Entity Details

Primary name VGFR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35968
EntryNameVGFR2_HUMAN
FullNameVascular endothelial growth factor receptor 2
TaxID9606
Evidenceevidence at protein level
Length1356
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesKDR

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003158 endothelium development
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005768 endosome
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0010595 positive regulation of endothelial cell migration
GO:0010629 negative regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0016239 positive regulation of macroautophagy
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0030054 cell junction
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0033674 positive regulation of kinase activity
GO:0035162 embryonic hemopoiesis
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038085 vascular endothelial growth factor binding
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0045446 endothelial cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050927 positive regulation of positive chemotaxis
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051879 Hsp90 protein binding
GO:0051894 positive regulation of focal adhesion assembly
GO:0051901 positive regulation of mitochondrial depolarization
GO:0061042 vascular wound healing
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090141 positive regulation of mitochondrial fission
GO:0097443 sorting endosome
GO:1904881 cellular response to hydrogen sulfide
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2001214 positive regulation of vasculogenesis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Early endosome
Endoplasmic reticulum
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2)FamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041348 VEGFR-2, Transmembrane domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB04727 1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]ureaDrugbanksmall molecule
DB04849 CediranibDrugbanksmall molecule
DB04879 VatalanibDrugbanksmall molecule
DB05014 XL999Drugbanksmall molecule
DB05075 TG-100801Drugbanksmall molecule
DB05146 XL820Drugbanksmall molecule
DB05198 CYC116Drugbanksmall molecule
DB05578 RamucirumabDrugbankbiotech
DB05931 PegdinetanibDrugbanksmall molecule
DB05984 RAF-265Drugbanksmall molecule
DB06080 ABT-869Drugbanksmall molecule
DB06101 IMC-1C11Drugbankbiotech
DB06436 SemaxanibDrugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB06626 AxitinibDrugbanksmall molecule
DB06938 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamideDrugbanksmall molecule
DB07183 N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamideDrugbanksmall molecule
DB07274 N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamideDrugbanksmall molecule
DB07326 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamideDrugbanksmall molecule
DB07333 N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDEDrugbanksmall molecule
DB07334 N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINEDrugbanksmall molecule
DB07514 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-oneDrugbanksmall molecule
DB07528 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-oneDrugbanksmall molecule
DB07537 N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamideDrugbanksmall molecule
DB08042 N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamineDrugbanksmall molecule
DB08519 N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamineDrugbanksmall molecule
DB08875 CabozantinibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB12307 ForetinibDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

