Entity Details

Primary name FEN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP39748
EntryNameFEN1_HUMAN
FullNameFlap endonuclease 1
TaxID9606
Evidenceevidence at protein level
Length380
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesFEN1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000724 double-strand break repair via homologous recombination
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0004527 exonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006287 base-excision repair, gap-filling
GO:0006302 double-strand break repair
GO:0007613 memory
GO:0008309 double-stranded DNA exodeoxyribonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0009650 UV protection
GO:0016020 membrane
GO:0017108 5'-flap endonuclease activity
GO:0030145 manganese ion binding
GO:0032201 telomere maintenance via semi-conservative replication
GO:0032991 protein-containing complex
GO:0043137 DNA replication, removal of RNA primer
GO:0045876 positive regulation of sister chromatid cohesion
GO:0048256 flap endonuclease activity
GO:0090305 nucleic acid phosphodiester bond hydrolysis

Subcellular Location

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Subcellular Location
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR006084 XPG/Rad2 endonucleaseFamilyFamily
IPR006085 XPG, N-terminalDomainDomain
IPR006086 XPG-I domainDomainDomain
IPR008918 Helix-hairpin-helix motif, class 2SiteConserved site
IPR019974 XPG conserved siteSiteConserved site
IPR023426 Flap endonuclease 1FamilyFamily
IPR029060 PIN-like domain superfamilyFamilyHomologous superfamily
IPR036279 5'-3' exonuclease, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01592 IronDrugbanksmall molecule
DB14488 Ferrous gluconateDrugbanksmall molecule
DB14489 Ferrous succinateDrugbanksmall molecule
DB14490 Ferrous ascorbateDrugbanksmall molecule
DB14491 Ferrous fumarateDrugbanksmall molecule
DB14501 Ferrous glycine sulfateDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
FEN1_HUMANGDIR1_HUMANBioGRID, HPRD, IntAct16169070 details
FEN1_HUMANEF1G_HUMANBioGRID, HPRD, IntAct16169070 details
FEN1_HUMANWRN_HUMANBioGRID, HPRD, IntAct11598021 12356323 14657243 14688284 16326861 details
FEN1_HUMANBLM_HUMANBioGRID, HPRD, IntAct14688284 16326861 details
FEN1_HUMANPCNA_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11313979 11430825 11601988 12853968 14657243 1477073 15576034 15616578 16216273 17115032 18692475 22556262 22592530 22606318 24728180 24958773 26030842 26186194 26264872 26496610 26751069 28514442 29997244 30184152 31467278 31515488 32900933 7673186 8668533 8876181 9178907 9305916 9545252 details
FEN1_HUMANGSK3B_HUMANBioGRID, MINT21900206 details
FEN1_HUMANTERF2_HUMANbhf-ucl21044950 details
FEN1_HUMANWDR4_HUMANBioGRID, DIP26751069 details
FEN1_HUMANROA1_HUMANBioGRID, HPRD14690413 details
FEN1_HUMANCDK2_HUMANBioGRID, HPRD12853968 details
FEN1_HUMANCCNA2_HUMANBioGRID12853968 details
FEN1_HUMANCDK1_HUMANBioGRID, HPRD12853968 details
FEN1_HUMANEP300_HUMANBioGRID, HPRD11430825 16326861 20019387 details
FEN1_HUMANAPEX1_HUMANBioGRID, HPRD11601988 details
FEN1_HUMANHUS1_HUMANBioGRID16216273 19535328 30184152 details
FEN1_HUMANRAD9A_HUMANBioGRID16216273 19535328 details
FEN1_HUMANRAD1_HUMANBioGRID15556996 16216273 19535328 30184152 details
FEN1_HUMANTERF1_HUMANBioGRID21044950 details
FEN1_HUMANA4_HUMANBioGRID21832049 details
FEN1_HUMANOGT1_HUMANBioGRID32994395 details
FEN1_HUMANMUS81_HUMANMINT22551069 details
FEN1_HUMANCND3_HUMANBioGRID16543152 details
FEN1_HUMANDDX11_HUMANBioGRID18499658 details
FEN1_HUMANNUCG_HUMANBioGRID16133872 details
FEN1_HUMANAICDA_HUMANBioGRID23277564 details
FEN1_HUMANSEM1_HUMANBioGRID24515614 details
FEN1_HUMANSEML_HUMANBioGRID24515614 details
FEN1_HUMANDNA2_HUMANBioGRID20019387 details