Entity Details

Primary name LEP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41159
EntryNameLEP_HUMAN
FullNameLeptin
TaxID9606
Evidenceevidence at protein level
Length167
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesLEP

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001525 angiogenesis
GO:0001542 ovulation from ovarian follicle
GO:0001666 response to hypoxia
GO:0001890 placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0001936 regulation of endothelial cell proliferation
GO:0002021 response to dietary excess
GO:0003300 cardiac muscle hypertrophy
GO:0003677 DNA binding
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006112 energy reserve metabolic process
GO:0006114 glycerol biosynthetic process
GO:0006629 lipid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006909 phagocytosis
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007565 female pregnancy
GO:0007623 circadian rhythm
GO:0008203 cholesterol metabolic process
GO:0008206 bile acid metabolic process
GO:0008217 regulation of blood pressure
GO:0008340 determination of adult lifespan
GO:0008343 adult feeding behavior
GO:0010507 negative regulation of autophagy
GO:0010888 negative regulation of lipid storage
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0019953 sexual reproduction
GO:0021954 central nervous system neuron development
GO:0030073 insulin secretion
GO:0030217 T cell differentiation
GO:0030300 regulation of intestinal cholesterol absorption
GO:0032008 positive regulation of TOR signaling
GO:0032099 negative regulation of appetite
GO:0032310 prostaglandin secretion
GO:0032355 response to estradiol
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032814 regulation of natural killer cell activation
GO:0032817 regulation of natural killer cell proliferation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033197 response to vitamin E
GO:0033210 leptin-mediated signaling pathway
GO:0033686 positive regulation of luteinizing hormone secretion
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0035630 bone mineralization involved in bone maturation
GO:0035904 aorta development
GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042269 regulation of natural killer cell mediated cytotoxicity
GO:0042307 positive regulation of protein import into nucleus
GO:0042445 hormone metabolic process
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0044320 cellular response to leptin stimulus
GO:0045471 response to ethanol
GO:0045765 regulation of angiogenesis
GO:0045906 negative regulation of vasoconstriction
GO:0046325 negative regulation of glucose import
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046850 regulation of bone remodeling
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0048639 positive regulation of developmental growth
GO:0050796 regulation of insulin secretion
GO:0050810 regulation of steroid biosynthetic process
GO:0050892 intestinal absorption
GO:0050901 leukocyte tethering or rolling
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051428 peptide hormone receptor binding
GO:0051541 elastin metabolic process
GO:0051726 regulation of cell cycle
GO:0051897 positive regulation of protein kinase B signaling
GO:0060587 regulation of lipoprotein lipid oxidation
GO:0060612 adipose tissue development
GO:0061037 negative regulation of cartilage development
GO:0070093 negative regulation of glucagon secretion
GO:0071298 cellular response to L-ascorbic acid
GO:0071300 cellular response to retinoic acid
GO:0090335 regulation of brown fat cell differentiation
GO:0098868 bone growth
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1900745 positive regulation of p38MAPK cascade
GO:1904651 positive regulation of fat cell apoptotic process
GO:1990051 activation of protein kinase C activity
GO:1990460 leptin receptor binding
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000486 negative regulation of glutamine transport
GO:2000491 positive regulation of hepatic stellate cell activation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000065 LeptinFamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614962 OMIMLeptin deficiency (LEPD)A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age. The disease is caused by variants affecting the gene represented in this entry.