Entity Details

Primary name SC6A4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31645
EntryNameSC6A4_HUMAN
FullNameSodium-dependent serotonin transporter
TaxID9606
Evidenceevidence at protein level
Length630
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesSLC6A4

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005335 serotonin:sodium symporter activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006836 neurotransmitter transport
GO:0007584 response to nutrient
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0008504 monoamine transmembrane transporter activity
GO:0009636 response to toxic substance
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0012505 endomembrane system
GO:0014064 positive regulation of serotonin secretion
GO:0015844 monoamine transport
GO:0017075 syntaxin-1 binding
GO:0019811 cocaine binding
GO:0021941 negative regulation of cerebellar granule cell precursor proliferation
GO:0032227 negative regulation of synaptic transmission, dopaminergic
GO:0032355 response to estradiol
GO:0035176 social behavior
GO:0035725 sodium ion transmembrane transport
GO:0042136 neurotransmitter biosynthetic process
GO:0042310 vasoconstriction
GO:0042493 response to drug
GO:0042713 sperm ejaculation
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045665 negative regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0046621 negative regulation of organ growth
GO:0046872 metal ion binding
GO:0048854 brain morphogenesis
GO:0050998 nitric-oxide synthase binding
GO:0051015 actin filament binding
GO:0051378 serotonin binding
GO:0051610 serotonin uptake
GO:0071300 cellular response to retinoic acid
GO:0071321 cellular response to cGMP
GO:0090067 regulation of thalamus size
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0099154 serotonergic synapse

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Endomembrane system
Endosome membrane

Domains

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DomainNameCategoryType
IPR000175 Sodium:neurotransmitter symporterFamilyFamily
IPR013086 Sodium:neurotransmitter symporter, serotonin, N-terminalDomainDomain
IPR037272 Sodium:neurotransmitter symporter superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00176 FluvoxamineDrugbanksmall molecule
DB00182 AmphetamineDrugbanksmall molecule
DB00191 PhentermineDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00215 CitalopramDrugbanksmall molecule
DB00245 BenzatropineDrugbanksmall molecule
DB00285 VenlafaxineDrugbanksmall molecule
DB00289 AtomoxetineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00344 ProtriptylineDrugbanksmall molecule
DB00370 MirtazapineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00472 FluoxetineDrugbanksmall molecule
DB00476 DuloxetineDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00574 FenfluramineDrugbanksmall molecule
DB00579 MazindolDrugbanksmall molecule
DB00656 TrazodoneDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00721 ProcaineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00805 MinaprineDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00924 CyclobenzaprineDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01079 TegaserodDrugbanksmall molecule
DB01104 SertralineDrugbanksmall molecule
DB01105 SibutramineDrugbanksmall molecule
DB01114 ChlorpheniramineDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01191 DexfenfluramineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01242 ClomipramineDrugbanksmall molecule
DB01363 Ephedra sinica rootDrugbankbiotech
DB01442 MMDADrugbanksmall molecule
DB01454 MidomafetamineDrugbanksmall molecule
DB01472 4-MethoxyamphetamineDrugbanksmall molecule
DB01577 MetamfetamineDrugbanksmall molecule
DB04821 NomifensineDrugbanksmall molecule
DB04832 ZimelidineDrugbanksmall molecule
DB04836 AmineptineDrugbanksmall molecule
DB04889 BicifadineDrugbanksmall molecule
DB04896 MilnacipranDrugbanksmall molecule
DB05422 OPC-14523Drugbanksmall molecule
DB05688 CRx-119Drugbanksmall molecule
DB05964 AmitifadineDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06156 TesofensineDrugbanksmall molecule
DB06204 TapentadolDrugbanksmall molecule
DB06684 VilazodoneDrugbanksmall molecule
DB06700 DesvenlafaxineDrugbanksmall molecule
DB06701 DexmethylphenidateDrugbanksmall molecule
DB08839 SerotoninDrugbanksmall molecule
DB08918 LevomilnacipranDrugbanksmall molecule
DB09016 ButriptylineDrugbanksmall molecule
DB09068 VortioxetineDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09186 NisoxetineDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09195 LorpiprazoleDrugbanksmall molecule
DB09225 ZotepineDrugbanksmall molecule
DB12305 DasotralineDrugbanksmall molecule