Entity Details

Primary name PEDF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36955
EntryNamePEDF_HUMAN
FullNamePigment epithelium-derived factor
TaxID9606
Evidenceevidence at protein level
Length418
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesSERPINF1

GO terms

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GOName
GO:0001822 kidney development
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0007568 aging
GO:0007614 short-term memory
GO:0010447 response to acidic pH
GO:0010596 negative regulation of endothelial cell migration
GO:0010629 negative regulation of gene expression
GO:0010951 negative regulation of endopeptidase activity
GO:0010976 positive regulation of neuron projection development
GO:0016525 negative regulation of angiogenesis
GO:0042470 melanosome
GO:0042698 ovulation cycle
GO:0043203 axon hillock
GO:0046685 response to arsenic-containing substance
GO:0048471 perinuclear region of cytoplasm
GO:0050728 negative regulation of inflammatory response
GO:0050769 positive regulation of neurogenesis
GO:0060041 retina development in camera-type eye
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071279 cellular response to cobalt ion
GO:0071300 cellular response to retinoic acid
GO:0071333 cellular response to glucose stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:1901215 negative regulation of neuron death
GO:1901652 response to peptide

Subcellular Location

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Subcellular Location
Melanosome
Secreted

Domains

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DomainNameCategoryType
IPR000215 Serpin familyFamilyFamily
IPR023795 Serpin, conserved siteSiteConserved site
IPR023796 Serpin domainDomainDomain
IPR033832 Pigment epithelium derived factor, serpin domainDomainDomain
IPR036186 Serpin superfamilyFamilyHomologous superfamily
IPR042178 Serpin superfamily, domain 1FamilyHomologous superfamily
IPR042185 Serpin superfamily, domain 2FamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule