Entity Details

Primary name AKT2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31751
EntryNameAKT2_HUMAN
FullNameRAC-beta serine/threonine-protein kinase
TaxID9606
Evidenceevidence at protein level
Length481
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesAKT2

GO terms

Show/Hide Table
GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0005978 glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006417 regulation of translation
GO:0006464 cellular protein modification process
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010907 positive regulation of glucose metabolic process
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0018105 peptidyl-serine phosphorylation
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0031340 positive regulation of vesicle fusion
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032287 peripheral nervous system myelin maintenance
GO:0032587 ruffle membrane
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045444 fat cell differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046872 metal ion binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0060644 mammary gland epithelial cell differentiation
GO:0065002 intracellular protein transmembrane transport
GO:0071486 cellular response to high light intensity
GO:0072659 protein localization to plasma membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:0090630 activation of GTPase activity
GO:0097473 retinal rod cell apoptotic process
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000147 positive regulation of cell motility

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm
Early endosome
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR034677 Protein Kinase B beta, catalytic domainDomainDomain
IPR039026 Protein Kinase B, pleckstrin homology domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB07812 N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamideDrugbanksmall molecule
DB07859 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINEDrugbanksmall molecule
DB07947 ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDEDrugbanksmall molecule
DB08073 (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEDrugbanksmall molecule

Interactions

68 interactions

InteractorPartnerSourcesPublicationsLink
AKT2_HUMANPRKDC_HUMANBioGRID15678105 16221682 details
AKT2_HUMANMTCP1_HUMANBioGRID, HPRD10983986 11707444 details
AKT2_HUMANGSK3B_HUMANBioGRID, HPRD, IntAct12434148 details
AKT2_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
AKT2_HUMANDP13A_HUMANBioGRID, HPRD10490823 17030088 details
AKT2_HUMANTCL1A_HUMANBioGRID, HPRD10983986 11707444 details
AKT2_HUMANCCL14_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANREL_HUMANBioGRID, IntAct32296183 details
AKT2_HUMANPKHO1_HUMANBioGRID17942896 details
AKT2_HUMANAP2C_HUMANIntAct24835590 details
AKT2_HUMANCASP3_HUMANMINT17544405 details
AKT2_HUMANOFUT1_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANTMED2_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANSTEA4_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANESR1_HUMANBioGRID, HPRD11139588 11432835 11507039 9528769 details
AKT2_HUMANHS90A_HUMANBioGRID, HPRD11988487 22939624 details
AKT2_HUMANMEOX2_HUMANBioGRID32296183 details
AKT2_HUMANABCG8_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANSH3R1_HUMANBioGRID, HPRD, IntAct14504284 17535800 32296183 details
AKT2_HUMANAPOB_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANLRRK2_HUMANIntAct24947832 details
AKT2_HUMANCLIP3_HUMANBioGRID19139280 details
AKT2_HUMANPI51C_HUMANBioGRID26149501 details
AKT2_HUMANSNAI1_HUMANBioGRID22158034 details
AKT2_HUMANSPR2A_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANRPA2_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANPDK1_HUMANIntAct27505672 details
AKT2_HUMANUCHL1_HUMANBioGRID28636190 details
AKT2_HUMANA4_HUMANBioGRID21832049 details
AKT2_HUMANBIEA_HUMANBioGRID27166089 details
AKT2_HUMANAPOA1_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANTTC3_HUMANBioGRID, UniProt20059950 details
AKT2_HUMANSNX27_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANNAMPT_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANVHL_HUMANBioGRID27563096 details
AKT2_HUMANVINEX_HUMANBioGRID, IntAct32296183 details
AKT2_HUMANH31_HUMANBioGRID22158034 details
AKT2_HUMANPLPL3_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANSRBS2_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANCDN1A_HUMANBioGRID16982699 details
AKT2_HUMANTCL1B_HUMANBioGRID, HPRD10983986 11707444 details
AKT2_HUMANTRIB3_HUMANBioGRID, HPRD12791994 30071535 details
AKT2_HUMANSKI_HUMANBioGRID19875456 details
AKT2_HUMANAKT1_HUMANBioGRID, HPRD, IntAct11278835 11445557 11546794 12149249 12176337 14500673 28514442 9736715 details
AKT2_HUMANFSHR_HUMANBioGRID, HPRD15070827 details
AKT2_HUMANEGLN1_HUMANBioGRID27563096 details
AKT2_HUMANHS90B_HUMANIntAct22939624 details
AKT2_HUMANAKT2_HUMANHPRD12434148 details
AKT2_HUMANPDPK1_HUMANBioGRID, HPRD12048203 27563096 9374542 9512493 details
AKT2_HUMANTSC2_HUMANHPRD12167664 details
AKT2_HUMANPFKAP_HUMANBioGRID29038421 details
AKT2_HUMANAKTS1_HUMANHPRD12524439 14973226 details
AKT2_HUMANGLUT4_HUMANHPRD11500317 details
AKT2_HUMANVIME_HUMANBioGRID, I2D20856200 details
AKT2_HUMANGBB1_HUMANBioGRID26895380 details
AKT2_HUMANSETB1_HUMANBioGRID, IntAct17577629 details
AKT2_HUMANCCNA2_HUMANDIP24670654 details
AKT2_HUMANKPCZ_HUMANBioGRID18353613 details
AKT2_HUMANFOXO4_HUMANHPRD11313479 details
AKT2_HUMANXIAP_HUMANHPRD14645242 details
AKT2_HUMANARRB2_HUMANDIP19122674 details
AKT2_HUMANPP2AA_HUMANBioGRID27563096 details
AKT2_HUMANRAB3D_HUMANHPRD11903042 details
AKT2_HUMANIKKA_HUMANHPRD12048203 details
AKT2_HUMANCUL1_HUMANBioGRID29103612 details
AKT2_HUMANFKBP5_HUMANBioGRID28363942 details
AKT2_HUMANCDC37_HUMANIntAct12176997 details
AKT2_HUMANWDR26_HUMANBioGRID26895380 details