Entity Details

Primary name OPRX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41146
EntryNameOPRX_HUMAN
FullNameNociceptin receptor
TaxID9606
Evidenceevidence at protein level
Length370
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesOPRL1

GO terms

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GOName
GO:0001626 nociceptin receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007600 sensory perception
GO:0007610 behavior
GO:0019233 sensory perception of pain
GO:0031410 cytoplasmic vesicle
GO:0038003 G protein-coupled opioid receptor signaling pathway
GO:0042277 peptide binding
GO:0042923 neuropeptide binding
GO:0043005 neuron projection
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001418 Opioid receptorFamilyFamily
IPR001420 X opioid receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00921 BuprenorphineDrugbanksmall molecule
DB01497 EtorphineDrugbanksmall molecule
DB05492 Epicept NP-1Drugbanksmall molecule