMANITA3_HUMANBioGRID8006073 details
CALR_HUMANS27A2_HUMANBioGRID10198260 details
CALR_HUMANTSHR_HUMANBioGRID, HPRD12383251 details
CALR_HUMANMYPR_HUMANBioGRID, HPRD12196561 details
CALR_HUMANU2AF2_HUMANBioGRID26641092 details
CALR_HUMANHYPK_HUMANBioGRID23272104 details
CALR_HUMANHLAB_HUMANBioGRID11823531 details
CALR_HUMANFBN1_HUMANHPRD10547375 details
CALR_HUMANHLAC_HUMANHPRD8769474 details
CALR_HUMANTSP1_HUMANHPRD12147682 details
CALR_HUMANITAV_HUMANHPRD12196561 details
CALR_HUMANITA2B_HUMANHPRD14985176 details
CALR_HUMANSREC_HUMANHPRD15371419 details
CALR_HUMANSUMO4_HUMANHPRD16236267 details