Entity Details

Primary name ECHA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40939
EntryNameECHA_HUMAN
FullNameTrifunctional enzyme subunit alpha, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length763
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesHADHA

GO terms

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GOName
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0006635 fatty acid beta-oxidation
GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0035965 cardiolipin acyl-chain remodeling
GO:0042645 mitochondrial nucleoid
GO:0070403 NAD+ binding

Subcellular Location

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Subcellular Location
Mitochondrion
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR001753 Enoyl-CoA hydratase/isomeraseFamilyFamily
IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminalDomainDomain
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD bindingDomainDomain
IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved siteSiteConserved site
IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR012803 Fatty acid oxidation complex, alpha subunit, mitochondrialFamilyFamily
IPR018376 Enoyl-CoA hydratase/isomerase, conserved siteSiteConserved site
IPR029045 ClpP/crotonase-like domain superfamilyFamilyHomologous superfamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
ECHA_HUMANGBRAP_HUMANIntAct20562859 details
ECHA_HUMANMLP3B_HUMANBioGRID, IntAct20562859 details
ECHA_HUMANHG2A_HUMANBioGRID, IntAct21988832 30833792 details
ECHA_HUMANNR4A1_HUMANBioGRID, IntAct21988832 details
ECHA_HUMANABCF2_HUMANBioGRID, IntAct21988832 details
ECHA_HUMANATX2L_HUMANBioGRID, IntAct21988832 details
ECHA_HUMANECHB_HUMANBioGRID, IntAct, UniProt22939629 24981860 26344197 28514442 29915090 31536960 details
ECHA_HUMANHD_HUMANIntAct32814053 details
ECHA_HUMAN1433T_HUMANBioGRID15161933 details
ECHA_HUMANPIN1_HUMANBioGRID16055720 details
ECHA_HUMANHCD2_HUMANBioGRID22496890 details
ECHA_HUMANPTEN_HUMANBioGRID31685992 details
ECHA_HUMANM3K1_HUMANIntAct14743216 details
ECHA_HUMANNFKB2_HUMANIntAct14743216 details
ECHA_HUMANRIPK3_HUMANIntAct14743216 details
ECHA_HUMANTNR1A_HUMANIntAct14743216 details
ECHA_HUMANTRAF6_HUMANIntAct14743216 17353931 details
ECHA_HUMANEPB41_HUMANIntAct17353931 details
ECHA_HUMANAAKB1_HUMANIntAct17353931 details
ECHA_HUMANBCAR3_HUMANIntAct17353931 details
ECHA_HUMANHLAB_HUMANIntAct17353931 details
ECHA_HUMANIKKE_HUMANIntAct17353931 details
ECHA_HUMANSQSTM_HUMANBioGRID, IntAct20562859 26043024 details
ECHA_HUMANPSMD4_HUMANBioGRID12601813 details
ECHA_HUMANHDAC5_HUMANBioGRID21081666 details
ECHA_HUMANLEO1_HUMANBioGRID20305087 details
ECHA_HUMANRTF1_HUMANBioGRID20305087 details
ECHA_HUMANCAH9_HUMANBioGRID23181366 details
ECHA_HUMANZBTB1_HUMANBioGRID24657165 details
ECHA_HUMANGRSF1_HUMANBioGRID23473034 29395067 details
ECHA_HUMANAKTIP_HUMANBioGRID27512140 details
ECHA_HUMANCETN3_HUMANBioGRID30251372 details
ECHA_HUMANFGF11_HUMANBioGRID28027390 details