Entity Details

Primary name TGFR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP37173
EntryNameTGFR2_HUMAN
FullNameTGF-beta receptor type-2
TaxID9606
Evidenceevidence at protein level
Length567
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesTGFBR2

GO terms

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GOName
GO:0001568 blood vessel development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001947 heart looping
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002088 lens development in camera-type eye
GO:0002651 positive regulation of tolerance induction to self antigen
GO:0002663 positive regulation of B cell tolerance induction
GO:0002666 positive regulation of T cell tolerance induction
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003274 endocardial cushion fusion
GO:0003430 growth plate cartilage chondrocyte growth
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005026 transforming growth factor beta receptor activity, type II
GO:0005524 ATP binding
GO:0005539 glycosaminoglycan binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006468 protein phosphorylation
GO:0006898 receptor-mediated endocytosis
GO:0006915 apoptotic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007219 Notch signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007369 gastrulation
GO:0007420 brain development
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell population proliferation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0009897 external side of plasma membrane
GO:0010468 regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016021 integral component of membrane
GO:0017002 activin-activated receptor activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 animal organ regeneration
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0032147 activation of protein kinase activity
GO:0034713 type I transforming growth factor beta receptor binding
GO:0034714 type III transforming growth factor beta receptor binding
GO:0035162 embryonic hemopoiesis
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0043011 myeloid dendritic cell differentiation
GO:0043235 receptor complex
GO:0043415 positive regulation of skeletal muscle tissue regeneration
GO:0043627 response to estrogen
GO:0045121 membrane raft
GO:0045766 positive regulation of angiogenesis
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048185 activin binding
GO:0048545 response to steroid hormone
GO:0048565 digestive tract development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050431 transforming growth factor beta binding
GO:0051138 positive regulation of NK T cell differentiation
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060412 ventricular septum morphogenesis
GO:0060434 bronchus morphogenesis
GO:0060440 trachea formation
GO:0060443 mammary gland morphogenesis
GO:0060463 lung lobe morphogenesis
GO:0062009 secondary palate development
GO:0070723 response to cholesterol
GO:0071363 cellular response to growth factor stimulus
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905317 inferior endocardial cushion morphogenesis
GO:1990086 lens fiber cell apoptotic process
GO:1990428 miRNA transport
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation

Subcellular Location

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Subcellular Location
Cell membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015013 Transforming growth factor beta receptor 2 ectodomainDomainDomain
IPR017194 Transforming growth factor-beta receptor, type IIFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule

