Entity Details

Primary name TGFR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36897
EntryNameTGFR1_HUMAN
FullNameTGF-beta receptor type-1
TaxID9606
Evidenceevidence at protein level
Length503
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesTGFBR1

GO terms

Show/Hide Table
GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001501 skeletal system development
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001824 blastocyst development
GO:0001837 epithelial to mesenchymal transition
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002088 lens development in camera-type eye
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003223 ventricular compact myocardium morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0008354 germ cell migration
GO:0008584 male gonad development
GO:0009791 post-embryonic development
GO:0009952 anterior/posterior pattern specification
GO:0009986 cell surface
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016020 membrane
GO:0016361 activin receptor activity, type I
GO:0016579 protein deubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030199 collagen fibril organization
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031396 regulation of protein ubiquitination
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032924 activin receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0042060 wound healing
GO:0042118 endothelial cell activation
GO:0043062 extracellular structure organization
GO:0043235 receptor complex
GO:0043393 regulation of protein binding
GO:0043542 endothelial cell migration
GO:0045121 membrane raft
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0048538 thymus development
GO:0048663 neuron fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048762 mesenchymal cell differentiation
GO:0048844 artery morphogenesis
GO:0048870 cell motility
GO:0050431 transforming growth factor beta binding
GO:0051272 positive regulation of cellular component movement
GO:0051491 positive regulation of filopodium assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060017 parathyroid gland development
GO:0060021 roof of mouth development
GO:0060037 pharyngeal system development
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0060978 angiogenesis involved in coronary vascular morphogenesis
GO:0060982 coronary artery morphogenesis
GO:0070411 I-SMAD binding
GO:0070723 response to cholesterol
GO:0071363 cellular response to growth factor stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905075 positive regulation of tight junction disassembly
GO:1905223 epicardium morphogenesis
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cell surface
Membrane raft

Domains

Show/Hide Table
DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR003605 GS domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB03921 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)QuinolineDrugbanksmall molecule
DB04434 Naphthyridine InhibitorDrugbanksmall molecule
DB04480 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]PyrazoleDrugbanksmall molecule
DB07152 N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamideDrugbanksmall molecule
DB07267 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amineDrugbanksmall molecule
DB08450 N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amineDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

