Entity Details

Primary name ACTN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35609
EntryNameACTN2_HUMAN
FullNameAlpha-actinin-2
TaxID9606
Evidenceevidence at protein level
Length894
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesACTN2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0002576 platelet degranulation
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005925 focal adhesion
GO:0007155 cell adhesion
GO:0008092 cytoskeletal protein binding
GO:0008307 structural constituent of muscle
GO:0019904 protein domain specific binding
GO:0030018 Z disc
GO:0030035 microspike assembly
GO:0030049 muscle filament sliding
GO:0030175 filopodium
GO:0030274 LIM domain binding
GO:0030374 nuclear receptor coactivator activity
GO:0030864 cortical actin cytoskeleton
GO:0031093 platelet alpha granule lumen
GO:0031143 pseudopodium
GO:0031432 titin binding
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043267 negative regulation of potassium ion transport
GO:0043268 positive regulation of potassium ion transport
GO:0044325 transmembrane transporter binding
GO:0045214 sarcomere organization
GO:0048041 focal adhesion assembly
GO:0051015 actin filament binding
GO:0051373 FATZ binding
GO:0051695 actin filament uncapping
GO:0055013 cardiac muscle cell development
GO:0070062 extracellular exosome
GO:0070080 titin Z domain binding
GO:0072659 protein localization to plasma membrane
GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway
GO:0098839 postsynaptic density membrane
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1901018 positive regulation of potassium ion transmembrane transporter activity
GO:2000009 negative regulation of protein localization to cell surface
GO:2000310 regulation of NMDA receptor activity
GO:2001137 positive regulation of endocytic recycling
GO:2001259 positive regulation of cation channel activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014837 EF-hand, Ca insensitiveDomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

