Entity Details

Primary name ADA1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35348
EntryNameADA1A_HUMAN
FullNameAlpha-1A adrenergic receptor
TaxID9606
Evidenceevidence at protein level
Length466
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesADRA1A

GO terms

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GOName
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0004930 G protein-coupled receptor activity
GO:0004937 alpha1-adrenergic receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006915 apoptotic process
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007512 adult heart development
GO:0007568 aging
GO:0008285 negative regulation of cell population proliferation
GO:0009725 response to hormone
GO:0010507 negative regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031965 nuclear membrane
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042493 response to drug
GO:0043231 intracellular membrane-bounded organelle
GO:0043410 positive regulation of MAPK cascade
GO:0045760 positive regulation of action potential
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0046982 protein heterodimerization activity
GO:0060073 micturition
GO:0060402 calcium ion transport into cytosol
GO:0060452 positive regulation of cardiac muscle contraction
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090037 positive regulation of protein kinase C signaling
GO:0097195 pilomotor reflex
GO:0098691 dopaminergic synapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0150099 neuron-glial cell signaling
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane
Nucleus membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001004 Alpha 1A adrenoceptorFamilyFamily
IPR002233 Adrenoceptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00182 AmphetamineDrugbanksmall molecule
DB00211 MidodrineDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00268 RopiniroleDrugbanksmall molecule
DB00298 DapiprazoleDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00346 AlfuzosinDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00370 MirtazapineDrugbanksmall molecule
DB00388 PhenylephrineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00420 PromazineDrugbanksmall molecule
DB00433 ProchlorperazineDrugbanksmall molecule
DB00449 DipivefrinDrugbanksmall molecule
DB00450 DroperidolDrugbanksmall molecule
DB00457 PrazosinDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00490 BuspironeDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00575 ClonidineDrugbanksmall molecule
DB00590 DoxazosinDrugbanksmall molecule
DB00598 LabetalolDrugbanksmall molecule
DB00610 MetaraminolDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00656 TrazodoneDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00668 EpinephrineDrugbanksmall molecule
DB00679 ThioridazineDrugbanksmall molecule
DB00692 PhentolamineDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00697 TizanidineDrugbanksmall molecule
DB00699 NicergolineDrugbanksmall molecule
DB00706 TamsulosinDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00723 MethoxamineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00751 EpinastineDrugbanksmall molecule
DB00777 PropiomazineDrugbanksmall molecule
DB00797 TolazolineDrugbanksmall molecule
DB00800 FenoldopamDrugbanksmall molecule
DB00831 TrifluoperazineDrugbanksmall molecule
DB00841 DobutamineDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB00865 BenzphetamineDrugbanksmall molecule
DB00875 FlupentixolDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00925 PhenoxybenzamineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00935 OxymetazolineDrugbanksmall molecule
DB00964 ApraclonidineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01162 TerazosinDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01253 ErgometrineDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01295 BevantololDrugbanksmall molecule
DB01364 EphedrineDrugbanksmall molecule
DB01365 MephentermineDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01472 4-MethoxyamphetamineDrugbanksmall molecule
DB01576 DextroamphetamineDrugbanksmall molecule
DB01579 PhendimetrazineDrugbanksmall molecule
DB01614 AcepromazineDrugbanksmall molecule
DB01622 ThioproperazineDrugbanksmall molecule
DB01624 ZuclopenthixolDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB04948 LofexidineDrugbanksmall molecule
DB05469 R450Drugbanksmall molecule
DB05492 Epicept NP-1Drugbanksmall molecule
DB06144 SertindoleDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06207 SilodosinDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06229 OcaperidoneDrugbanksmall molecule
DB06262 DroxidopaDrugbanksmall molecule
DB06694 XylometazolineDrugbanksmall molecule
DB06706 IsomethepteneDrugbanksmall molecule
DB06711 NaphazolineDrugbanksmall molecule
DB06764 TetryzolineDrugbanksmall molecule
DB08922 PerospironeDrugbanksmall molecule
DB08950 IndoraminDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09195 LorpiprazoleDrugbanksmall molecule
DB09202 CirazolineDrugbanksmall molecule
DB09203 SynephrineDrugbanksmall molecule
DB09204 ArotinololDrugbanksmall molecule
DB09205 MoxisylyteDrugbanksmall molecule
DB09229 AranidipineDrugbanksmall molecule
DB09239 NiguldipineDrugbanksmall molecule
DB09286 PipamperoneDrugbanksmall molecule
DB11124 RacepinephrineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB11278 DL-MethylephedrineDrugbanksmall molecule
DB11577 Indigotindisulfonic acidDrugbanksmall molecule
DB12278 PropiverineDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule

Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
ADA1A_HUMANBMP1_HUMANHPRD, IntAct15525470 details
ADA1A_HUMANABR_HUMANHPRD, IntAct15525470 details
ADA1A_HUMANFLNC_HUMANHPRD, IntAct15525470 details
ADA1A_HUMANRENR_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANCD81_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANTM234_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANFA50B_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANF241B_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANGDE1_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANGPR37_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANAGRA3_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANHHATL_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANKLH22_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANK2013_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANTBC20_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANMBOA7_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANANO8_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANTPC2_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANSGCB_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANSCN1B_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANNTNG2_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANCGT_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANUBR4_HUMANBioGRID, MINT28298427 details
ADA1A_HUMANCREL1_HUMANIntAct20508391 details
ADA1A_HUMANADA1A_HUMANBioGRID, IntAct12888550 14645668 details
ADA1A_HUMANADA1B_HUMANBioGRID, HPRD, IntAct12888550 14645668 15525470 details
ADA1A_HUMANADA1D_HUMANHPRD15525470 details
ADA1A_HUMANCLH1_HUMANIntAct23460120 details
ADA1A_HUMANCLCA_HUMANIntAct23460120 details
ADA1A_HUMANCLCB_HUMANIntAct23460120 details
ADA1A_HUMANACKR3_HUMANIntAct28862946 details
ADA1A_HUMANCXCR4_HUMANIntAct25775528 27331810 28862946 details
ADA1A_HUMANRGS2_HUMANHPRD15917235 details
ADA1A_HUMANCXCR2_HUMANHPRD15946947 details
ADA1A_HUMANCXCR1_HUMANHPRD15946947 details
ADA1A_HUMANNOS1_HUMANHPRD12184796 details
ADA1A_HUMANNEB2_HUMANHPRD11154706 details