Entity Details

Primary name 5HT2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28223
EntryName5HT2A_HUMAN
FullName5-hydroxytryptamine receptor 2A
TaxID9606
Evidenceevidence at protein level
Length471
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesHTR2A

GO terms

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GOName
GO:0001587 Gq/11-coupled serotonin receptor activity
GO:0001618 virus receptor activity
GO:0001659 temperature homeostasis
GO:0001965 G-protein alpha-subunit binding
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007208 phospholipase C-activating serotonin receptor signaling pathway
GO:0007210 serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007568 aging
GO:0007613 memory
GO:0008219 cell death
GO:0008284 positive regulation of cell population proliferation
GO:0010513 positive regulation of phosphatidylinositol biosynthetic process
GO:0014059 regulation of dopamine secretion
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014824 artery smooth muscle contraction
GO:0014832 urinary bladder smooth muscle contraction
GO:0030424 axon
GO:0030425 dendrite
GO:0030431 sleep
GO:0030594 neurotransmitter receptor activity
GO:0031410 cytoplasmic vesicle
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0043267 negative regulation of potassium ion transport
GO:0043406 positive regulation of MAP kinase activity
GO:0044380 protein localization to cytoskeleton
GO:0044877 protein-containing complex binding
GO:0045600 positive regulation of fat cell differentiation
GO:0045821 positive regulation of glycolytic process
GO:0045907 positive regulation of vasoconstriction
GO:0048148 behavioral response to cocaine
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051378 serotonin binding
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070852 cell body fiber
GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
GO:0098664 G protein-coupled serotonin receptor signaling pathway
GO:0098666 G protein-coupled serotonin receptor complex
GO:0098978 glutamatergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasmic vesicle
Membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000455 5-Hydroxytryptamine 2A receptorFamilyFamily
IPR002231 5-hydroxytryptamine receptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00246 ZiprasidoneDrugbanksmall molecule
DB00247 MethysergideDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00315 ZolmitriptanDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00370 MirtazapineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00409 RemoxiprideDrugbanksmall molecule
DB00420 PromazineDrugbanksmall molecule
DB00434 CyproheptadineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00574 FenfluramineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00604 CisaprideDrugbanksmall molecule
DB00623 FluphenazineDrugbanksmall molecule
DB00656 TrazodoneDrugbanksmall molecule
DB00679 ThioridazineDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00751 EpinastineDrugbanksmall molecule
DB00777 PropiomazineDrugbanksmall molecule
DB00805 MinaprineDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00875 FlupentixolDrugbanksmall molecule
DB00924 CyclobenzaprineDrugbanksmall molecule
DB00933 MesoridazineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01079 TegaserodDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01242 ClomipramineDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01442 MMDADrugbanksmall molecule
DB01454 MidomafetamineDrugbanksmall molecule
DB01488 DimethyltryptamineDrugbanksmall molecule
DB01537 4-Bromo-2,5-dimethoxyphenethylamineDrugbanksmall molecule
DB01614 AcepromazineDrugbanksmall molecule
DB01618 MolindoneDrugbanksmall molecule
DB01621 PipotiazineDrugbanksmall molecule
DB01622 ThioproperazineDrugbanksmall molecule
DB01623 ThiothixeneDrugbanksmall molecule
DB01624 ZuclopenthixolDrugbanksmall molecule
DB04599 AniracetamDrugbanksmall molecule
DB04842 FluspirileneDrugbanksmall molecule
DB04908 FlibanserinDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB05079 HY10275Drugbanksmall molecule
DB05227 APD791Drugbanksmall molecule
DB05316 PimavanserinDrugbanksmall molecule
DB05492 Epicept NP-1Drugbanksmall molecule
DB05687 BL-1020Drugbanksmall molecule
DB06016 CariprazineDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06109 YKP-1358Drugbanksmall molecule
DB06144 SertindoleDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06229 OcaperidoneDrugbanksmall molecule
DB06288 AmisulprideDrugbanksmall molecule
DB06446 DotarizineDrugbanksmall molecule
DB06512 DeramciclaneDrugbanksmall molecule
DB06678 EsmirtazapineDrugbanksmall molecule
DB08810 CinitaprideDrugbanksmall molecule
DB08815 LurasidoneDrugbanksmall molecule
DB08839 SerotoninDrugbanksmall molecule
DB08922 PerospironeDrugbanksmall molecule
DB08927 AmperozideDrugbanksmall molecule
DB09016 ButriptylineDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09128 BrexpiprazoleDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09195 LorpiprazoleDrugbanksmall molecule
DB09223 BlonanserinDrugbanksmall molecule
DB09225 ZotepineDrugbanksmall molecule
DB09286 PipamperoneDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB12163 SarpogrelateDrugbanksmall molecule
DB12177 EplivanserinDrugbanksmall molecule
DB12465 KetanserinDrugbanksmall molecule
DB12555 NelotanserinDrugbanksmall molecule
DB12693 RitanserinDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB13940 2,5-Dimethoxy-4-ethylthioamphetamineDrugbanksmall molecule
DB13948 N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamineDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14010 5-methoxy-N,N-dimethyltryptamineDrugbanksmall molecule
DB14011 NabiximolsDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
5HT2A_HUMANMPDZ_HUMANMINT11150294 details
5HT2A_HUMANKS6A3_HUMANDIP, HPRD16537434 details
5HT2A_HUMANPPP5_HUMANDIP, HPRD16537434 details
5HT2A_HUMANPON2_HUMANDIP, HPRD16537434 details
5HT2A_HUMANANS1B_HUMANDIP, HPRD16537434 details
5HT2A_HUMANGLNA_HUMANDIP, HPRD16537434 details
5HT2A_HUMANMAP1A_HUMANDIP, HPRD16537434 details
5HT2A_HUMANEIF3F_HUMANDIP, HPRD16537434 details
5HT2A_HUMANNDK3_HUMANDIP, HPRD16537434 details
5HT2A_HUMANNTRK3_HUMANDIP, HPRD16537434 details
5HT2A_HUMANNDUBA_HUMANDIP, HPRD16537434 details
5HT2A_HUMANRM28_HUMANDIP, HPRD16537434 details
5HT2A_HUMANGRM2_HUMANDIP18297054 details
5HT2A_HUMANARRB2_HUMANDIP26158621 details
5HT2A_HUMANCNR1_HUMANDIP26158621 details
5HT2A_HUMAN5HT2C_HUMANIntAct28258217 30157263 details
5HT2A_HUMAN5HT2A_HUMANIntAct19279328 28258217 30157263 details
5HT2A_HUMAN5HT2B_HUMANIntAct28258217 details
5HT2A_HUMAN5HT1A_HUMANIntAct28920103 details
5HT2A_HUMANOXYR_HUMANIntAct31038917 details
5HT2A_HUMANDRD2_HUMANIntAct20888323 details
5HT2A_HUMANARF6_HUMANBioGRID14573774 16545942 details
5HT2A_HUMANARF1_HUMANBioGRID14573774 16545942 details
5HT2A_HUMANDLG1_HUMANBioGRID24989932 details
5HT2A_HUMANWRIP1_HUMANIntAct26617989 details
5HT2A_HUMANDLG4_HUMANBioGRID, HPRD12682061 details
5HT2A_HUMANJAK2_HUMANBioGRID, HPRD9169451 details
5HT2A_HUMANCBL_HUMANBioGRID21464131 details
5HT2A_HUMANGNAQ_HUMANHPRD11916537 details
5HT2A_HUMANGNAI1_HUMANHPRD11916537 details
5HT2A_HUMANGNA11_HUMANHPRD11916537 details