126 interactions

InteractorPartnerSourcesPublicationsLink
ACTN2_HUMANKCNA4_HUMANHPRD, MINT11389904 details
ACTN2_HUMANKCNA5_HUMANbhf-ucl, BioGRID, HPRD, MINT10812072 11389904 12860415 details
ACTN2_HUMANLRP12_HUMANHPRD, IntAct12809483 details
ACTN2_HUMANMYOZ1_HUMANBioGRID, HPRD, MINT10984498 details
ACTN2_HUMANANGI_HUMANHPRD, IntAct15737636 details
ACTN2_HUMANTITIN_HUMANbhf-ucl, BioGRID, HPRD, IntAct, mbinfo, MINT11101506 11846417 16902413 23414517 9501083 details
ACTN2_HUMANACTN2_HUMANBioGRID, HPRD, IntAct, mbinfo11101506 25416956 25502805 31515488 9030526 9501083 details
ACTN2_HUMANDISC1_HUMANBioGRID, HPRD, IntAct12812986 31413325 details
ACTN2_HUMANATX2_HUMANBioGRID, HPRD, IntAct16713569 details
ACTN2_HUMANCOIL_HUMANBioGRID, HPRD, IntAct16713569 details
ACTN2_HUMANNOS3_HUMANBioGRID, IntAct21163940 details
ACTN2_HUMANATX7_HUMANBioGRID, IntAct21078624 details
ACTN2_HUMANRL35_HUMANBioGRID, IntAct21988832 details
ACTN2_HUMANZN446_HUMANBioGRID, IntAct21988832 details
ACTN2_HUMANDP13A_HUMANBioGRID, IntAct23414517 details
ACTN2_HUMANDYSF_HUMANBioGRID, IntAct23414517 details
ACTN2_HUMANMYOM2_HUMANBioGRID, IntAct23414517 details
ACTN2_HUMANAKTIP_HUMANBioGRID, IntAct23414517 details
ACTN2_HUMANASH2L_HUMANBioGRID, IntAct23414517 details
ACTN2_HUMANMAST2_HUMANBioGRID, IntAct23414517 details
ACTN2_HUMANMYPC2_HUMANBioGRID, IntAct23414517 details
ACTN2_HUMANPDLI3_HUMANBioGRID, IntAct23414517 25416956 25910212 31515488 details
ACTN2_HUMANSNAPN_HUMANBioGRID, IntAct23414517 details
ACTN2_HUMANTULP3_HUMANBioGRID, IntAct23414517 details
ACTN2_HUMANZYX_HUMANmbinfo11423549 details
ACTN2_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
ACTN2_HUMANCSRP3_HUMANMINT, UniProt15205937 24860983 details
ACTN2_HUMANSNAI1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
ACTN2_HUMANMOS_HUMANBioGRID, IntAct25416956 details
ACTN2_HUMANSAXO1_HUMANBioGRID, IntAct25416956 25910212 31515488 details
ACTN2_HUMANSP100_HUMANBioGRID, IntAct25416956 25910212 31515488 details
ACTN2_HUMANMYOZ2_HUMANBioGRID, HPRD, IntAct11842093 25416956 25910212 31515488 details
ACTN2_HUMANRTP5_HUMANBioGRID, IntAct25416956 31515488 32296183 details
ACTN2_HUMANBRM1L_HUMANBioGRID, IntAct25416956 31515488 32296183 details
ACTN2_HUMANMILK2_HUMANBioGRID, IntAct25416956 31515488 32296183 details
ACTN2_HUMANMYOTI_HUMANBioGRID, IntAct26871637 details
ACTN2_HUMANDUX1_HUMANBioGRID, IntAct26816005 details
ACTN2_HUMANSCRIB_HUMANMINT24550280 details
ACTN2_HUMANSYP2L_HUMANBioGRID, IntAct32296183 details
ACTN2_HUMANBAD_HUMANBioGRID, IntAct32296183 details
ACTN2_HUMANODF3B_HUMANBioGRID, IntAct32296183 details
ACTN2_HUMANZC21C_HUMANBioGRID, IntAct25910212 32296183 details
ACTN2_HUMANNKAP1_HUMANBioGRID, IntAct32296183 details
ACTN2_HUMAN5HT1B_HUMANBioGRID, IntAct32296183 details
ACTN2_HUMANUBP2_HUMANBioGRID, IntAct32296183 details
ACTN2_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
ACTN2_HUMANPSA1_HUMANBioGRID, IntAct32296183 details
ACTN2_HUMANRPP14_HUMANBioGRID, IntAct32296183 details
ACTN2_HUMANCNNM3_HUMANBioGRID, IntAct32296183 details
ACTN2_HUMANNRAP_HUMANUniProt15205937 details
ACTN2_HUMANH4_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANDYT2B_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANKATL2_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANFA50B_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANRM10_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANGOGA7_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANSYQ_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANRACK1_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANTOLIP_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANACTN1_HUMANBioGRID, IntAct22939629 25910212 details
ACTN2_HUMANANGL7_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANAT5G1_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANGATA3_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANPP1B_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANCRADD_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANZNRD2_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANGSTT1_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANSRP09_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANRABP2_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANCD27_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANSP17_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANCLC4D_HUMANBioGRID, IntAct25910212 details
ACTN2_HUMANPDLI1_HUMANBioGRID, HPRD, IntAct10861853 26186194 28514442 details
ACTN2_HUMANKCNN2_HUMANBioGRID, DIP19815520 details
ACTN2_HUMANCAC1D_HUMANDIP19815520 details
ACTN2_HUMANACTB_HUMANDIP20383143 details
ACTN2_HUMANDLG4_HUMANBioGRID, HPRD, MINT12435606 21653829 details
ACTN2_HUMANMYPN_HUMANBioGRID, HPRD11309420 details
ACTN2_HUMANNMDE2_HUMANBioGRID, HPRD9009191 details
ACTN2_HUMANADA12_HUMANBioGRID, HPRD10788519 details
ACTN2_HUMANTENN_HUMANBioGRID9817758 details
ACTN2_HUMANACTN3_HUMANBioGRID, HPRD10656685 9675099 details
ACTN2_HUMANNRIP1_HUMANBioGRID, HPRD15604093 details
ACTN2_HUMANKAT2B_HUMANBioGRID, HPRD15604093 details
ACTN2_HUMANMED14_HUMANBioGRID, HPRD15604093 details
ACTN2_HUMANSNW1_HUMANBioGRID, HPRD15604093 details
ACTN2_HUMANCENPR_HUMANBioGRID15604093 details
ACTN2_HUMANNR1I2_HUMANBioGRID, HPRD15604093 details
ACTN2_HUMANLDB3_HUMANBioGRID, HPRD10391924 10427098 details
ACTN2_HUMANFXL22_HUMANBioGRID22972877 details
ACTN2_HUMANERBIN_HUMANBioGRID15123239 details
ACTN2_HUMANCAN1_HUMANBioGRID, HPRD12358155 details
ACTN2_HUMANSYNP2_HUMANBioGRID20554076 details
ACTN2_HUMANCNDH2_HUMANBioGRID25910212 details
ACTN2_HUMANST7_HUMANBioGRID12809483 details
ACTN2_HUMANRGS9_HUMANBioGRID16510730 details
ACTN2_HUMANNMDZ1_HUMANBioGRID, HPRD16510730 9009191 9728925 9952395 details
ACTN2_HUMANNEB2_HUMANBioGRID20124353 details
ACTN2_HUMANCC187_HUMANBioGRID32296183 details
ACTN2_HUMANDUX5_HUMANBioGRID26816005 details
ACTN2_HUMANADIP_HUMANHPRD12446711 details
ACTN2_HUMANRAVR1_HUMANHPRD11724819 details
ACTN2_HUMANPKD2_HUMANHPRD15843396 details
ACTN2_HUMANNCOR1_HUMANHPRD15604093 details
ACTN2_HUMANTBA4A_HUMANIntAct16169070 details
ACTN2_HUMANEXOC1_HUMANIntAct31413325 details
ACTN2_HUMANARX_HUMANMINT21653829 details
ACTN2_HUMANCAC1C_HUMANMINT21653829 details
ACTN2_HUMANFXR1_HUMANMINT21653829 details
ACTN2_HUMANSHAN3_HUMANMINT21653829 details
ACTN2_HUMANTSC1_HUMANMINT21653829 details
ACTN2_HUMANSMCA2_HUMANMINT21653829 details
ACTN2_HUMANTSC2_HUMANMINT21653829 details
ACTN2_HUMANDLG1_HUMANBioGRID, HPRD12860415 details
ACTN2_HUMAN1433T_HUMANBioGRID20618440 details
ACTN2_HUMANHD_HUMANBioGRID30768638 details
ACTN2_HUMANABI1_HUMANBioGRID23414517 details
ACTN2_HUMANAA2AR_HUMANHPRD12837758 details
ACTN2_HUMANUTRN_HUMANHPRD12006649 details
ACTN2_HUMANLYAM2_HUMANHPRD8609175 details
ACTN2_HUMANKCC2D_HUMANHPRD16120608 details
ACTN2_HUMANNCOA2_HUMANHPRD15072553 details
ACTN2_HUMANLRRC7_HUMANHPRD16120608 details
ACTN2_HUMANPALLD_HUMANHPRD10931874 details
ACTN2_HUMANMYOZ3_HUMANHPRD11842093 details
ACTN2_HUMANES8L1_HUMANHPRD14565974 details