194 interactions

InteractorPartnerSourcesPublicationsLink
TGFR1_HUMANFKB1A_HUMANBioGRID, HPRD, IntAct10025408 16049346 24658140 7518616 7791754 9346894 details
TGFR1_HUMANSMAD2_HUMANBioGRID, HPRD, MINT11102446 12543979 15350225 18511908 19139564 25872870 29490279 9346908 9525694 9892009 details
TGFR1_HUMANSTRAP_HUMANBioGRID, HPRD, IntAct10757800 17314099 9856985 details
TGFR1_HUMANTGFB1_HUMANBioGRID, HPRD, I2D10716993 15597342 20856203 8235612 details
TGFR1_HUMANACVR1_HUMANHPRD, IntAct15761153 24658140 details
TGFR1_HUMANTGFR2_HUMANBioGRID, DIP, HPRD11102446 11483955 19556242 19758997 21791611 23868260 25825445 7890683 8576253 details
TGFR1_HUMANA2GL_HUMANDIP23868260 details
TGFR1_HUMANEGLN_HUMANBioGRID, DIP, HPRD12015308 15702480 18974388 23868260 9872992 details
TGFR1_HUMANBMPR2_HUMANBioGRID7791754 7890683 details
TGFR1_HUMANSMAD7_HUMANBioGRID, HPRD10757800 11163210 12151385 14657019 14722617 15148321 15359284 15946939 16027725 17314099 19758997 20663871 21791611 22624557 23027871 25149540 31746425 9215638 9335507 details
TGFR1_HUMANFNTA_HUMANBioGRID, HPRD8530343 details
TGFR1_HUMANAP2B1_HUMANBioGRID, HPRD12429842 details
TGFR1_HUMANCD44_HUMANBioGRID, HPRD12145287 15597342 details
TGFR1_HUMAN2ABA_HUMANBioGRID, HPRD9774674 details
TGFR1_HUMANCLUS_HUMANBioGRID, HPRD8555189 details
TGFR1_HUMANTRAF6_HUMANBioGRID, HPRD18758450 18922473 24103590 25622187 26807171 details
TGFR1_HUMANHS90A_HUMANBioGRID18591668 21465483 22848678 details
TGFR1_HUMANSKI_HUMANBioGRID20959473 details
TGFR1_HUMANT22D1_HUMANBioGRID21791611 details
TGFR1_HUMANUBP4_HUMANBioGRID22706160 30335615 details
TGFR1_HUMANMYOC_HUMANBioGRID, HPRD16289162 details
TGFR1_HUMANBAMBI_HUMANBioGRID19758997 details
TGFR1_HUMANSMAD3_HUMANBioGRID, HPRD12543979 19758997 25872870 9311995 details
TGFR1_HUMANPAK1_HUMANBioGRID, HPRD15761153 details
TGFR1_HUMANNRP1_HUMANBioGRID20675371 21186301 details
TGFR1_HUMANRANB9_HUMANBioGRID24103590 details
TGFR1_HUMANOTUB1_HUMANBioGRID25872870 details
TGFR1_HUMANTGFA1_HUMANBioGRID, HPRD11278302 9545258 details
TGFR1_HUMANDP13A_HUMANBioGRID26583432 details
TGFR1_HUMANFKB1B_HUMANBioGRID16049346 details
TGFR1_HUMANPSDE_HUMANBioGRID30745168 details
TGFR1_HUMANUBP2_HUMANBioGRID29490279 details
TGFR1_HUMANMYT1L_HUMANBioGRID29490279 details
TGFR1_HUMANTRAP1_HUMANHPRD11278302 9545258 details
TGFR1_HUMAN1433Z_HUMANIntAct19732720 details
TGFR1_HUMANTGFB3_HUMANHPRD, MINT11850637 12060054 12607775 21423151 details
TGFR1_HUMANITA5_HUMANMINT22940691 details
TGFR1_HUMANDLG5_HUMANMINT23624079 details
TGFR1_HUMANM3K20_HUMANBioGRID, HPRD15465036 details
TGFR1_HUMANSMUF1_HUMANBioGRID11278251 12857866 14657019 details
TGFR1_HUMANSMUF2_HUMANBioGRID, HPRD11163210 14722617 21791611 22624557 23973329 25149540 26679521 31746425 details
TGFR1_HUMANP85A_HUMANBioGRID, HPRD15657037 9435577 details
TGFR1_HUMANP85B_HUMANBioGRID, HPRD9435577 details
TGFR1_HUMANSNX6_HUMANBioGRID, HPRD11279102 details
TGFR1_HUMANCAV1_HUMANBioGRID, HPRD11102446 30745168 details
TGFR1_HUMANSMAD4_HUMANBioGRID, HPRD11102446 15761153 8774881 details
TGFR1_HUMANM3K7_HUMANBioGRID, HPRD18758450 19556242 23973329 details
TGFR1_HUMANMK14_HUMANBioGRID18758450 details
TGFR1_HUMANEP300_HUMANBioGRID21629263 details
