Entity Details

Primary name CRFR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP34998
EntryNameCRFR1_HUMAN
FullNameCorticotropin-releasing factor receptor 1
TaxID9606
Evidenceevidence at protein level
Length444
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007565 female pregnancy
GO:0007567 parturition
GO:0008528 G protein-coupled peptide receptor activity
GO:0010578 regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway
GO:0015056 corticotrophin-releasing factor receptor activity
GO:0016021 integral component of membrane
GO:0017046 peptide hormone binding
GO:0031226 intrinsic component of plasma membrane
GO:0043005 neuron projection
GO:0043404 corticotropin-releasing hormone receptor activity
GO:0051424 corticotropin-releasing hormone binding
GO:0051458 corticotropin secretion
GO:0071376 cellular response to corticotropin-releasing hormone stimulus
GO:1901386 negative regulation of voltage-gated calcium channel activity
GO:2000852 regulation of corticosterone secretion

Subcellular Location

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Subcellular Location
Cell membrane
Endosome

Domains

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DomainNameCategoryType
IPR000832 GPCR, family 2, secretin-likeFamilyFamily
IPR001879 GPCR, family 2, extracellular hormone receptor domainDomainDomain
IPR003051 GPCR, family 2, corticotropin releasing factor receptorFamilyFamily
IPR003052 GPCR, family 2, corticotropin releasing factor receptor, type 1FamilyFamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR017983 GPCR, family 2, secretin-like, conserved siteSiteConserved site
IPR036445 GPCR family 2, extracellular hormone receptor domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09067 Corticorelin ovine triflutateDrugbanksmall molecule