Entity Details

Primary name NOS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29475
EntryNameNOS1_HUMAN
FullNameNitric oxide synthase, brain
TaxID9606
Evidenceevidence at protein level
Length1434
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesNOS1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001917 photoreceptor inner segment
GO:0002028 regulation of sodium ion transport
GO:0004517 nitric-oxide synthase activity
GO:0005516 calmodulin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006527 arginine catabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007263 nitric oxide mediated signal transduction
GO:0007520 myoblast fusion
GO:0009408 response to heat
GO:0009725 response to hormone
GO:0010181 FMN binding
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0012506 vesicle membrane
GO:0014069 postsynaptic density
GO:0016491 oxidoreductase activity
GO:0016529 sarcoplasmic reticulum
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0017080 sodium channel regulator activity
GO:0018119 peptidyl-cysteine S-nitrosylation
GO:0020037 heme binding
GO:0031284 positive regulation of guanylate cyclase activity
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033555 multicellular organismal response to stress
GO:0034617 tetrahydrobiopterin binding
GO:0034618 arginine binding
GO:0035066 positive regulation of histone acetylation
GO:0042136 neurotransmitter biosynthetic process
GO:0042311 vasodilation
GO:0042383 sarcolemma
GO:0042738 exogenous drug catabolic process
GO:0043197 dendritic spine
GO:0043267 negative regulation of potassium ion transport
GO:0044325 transmembrane transporter binding
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045454 cell redox homeostasis
GO:0045776 negative regulation of blood pressure
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046870 cadmium ion binding
GO:0048306 calcium-dependent protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0051346 negative regulation of hydrolase activity
GO:0051612 negative regulation of serotonin uptake
GO:0051926 negative regulation of calcium ion transport
GO:0055117 regulation of cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0071363 cellular response to growth factor stimulus
GO:0071944 cell periphery
GO:0097110 scaffold protein binding
GO:0098735 positive regulation of the force of heart contraction
GO:0098924 retrograde trans-synaptic signaling by nitric oxide
GO:1902307 positive regulation of sodium ion transmembrane transport
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR001094 Flavodoxin-likeDomainDomain
IPR001433 Oxidoreductase FAD/NAD(P)-bindingDomainDomain
IPR001478 PDZ domainDomainDomain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductaseDomainDomain
IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-bindingDomainDomain
IPR004030 Nitric oxide synthase, N-terminalDomainDomain
IPR008254 Flavodoxin/nitric oxide synthaseDomainDomain
IPR012144 Nitric-oxide synthase, eukaryoteFamilyFamily
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR029039 Flavoprotein-like superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036119 Nitric oxide synthase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00155 CitrullineDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01821 L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amideDrugbanksmall molecule
DB01942 Formic acidDrugbanksmall molecule
DB01997 3-Bromo-7-NitroindazoleDrugbanksmall molecule
DB02027 N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidineDrugbanksmall molecule
DB02044 N-[3-(aminomethyl)benzyl]acetamidineDrugbanksmall molecule
DB02077 L-N(omega)-nitroarginine-(4R)-amino-L-proline amideDrugbanksmall molecule
DB02143 1-hydroxy-2-isopropylguanidineDrugbanksmall molecule
DB02644 N-omega-propyl-L-arginineDrugbanksmall molecule
DB02727 2-butyl-1-hydroxyguanidineDrugbanksmall molecule
DB02991 S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]IsothioureaDrugbanksmall molecule
DB03144 N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineDrugbanksmall molecule
DB03147 Flavin adenine dinucleotideDrugbanksmall molecule
DB03247 Flavin mononucleotideDrugbanksmall molecule
DB03449 N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamideDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB03707 S-Ethyl-N-Phenyl-IsothioureaDrugbanksmall molecule
DB03710 [(1S)-4-(1-Aminobutylideneamino)-1-carboxybutyl]azaniumDrugbanksmall molecule
DB03892 5-N-Allyl-arginineDrugbanksmall molecule
DB04223 NitroarginineDrugbanksmall molecule
DB06096 NXN-188Drugbanksmall molecule
DB08018 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINEDrugbanksmall molecule
DB08019 N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamineDrugbanksmall molecule
DB09241 Methylene blueDrugbanksmall molecule

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
NOS1_HUMANVAC14_HUMANHPRD, MINT17161399 details
NOS1_HUMANZDH23_HUMANBioGRID, HPRD15105416 details
NOS1_HUMANRASD1_HUMANBioGRID, HPRD11086993 details
NOS1_HUMANSYN1_HUMANBioGRID11867766 details
NOS1_HUMANSNTA1_HUMANBioGRID, HPRD10221915 11747091 9412493 details
NOS1_HUMANCAPON_HUMANBioGRID, HPRD9459447 details
NOS1_HUMANDLG4_HUMANBioGRID, HPRD10488080 8625413 9459447 details
NOS1_HUMANDLG2_HUMANBioGRID, HPRD8625413 8922396 details
NOS1_HUMANCHIP_HUMANBioGRID15466472 20729196 23109339 32591478 details
NOS1_HUMANKPCD1_HUMANBioGRID24740233 details
NOS1_HUMANNOS1_HUMANBioGRID8995432 details
NOS1_HUMANSOX2_HUMANBioGRID26607632 details
NOS1_HUMANDYL1_HUMANHPRD8864115 9808772 9837926 details
NOS1_HUMANNMDE1_HUMANDIP17360663 details
NOS1_HUMANBKRB2_HUMANBioGRID, HPRD10681501 details
NOS1_HUMANPTN6_HUMANBioGRID, HPRD11511520 details
NOS1_HUMANHSP74_HUMANBioGRID15466472 details
NOS1_HUMANDMD_HUMANBioGRID7545544 details
NOS1_HUMANAPRIO_HUMANBioGRID11032878 details
NOS1_HUMANPRIO_HUMANBioGRID11032878 details
NOS1_HUMANHS90A_HUMANHPRD11284722 9880522 details
NOS1_HUMANPFKAM_HUMANHPRD10187848 details
NOS1_HUMANAT2B4_HUMANHPRD11591728 details
NOS1_HUMANADA1A_HUMANHPRD12184796 details
NOS1_HUMANADA1D_HUMANHPRD12184796 details
NOS1_HUMANADA1B_HUMANHPRD12184796 details
NOS1_HUMANADRB1_HUMANHPRD12184796 details
NOS1_HUMANADRB2_HUMANHPRD12184796 details
NOS1_HUMANHMOX1_HUMANHPRD11849436 details
NOS1_HUMANKPCA_HUMANHPRD10400690 10874031 12630910 1375933 details
NOS1_HUMANARGI1_HUMANHPRD11849441 details
NOS1_HUMANCAV3_HUMANHPRD9353265 details
NOS1_HUMANKAPCA_HUMANHPRD10400690 10874031 12630910 1375933 details
NOS1_HUMANPTPRN_HUMANHPRD11043403 details
NOS1_HUMANCTBP1_HUMANHPRD11590170 details
NOS1_HUMANKCC1A_HUMANHPRD10400690 10874031 12630910 1375933 15251453 details
NOS1_HUMANKCC4_HUMANHPRD10400690 10874031 12630910 1375933 details
NOS1_HUMANDLGP2_HUMANHPRD10824095 details
NOS1_HUMANNOSIP_HUMANHPRD15548660 details