TGFR1_HUMANHSP74_HUMANBioGRID19995547 details
TGFR1_HUMANSKIL_HUMANBioGRID20959473 details
TGFR1_HUMANITCH_HUMANBioGRID15350225 details
TGFR1_HUMANHMMR_HUMANBioGRID22610405 details
TGFR1_HUMANUBP11_HUMANBioGRID22773947 details
TGFR1_HUMANUBP15_HUMANBioGRID22344298 23973329 24850914 details
TGFR1_HUMANTOLIP_HUMANBioGRID23027871 details
TGFR1_HUMANSMAD6_HUMANBioGRID, HPRD20663871 9335505 9436979 details
TGFR1_HUMANTAB2_HUMANBioGRID19556242 details
TGFR1_HUMANCDC42_HUMANBioGRID15761153 details
TGFR1_HUMANARHG6_HUMANBioGRID, HPRD15761153 details
TGFR1_HUMANKCNKI_HUMANBioGRID, HPRD15761153 details
TGFR1_HUMANFBX34_HUMANBioGRID, HPRD15761153 details
TGFR1_HUMANOXSR1_HUMANBioGRID, HPRD15761153 details
TGFR1_HUMANPP16B_HUMANBioGRID15761153 details
TGFR1_HUMANOCLN_HUMANBioGRID, HPRD15761153 details
TGFR1_HUMANSPTB2_HUMANBioGRID12543979 details
TGFR1_HUMANANK1_HUMANBioGRID12543979 details
TGFR1_HUMANTPM1_HUMANBioGRID12543979 details
TGFR1_HUMANPEG10_HUMANBioGRID15611116 details
TGFR1_HUMANACVL1_HUMANBioGRID, HPRD14580334 8242742 details
TGFR1_HUMANTRAF4_HUMANBioGRID23973329 details
TGFR1_HUMANPSN1_HUMANBioGRID24399296 details
TGFR1_HUMANNOTC1_HUMANBioGRID24399296 details
TGFR1_HUMANPAR6A_HUMANBioGRID, HPRD15761148 15761153 details
TGFR1_HUMANSH3K1_HUMANBioGRID26169354 details
TGFR1_HUMANRASF1_HUMANBioGRID27292796 details
TGFR1_HUMANVHL_HUMANBioGRID29662646 details
TGFR1_HUMANTGFR1_HUMANHPRD9472030 details
TGFR1_HUMANTGFB2_HUMANHPRD11157754 details
TGFR1_HUMANAMHR2_HUMANHPRD11420127 details
TGFR1_HUMANSMAD1_HUMANHPRD10085121 9136927 9748228 details
TGFR1_HUMANBMR1B_HUMANHPRD11420127 details
TGFR1_HUMANZFYV9_HUMANHPRD9865696 details
TGFR1_HUMANPML_HUMANHPRD15356634 details
TGFR1_HUMANCTNB1_HUMANHPRD12000714 details
TGFR1_HUMANAPC5_HUMANHPRD15761153 details
TGFR1_HUMANARL4D_HUMANHPRD15761153 details
TGFR1_HUMANRHG15_HUMANHPRD15761153 details
TGFR1_HUMANARL8B_HUMANHPRD15761153 details
TGFR1_HUMANASH2L_HUMANHPRD15761153 details
TGFR1_HUMANAURKB_HUMANHPRD15761153 details
TGFR1_HUMANBTBD2_HUMANHPRD15761153 details
TGFR1_HUMANCDC20_HUMANHPRD15761153 details
TGFR1_HUMANBORG4_HUMANHPRD15761153 details
TGFR1_HUMANCDK4_HUMANHPRD15761153 details
TGFR1_HUMANCDK6_HUMANHPRD15761153 details
TGFR1_HUMANCDKL1_HUMANHPRD15761153 details
TGFR1_HUMANCHIN_HUMANHPRD15761153 details
TGFR1_HUMANCHIO_HUMANHPRD15761153 details
TGFR1_HUMANIKKA_HUMANHPRD15761153 details
TGFR1_HUMANKC1A_HUMANHPRD15761153 details
TGFR1_HUMANCSK22_HUMANHPRD15761153 details
TGFR1_HUMANCUL5_HUMANHPRD15761153 details
TGFR1_HUMANDAPK2_HUMANHPRD15761153 details
TGFR1_HUMANPREX2_HUMANHPRD15761153 details
TGFR1_HUMANDS13A_HUMANHPRD15761153 details
TGFR1_HUMANE2AK4_HUMANHPRD15761153 details
TGFR1_HUMANENC1_HUMANHPRD15761153 details
TGFR1_HUMANFANCL_HUMANHPRD15761153 details
TGFR1_HUMANFXL12_HUMANHPRD15761153 details
TGFR1_HUMANGNA13_HUMANHPRD15761153 details
TGFR1_HUMANGBB2_HUMANHPRD15761153 details
TGFR1_HUMANGBB3_HUMANHPRD15761153 details
TGFR1_HUMANIKKB_HUMANHPRD15761153 details
TGFR1_HUMANDCAF6_HUMANHPRD15761153 details
TGFR1_HUMANITK_HUMANHPRD15761153 details
TGFR1_HUMANKTNB1_HUMANHPRD15761153 details
TGFR1_HUMANKLHL1_HUMANHPRD15761153 details
TGFR1_HUMANLIMS1_HUMANHPRD15761153 details