88 interactions

InteractorPartnerSourcesPublicationsLink
VGFR2_HUMANSHC1_HUMANBioGRID, HPRD, MINT10319320 10749680 11950700 12214271 details
VGFR2_HUMANVEGFA_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct, matrixdb, MINT12716911 1417831 16423422 16763549 16901919 17318185 18325345 19818105 20145116 20660291 21596751 22897854 23374253 23583373 25644401 28303365 30236477 31932617 8621427 details
VGFR2_HUMANPTPRJ_HUMANMINT18936167 details
VGFR2_HUMANSRC_HUMANBioGRID, HPRD, Molecular Connections, UniProt10455194 12509223 16966330 18194650 18377662 18662404 19050761 22689825 details
VGFR2_HUMANPTN6_HUMANBioGRID, HPRD, MINT, Molecular Connections12887919 16453023 18377662 28065597 28183800 9405464 details
VGFR2_HUMANPLCG1_HUMANBioGRID, HPRD, MINT12598525 9398617 details
VGFR2_HUMANFBW1B_HUMANBioGRID, MINT21900206 22711876 details
VGFR2_HUMANAIMP2_HUMANBioGRID, MINT21900206 details
VGFR2_HUMANPGBM_HUMANmatrixdb, MINT21596751 23374253 details
VGFR2_HUMANPDCD6_HUMANUniProt21893193 details
VGFR2_HUMANVGFR2_HUMANbhf-ucl, BioGRID, DIP, HPRD10102632 10368301 10579917 10749680 16007196 17293873 20080685 20190562 20660291 28303365 details
VGFR2_HUMANGREM1_HUMANbhf-ucl20660291 details
VGFR2_HUMANLEG1_HUMANIntAct24529377 details
VGFR2_HUMANVEGFC_HUMANBioGRID, DIP, HPRD11332691 18593464 20145116 details
VGFR2_HUMANPPM1A_HUMANBioGRID, MINT28065597 details
VGFR2_HUMANDUS19_HUMANBioGRID, MINT28065597 details
VGFR2_HUMANILKAP_HUMANBioGRID, MINT28065597 details
VGFR2_HUMANPPM1B_HUMANBioGRID, MINT28065597 details
VGFR2_HUMANSTYX_HUMANBioGRID, MINT28065597 details
VGFR2_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
VGFR2_HUMANPTN11_HUMANBioGRID, HPRD, MINT16339483 28065597 9405464 details
VGFR2_HUMANPTN12_HUMANBioGRID, MINT28065597 details
VGFR2_HUMANHTRA4_HUMANIntAct30601675 details
VGFR2_HUMANKALM_HUMANMINT31932617 details
VGFR2_HUMANANXA5_HUMANBioGRID, HPRD10329451 details
VGFR2_HUMANSHC2_HUMANBioGRID, HPRD10749680 12214271 9790910 details
VGFR2_HUMANVGFR1_HUMANBioGRID, HPRD10865839 12796773 25387128 details
VGFR2_HUMANVEGFD_HUMANBioGRID, HPRD9435229 details
VGFR2_HUMANGRB10_HUMANBioGRID, HPRD11494124 details
VGFR2_HUMANPPAC_HUMANBioGRID, HPRD10608891 details
VGFR2_HUMANCOIA1_HUMANBioGRID, HPRD12029087 details
VGFR2_HUMANCBL_HUMANBioGRID, HPRD12649282 17372230 20011623 details
VGFR2_HUMANFBW1A_HUMANBioGRID21402774 22711876 details
VGFR2_HUMANKC1D_HUMANBioGRID22711876 details
VGFR2_HUMANIQGA1_HUMANBioGRID, HPRD15217908 19050761 details
VGFR2_HUMANFBX25_HUMANBioGRID23940030 details
VGFR2_HUMANSH22A_HUMANBioGRID, HPRD10692392 15962004 22689825 details
VGFR2_HUMANA4_HUMANBioGRID19818105 details
VGFR2_HUMANMK01_HUMANBioGRID20190562 details
VGFR2_HUMANGBRAP_HUMANBioGRID24686084 details
VGFR2_HUMANPEDF_HUMANBioGRID16901919 details
VGFR2_HUMANGRDN_HUMANBioGRID25187647 details
VGFR2_HUMANPDCL3_HUMANBioGRID23792958 details
VGFR2_HUMANATR_HUMANHPRD10749680 details
VGFR2_HUMANCADH5_HUMANBioGRID, HPRD, MINT, Molecular Connections10428027 11950700 18662404 25657827 details
VGFR2_HUMANNRP1_HUMANBioGRID, HPRD, IntAct, MINT11333271 11886873 11948691 16763549 17222790 19857463 26037503 details
VGFR2_HUMANVGFR3_HUMANHPRD, IntAct, MINT15474514 16530705 20224550 21130043 details
VGFR2_HUMANGRB2_HUMANBioGRID, HPRD, MINT10319320 16966330 details
VGFR2_HUMANNCK1_HUMANBioGRID, HPRD, MINT12214271 16966330 9405464 details
VGFR2_HUMANFYN_HUMANHPRD, MINT16966330 7929439 details
VGFR2_HUMANSHB_HUMANBioGRID, HPRD, MINT15026417 details
VGFR2_HUMANMET_HUMANIntAct22789536 details
VGFR2_HUMANCRK_HUMANHPRD, IntAct15051508 23397142 details
VGFR2_HUMANITA2_HUMANmatrixdb21596751 details
VGFR2_HUMANEEA1_HUMANIntAct23799140 details
VGFR2_HUMANPGFRB_HUMANDIP18997771 details
VGFR2_HUMANLRP8_HUMANDIP30139844 details
VGFR2_HUMANITB1_HUMANBioGRID, IntAct12114318 18931684 details
VGFR2_HUMANPLXA1_HUMANBioGRID14977921 details
VGFR2_HUMANRASA1_HUMANBioGRID, HPRD10319320 details
VGFR2_HUMANCUL1_HUMANBioGRID22711876 details
VGFR2_HUMANEPN1_HUMANBioGRID23187125 details
VGFR2_HUMANMYO1C_HUMANBioGRID23262137 details
VGFR2_HUMANCAV1_HUMANBioGRID, HPRD12529448 23262137 details
VGFR2_HUMANTXNIP_HUMANBioGRID23393387 details
VGFR2_HUMANRAB5A_HUMANBioGRID23393387 details
VGFR2_HUMANITB3_HUMANBioGRID, HPRD10022831 25644401 details
VGFR2_HUMANIL3RB_HUMANBioGRID, HPRD16007196 details
VGFR2_HUMANDYN2_HUMANBioGRID, HPRD16049137 details
VGFR2_HUMANSCUB2_HUMANBioGRID27834687 details
VGFR2_HUMANTNR25_HUMANBioGRID28183800 details
VGFR2_HUMANITA5_HUMANBioGRID12114318 details
VGFR2_HUMANUBC_HUMANBioGRID23792958 details
VGFR2_HUMANHS90A_HUMANBioGRID, HPRD12820653 15247219 details
VGFR2_HUMANVINC_HUMANBioGRID12820653 details
VGFR2_HUMANPLXD1_HUMANBioGRID26037503 details
VGFR2_HUMANUBP14_HUMANBioGRID32908134 details
VGFR2_HUMANPLCG2_HUMANHPRD9398617 details
VGFR2_HUMANP2RY2_HUMANHPRD15175347 details
VGFR2_HUMANGNA11_HUMANHPRD12670961 details
VGFR2_HUMANSTAT1_HUMANHPRD10961983 details
VGFR2_HUMANGNAQ_HUMANHPRD12670961 details
VGFR2_HUMANBMX_HUMANHPRD14532277 details
VGFR2_HUMANFRS2_HUMANHPRD12154000 details
VGFR2_HUMANYES_HUMANHPRD7929439 details
VGFR2_HUMANTIMP3_HUMANHPRD12652295 details
VGFR2_HUMANCTNB1_HUMANHPRD12920240 details
VGFR2_HUMANSYGP1_HUMANHPRD9405464 details