Entity Details

Primary name CADH5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP33151
EntryNameCADH5_HUMAN
FullNameCadherin-5
TaxID9606
Evidenceevidence at protein level
Length784
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesCDH5

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0001932 regulation of protein phosphorylation
GO:0001944 vasculature development
GO:0001955 blood vessel maturation
GO:0005102 signaling receptor binding
GO:0005509 calcium ion binding
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005923 bicellular tight junction
GO:0006874 cellular calcium ion homeostasis
GO:0007043 cell-cell junction assembly
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007275 multicellular organism development
GO:0008013 beta-catenin binding
GO:0008285 negative regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0016342 catenin complex
GO:0019903 protein phosphatase binding
GO:0030054 cell junction
GO:0030335 positive regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0031115 negative regulation of microtubule polymerization
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031965 nuclear membrane
GO:0034332 adherens junction organization
GO:0035307 positive regulation of protein dephosphorylation
GO:0035633 maintenance of blood-brain barrier
GO:0043114 regulation of vascular permeability
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043534 blood vessel endothelial cell migration
GO:0044325 transmembrane transporter binding
GO:0044331 cell-cell adhesion mediated by cadherin
GO:0045296 cadherin binding
GO:0045766 positive regulation of angiogenesis
GO:0050728 negative regulation of inflammatory response
GO:0070051 fibrinogen binding
GO:0070700 BMP receptor binding
GO:0070830 bicellular tight junction assembly
GO:0098609 cell-cell adhesion
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:1902396 protein localization to bicellular tight junction
GO:1903142 positive regulation of establishment of endothelial barrier
GO:1990782 protein tyrosine kinase binding
GO:2000114 regulation of establishment of cell polarity
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000233 Cadherin, cytoplasmic domainDomainDomain
IPR002126 Cadherin-likeDomainDomain
IPR015919 Cadherin-like superfamilyFamilyHomologous superfamily
IPR020894 Cadherin conserved siteSiteConserved site
IPR027397 Catenin binding domain superfamilyFamilyHomologous superfamily
IPR030052 VE-cadherinFamilyFamily
IPR039808 CadherinFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00480 LenalidomideDrugbanksmall molecule
DB05685 FX06Drugbankbiotech

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
CADH5_HUMANSHC1_HUMANBioGRID, HPRD, MINT11950700 details
CADH5_HUMANCTNB1_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT, Molecular Connections12003790 12413882 17057644 18287330 18662404 20123964 20224040 22519731 22720799 23243000 28514442 9434630 details
CADH5_HUMANPKP4_HUMANBioGRID, HPRD, IntAct12426320 28514442 details
CADH5_HUMANSYWC_HUMANDIP20010843 details
CADH5_HUMANHTRA4_HUMANIntAct30638949 details
CADH5_HUMANPLAK_HUMANBioGRID, HPRD12003790 9434630 9739078 details
CADH5_HUMANPTPRB_HUMANBioGRID, HPRD12234928 details
CADH5_HUMANDESP_HUMANBioGRID, HPRD9739078 details
CADH5_HUMANFIBA_HUMANBioGRID, HPRD11900554 details
CADH5_HUMANEGFR_HUMANBioGRID24658140 25402006 details
CADH5_HUMANVGFR2_HUMANBioGRID, HPRD, MINT, Molecular Connections10428027 11950700 18662404 25657827 details
CADH5_HUMANPARD3_HUMANMINT17057644 details
CADH5_HUMANCTNA1_HUMANBioGRID, HPRD, IntAct, MINT12003790 17057644 28514442 9434630 details
CADH5_HUMANPAR6A_HUMANHPRD, MINT17057644 details
CADH5_HUMANPAR6G_HUMANMINT17057644 details
CADH5_HUMANSRC_HUMANHPRD, MINT16027153 16909109 details
CADH5_HUMANCNBP1_HUMANbhf-ucl18287330 details
CADH5_HUMANCTND1_HUMANBioGRID, HPRD, IntAct11855855 28514442 9378757 details
CADH5_HUMANP2RX4_HUMANBioGRID, HPRD12088286 details
CADH5_HUMANPTN11_HUMANBioGRID, HPRD10681592 details
CADH5_HUMANVIME_HUMANBioGRID, HPRD12003790 details
CADH5_HUMANFAK1_HUMANBioGRID22720799 details
CADH5_HUMANBMPR2_HUMANBioGRID26598555 details
CADH5_HUMANP2RY2_HUMANBioGRID25657827 details
CADH5_HUMANVINC_HUMANBioGRID26923917 details
CADH5_HUMANKPCA_HUMANBioGRID22519731 details
CADH5_HUMANSMG1_HUMANHPRD10428027 details
CADH5_HUMANP2RX6_HUMANHPRD12088286 details
CADH5_HUMANEPHA2_HUMANHPRD16481735 details
CADH5_HUMANCSK_HUMANHPRD15861137 details
CADH5_HUMANPAR3_HUMANHPRD17057644 details