Interactions

146 interactions

InteractorPartnerSourcesPublicationsLink
TGFR2_HUMANTGFR1_HUMANBioGRID, DIP, HPRD11102446 11483955 19556242 19758997 21791611 23868260 25825445 7890683 8576253 details
TGFR2_HUMANIDHC_HUMANIntAct32814053 details
TGFR2_HUMANBAHD1_HUMANIntAct32814053 details
TGFR2_HUMANKLK8_HUMANIntAct32814053 details
TGFR2_HUMANMFS10_HUMANIntAct32814053 details
TGFR2_HUMANCCNB2_HUMANBioGRID, HPRD9926943 details
TGFR2_HUMANTGFR2_HUMANHPRD11163210 11279102 7890683 details
TGFR2_HUMANDAXX_HUMANBioGRID, MINT11483955 details
TGFR2_HUMANTGFB3_HUMANBioGRID, HPRD, IntAct, MINT11157754 11382746 11850637 12729750 21423151 8106553 9872992 details
TGFR2_HUMANRECO_HUMANBioGRID, IntAct21988832 details
TGFR2_HUMANSCUB3_HUMANI2D21441952 details
TGFR2_HUMANF104A_HUMANIntAct32814053 details
TGFR2_HUMANRILP_HUMANIntAct32814053 details
TGFR2_HUMANARFG3_HUMANIntAct32814053 details
TGFR2_HUMANU1SBP_HUMANIntAct32814053 details
TGFR2_HUMANRL37A_HUMANIntAct32814053 details
TGFR2_HUMANPGFRA_HUMANBioGRID, IntAct21988832 details
TGFR2_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
TGFR2_HUMANTCPZ_HUMANIntAct32814053 details
TGFR2_HUMANMYC_HUMANIntAct32814053 details
TGFR2_HUMANISY1_HUMANIntAct32814053 details
TGFR2_HUMANSUV91_HUMANIntAct32814053 details
TGFR2_HUMANAP2B1_HUMANBioGRID, HPRD12429842 details
TGFR2_HUMANTGFB1_HUMANBioGRID, HPRD, I2D, MINT11157754 20856203 20860622 21054789 21441952 7935686 8242742 8389764 details
TGFR2_HUMANTRMO_HUMANBioGRID, MINT24412244 details
TGFR2_HUMANPTN_HUMANIntAct32814053 details
TGFR2_HUMANPAIRB_HUMANIntAct32814053 details
TGFR2_HUMANCTL5_HUMANIntAct32814053 details
TGFR2_HUMANPAK1_HUMANBioGRID, HPRD15761153 details
TGFR2_HUMANA2GL_HUMANDIP23868260 details
TGFR2_HUMANELAV4_HUMANIntAct32814053 details
TGFR2_HUMANITAV_HUMANIntAct32814053 details
TGFR2_HUMANMAVS_HUMANIntAct32814053 details
TGFR2_HUMANSGMR1_HUMANIntAct32814053 details
TGFR2_HUMANLNX2_HUMANIntAct32814053 details
TGFR2_HUMANTRI43_HUMANIntAct32814053 details
TGFR2_HUMANEGLN_HUMANBioGRID, HPRD12015308 15702480 9872992 details
TGFR2_HUMANCBL_HUMANBioGRID23290524 31315051 details
TGFR2_HUMANFANCC_HUMANBioGRID, MINT24412244 details
TGFR2_HUMANSP6_HUMANIntAct19088080 32814053 details
TGFR2_HUMANT3JAM_HUMANIntAct32814053 details
TGFR2_HUMANIN80C_HUMANIntAct32814053 details
TGFR2_HUMANFSTL1_HUMANMINT20860622 details
TGFR2_HUMANRAPSN_HUMANIntAct32814053 details
TGFR2_HUMANPIGV_HUMANIntAct32814053 details
TGFR2_HUMANGOPC_HUMANBioGRID, IntAct21988832 details
TGFR2_HUMANZN510_HUMANBioGRID, MINT24412244 details
TGFR2_HUMANCADH1_HUMANIntAct32814053 details
TGFR2_HUMANWT1_HUMANIntAct32814053 details
TGFR2_HUMANPLPR1_HUMANIntAct32814053 details
TGFR2_HUMANATX3_HUMANIntAct32814053 details
TGFR2_HUMANCLUS_HUMANBioGRID, HPRD8555189 details
TGFR2_HUMANTRAF6_HUMANBioGRID18922473 26807171 details
TGFR2_HUMANNPL4_HUMANBioGRID, IntAct28443643 32814053 details
TGFR2_HUMANSTRAP_HUMANBioGRID, HPRD10757800 9856985 details
TGFR2_HUMANDD19B_HUMANIntAct32814053 details
TGFR2_HUMANPCSK7_HUMANIntAct32814053 details
TGFR2_HUMANDNSL1_HUMANIntAct32814053 details
TGFR2_HUMANSGCA_HUMANIntAct32814053 details
TGFR2_HUMANACVR1_HUMANBioGRID7890683 details
TGFR2_HUMANDYLT4_HUMANHPRD16982625 details
TGFR2_HUMANNSD3_HUMANIntAct32814053 details
TGFR2_HUMANATX1_HUMANIntAct32814053 details
TGFR2_HUMANCCNB1_HUMANBioGRID, HPRD9926943 details
TGFR2_HUMANA4_HUMANBioGRID21244100 21832049 details
TGFR2_HUMANMYNN_HUMANIntAct32814053 details
TGFR2_HUMANDPYL4_HUMANIntAct32814053 details
TGFR2_HUMANRBM5_HUMANIntAct32814053 details
TGFR2_HUMANHS90A_HUMANBioGRID18591668 22848678 details
TGFR2_HUMANTDGF1_HUMANBioGRID28126904 details