TGFR1_HUMANMYO3A_HUMANHPRD15761153 details
TGFR1_HUMANNAT8_HUMANHPRD15761153 details
TGFR1_HUMANNEK6_HUMANHPRD15761153 details
TGFR1_HUMANNEK8_HUMANHPRD15761153 details
TGFR1_HUMANKBRS1_HUMANHPRD15761153 details
TGFR1_HUMANNUAK2_HUMANHPRD15761153 details
TGFR1_HUMANNUP37_HUMANHPRD15761153 details
TGFR1_HUMANCDK17_HUMANHPRD15761153 details
TGFR1_HUMANCDK14_HUMANHPRD15761153 details
TGFR1_HUMANPKHB1_HUMANHPRD15761153 details
TGFR1_HUMANPLEK_HUMANHPRD15761153 details
TGFR1_HUMANPLK4_HUMANHPRD15761153 details
TGFR1_HUMANPP2BC_HUMANHPRD15761153 details
TGFR1_HUMANPPP6_HUMANHPRD15761153 details
TGFR1_HUMANPREB_HUMANHPRD15761153 details
TGFR1_HUMANPRP4_HUMANHPRD15761153 details
TGFR1_HUMANRAB13_HUMANHPRD15761153 details
TGFR1_HUMANRAB25_HUMANHPRD15761153 details
TGFR1_HUMANRB33B_HUMANHPRD15761153 details
TGFR1_HUMANRAB38_HUMANHPRD15761153 details
TGFR1_HUMANRAB3B_HUMANHPRD15761153 details
TGFR1_HUMANRAB6B_HUMANHPRD15761153 details
TGFR1_HUMANRAN_HUMANHPRD15761153 details
TGFR1_HUMANRAP2A_HUMANHPRD15761153 details
TGFR1_HUMANRHES_HUMANHPRD15761153 details
TGFR1_HUMANRASLC_HUMANHPRD15761153 details
TGFR1_HUMANREBL1_HUMANHPRD15761153 details
TGFR1_HUMANRHOA_HUMANHPRD15761153 details
TGFR1_HUMANRHOD_HUMANHPRD15761153 details
TGFR1_HUMANRHOG_HUMANHPRD15761153 details
TGFR1_HUMANRHOH_HUMANHPRD15761153 details
TGFR1_HUMANRHOJ_HUMANHPRD15761153 details
TGFR1_HUMANRHPN2_HUMANHPRD15761153 details
TGFR1_HUMANGOLI_HUMANHPRD15761153 details
TGFR1_HUMANRN146_HUMANHPRD15761153 details
TGFR1_HUMANRNF5_HUMANHPRD15761153 details
TGFR1_HUMANRS27A_HUMANHPRD15761153 details
TGFR1_HUMANOPSX_HUMANHPRD15761153 details
TGFR1_HUMANRTKN_HUMANHPRD15761153 details
TGFR1_HUMANSAMD8_HUMANHPRD15761153 details
TGFR1_HUMANSAT2_HUMANHPRD15761153 details
TGFR1_HUMANSKAP2_HUMANHPRD15761153 details
TGFR1_HUMANSNTG1_HUMANHPRD15761153 details
TGFR1_HUMANSOCS6_HUMANHPRD15761153 details
TGFR1_HUMANSTK35_HUMANHPRD15761153 details
TGFR1_HUMANCHIP_HUMANHPRD15761153 details
TGFR1_HUMANSTX8_HUMANHPRD15761153 details
TGFR1_HUMANSTYL1_HUMANHPRD15761153 details
TGFR1_HUMANTNNT1_HUMANHPRD15761153 details
TGFR1_HUMANTSSK1_HUMANHPRD15761153 details
TGFR1_HUMANTSSK4_HUMANHPRD15761153 details
TGFR1_HUMANTTC1_HUMANHPRD15761153 details
TGFR1_HUMANRL40_HUMANHPRD15761153 details
TGFR1_HUMANUBB_HUMANHPRD15761153 details
TGFR1_HUMANUBD_HUMANHPRD15761153 details
TGFR1_HUMANUB2E3_HUMANHPRD15761153 details
TGFR1_HUMANUBP45_HUMANHPRD15761153 details
TGFR1_HUMANMELT_HUMANHPRD15761153 details
TGFR1_HUMANWDR13_HUMANHPRD15761153 details
TGFR1_HUMANWDR33_HUMANHPRD15761153 details
TGFR1_HUMANDCA12_HUMANHPRD15761153 details
TGFR1_HUMANWDR61_HUMANHPRD15761153 details
TGFR1_HUMANXIAP_HUMANHPRD11356828 details
TGFR1_HUMANRPAP3_HUMANHPRD15761153 details
TGFR1_HUMANOSR1_HUMANHPRD15761153 details
TGFR1_HUMANUBXN1_HUMANHPRD15761153 details
TGFR1_HUMANKLH35_HUMANHPRD15761153 details
TGFR1_HUMANPKHJ1_HUMANHPRD15761153 details
TGFR1_HUMANTTC27_HUMANHPRD15761153 details
TGFR1_HUMANSG196_HUMANHPRD15761153 details
TGFR1_HUMANTTPAL_HUMANHPRD15761153 details
TGFR1_HUMANRHG31_HUMANHPRD15761153 details
TGFR1_HUMANUBE2Z_HUMANHPRD15761153 details
TGFR1_HUMANRGS19_HUMANHPRD15761153 details
TGFR1_HUMANSQSTM_HUMANHPRD15761153 details