TGFR2_HUMANRHBD2_HUMANIntAct32814053 details
TGFR2_HUMANPSDE_HUMANBioGRID28443643 30745168 31685442 details
TGFR2_HUMANETS2_HUMANIntAct32814053 details
TGFR2_HUMANPPARA_HUMANIntAct32814053 details
TGFR2_HUMANUBP25_HUMANIntAct32814053 details
TGFR2_HUMANUBP2_HUMANBioGRID29490279 details
TGFR2_HUMANKC1D_HUMANIntAct32814053 details
TGFR2_HUMANNSL1_HUMANIntAct32814053 details
TGFR2_HUMANATG13_HUMANIntAct32814053 details
TGFR2_HUMANAP1S1_HUMANIntAct32814053 details
TGFR2_HUMANPSMD2_HUMANIntAct32814053 details
TGFR2_HUMANTCOF_HUMANIntAct32814053 details
TGFR2_HUMANKLRG1_HUMANIntAct32814053 details
TGFR2_HUMANTYY1_HUMANIntAct32814053 details
TGFR2_HUMANNRP1_HUMANBioGRID20675371 21186301 details
TGFR2_HUMANKAD2_HUMANIntAct32814053 details
TGFR2_HUMANHD_HUMANIntAct32814053 details
TGFR2_HUMANPP2AB_HUMANBioGRID, MINT24412244 details
TGFR2_HUMANGPM6A_HUMANIntAct32814053 details
TGFR2_HUMANKELL_HUMANIntAct32814053 details
TGFR2_HUMANSTT3A_HUMANIntAct32814053 details
TGFR2_HUMANNELL2_HUMANIntAct32814053 details
TGFR2_HUMANSNX20_HUMANIntAct32814053 details
TGFR2_HUMANTERT_HUMANBioGRID23741361 details
TGFR2_HUMANAT2A3_HUMANIntAct32814053 details
TGFR2_HUMANGNAO_HUMANIntAct32814053 details
TGFR2_HUMANCA216_HUMANIntAct32814053 details
TGFR2_HUMANSNX6_HUMANBioGRID, HPRD11279102 details
TGFR2_HUMANP85A_HUMANBioGRID, HPRD, IntAct26186194 28514442 9435577 details
TGFR2_HUMANCDC42_HUMANBioGRID15761153 details
TGFR2_HUMANTRAF4_HUMANBioGRID23973329 details
TGFR2_HUMANPML_HUMANHPRD15356634 details
TGFR2_HUMANPP16B_HUMANBioGRID15761153 details
TGFR2_HUMANTSSK1_HUMANHPRD15761153 details
TGFR2_HUMANMED12_HUMANIntAct23178117 details
TGFR2_HUMANMARH7_HUMANBioGRID, IntAct26186194 28514442 29794480 details
TGFR2_HUMANACVL1_HUMANDIP, HPRD10716993 23868260 details
TGFR2_HUMANTGFB2_HUMANBioGRID, HPRD11157754 8106553 details
TGFR2_HUMANARHG6_HUMANBioGRID, HPRD15761153 details
TGFR2_HUMANCAV1_HUMANBioGRID30745168 details
TGFR2_HUMANSH3K1_HUMANBioGRID26169354 details
TGFR2_HUMANFAF1_HUMANBioGRID28443643 details
TGFR2_HUMANSMAD3_HUMANHPRD8774881 details
TGFR2_HUMANSMUF2_HUMANBioGRID11163210 25149540 details
TGFR2_HUMANT22D1_HUMANBioGRID21791611 details
TGFR2_HUMANM3K7_HUMANBioGRID19556242 details
TGFR2_HUMANOXSR1_HUMANBioGRID15761153 details
TGFR2_HUMANRASF1_HUMANBioGRID27292796 details
TGFR2_HUMANSMAD7_HUMANBioGRID, HPRD11163210 25149540 9335507 details
TGFR2_HUMANCTNB1_HUMANBioGRID, HPRD12000714 details
TGFR2_HUMANTGBR3_HUMANBioGRID, HPRD11323414 8106553 details
TGFR2_HUMANKCNKI_HUMANBioGRID, HPRD15761153 details
TGFR2_HUMANPEG10_HUMANBioGRID15611116 details
TGFR2_HUMANZFYV9_HUMANHPRD9865696 details
TGFR2_HUMANP85B_HUMANBioGRID, HPRD, IntAct26186194 28514442 9435577 details
TGFR2_HUMANIQGA1_HUMANBioGRID23454766 details
TGFR2_HUMANSMUF1_HUMANBioGRID11278251 27048878 details
TGFR2_HUMANCD44_HUMANHPRD12145287 details
TGFR2_HUMANEIF3I_HUMANBioGRID, HPRD11781097 7566156 9813058 details
TGFR2_HUMANTGFA1_HUMANBioGRID, HPRD11278302 details
TGFR2_HUMANCDK1_HUMANHPRD9926943 details
TGFR2_HUMANOCLN_HUMANBioGRID15761153 details
TGFR2_HUMANNRP2_HUMANBioGRID21186301 details
TGFR2_HUMANSMAD4_HUMANHPRD8774881 details
TGFR2_HUMANSHC1_HUMANMINT17440088 details
TGFR2_HUMANACE2_HUMANUniProt26867007 details
TGFR2_HUMANTERA_HUMANBioGRID28443643 details
TGFR2_HUMANTGFI1_HUMANHPRD12421567 details
TGFR2_HUMANFBW1A_HUMANBioGRID28443643 details
TGFR2_HUMANOSR1_HUMANHPRD15761153 details
TGFR2_HUMANTRAP1_HUMANHPRD11278302 details
TGFR2_HUMANFBX34_HUMANBioGRID15761153 details
TGFR2_HUMANSPSB1_HUMANBioGRID26032413 details
TGFR2_HUMANUFD1_HUMANBioGRID28443643 details
TGFR2_HUMANCUL1_HUMANBioGRID28443643 details
TGFR2_HUMANARHG7_HUMANHPRD15761153 details