Entity Details

Primary name CASP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42574
EntryNameCASP3_HUMAN
FullNameCaspase-3
TaxID9606
Evidenceevidence at protein level
Length277
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesCASP3

GO terms

Show/Hide Table
GOName
GO:0021766 hippocampus development
GO:0001666 response to hypoxia
GO:0005737 cytoplasm
GO:0006508 proteolysis
GO:0030216 keratinocyte differentiation
GO:0043525 positive regulation of neuron apoptotic process
GO:0030218 erythrocyte differentiation
GO:0042542 response to hydrogen peroxide
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0072734 cellular response to staurosporine
GO:0005654 nucleoplasm
GO:0007413 axonal fasciculation
GO:0071887 leukocyte apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0009411 response to UV
GO:0031647 regulation of protein stability
GO:0043025 neuronal cell body
GO:1902004 positive regulation of amyloid-beta formation
GO:0002020 protease binding
GO:0005123 death receptor binding
GO:0042493 response to drug
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0030220 platelet formation
GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0016241 regulation of macroautophagy
GO:0045165 cell fate commitment
GO:0006309 apoptotic DNA fragmentation
GO:0034349 glial cell apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0008233 peptidase activity
GO:0046007 negative regulation of activated T cell proliferation
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0032355 response to estradiol
GO:0042060 wound healing
GO:0051146 striated muscle cell differentiation
GO:0004190 aspartic-type endopeptidase activity
GO:0007611 learning or memory
GO:0010165 response to X-ray
GO:0031264 death-inducing signaling complex
GO:0043200 response to amino acid
GO:0001782 B cell homeostasis
GO:0016485 protein processing
GO:0019221 cytokine-mediated signaling pathway
GO:0030182 neuron differentiation
GO:0044877 protein-containing complex binding
GO:0051402 neuron apoptotic process
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0006915 apoptotic process
GO:0043029 T cell homeostasis
GO:0045121 membrane raft
GO:0007605 sensory perception of sound
GO:0035329 hippo signaling
GO:0007507 heart development
GO:0030889 negative regulation of B cell proliferation
GO:0032025 response to cobalt ion
GO:0046677 response to antibiotic
GO:0097190 apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0001554 luteolysis
GO:0004197 cysteine-type endopeptidase activity
GO:0005829 cytosol
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 nucleus
GO:0009749 response to glucose
GO:0032496 response to lipopolysaccharide
GO:0035094 response to nicotine
GO:0043065 positive regulation of apoptotic process
GO:0051384 response to glucocorticoid
GO:0061713 anterior neural tube closure
GO:0034612 response to tumor necrosis factor
GO:0016005 phospholipase A2 activator activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR015471 Caspase-3/7FamilyFamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00282 Pamidronic acidDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB03124 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic AcidDrugbanksmall molecule
DB05408 EmricasanDrugbanksmall molecule
DB06255 Incadronic acidDrugbanksmall molecule
DB06862 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACIDDrugbanksmall molecule
DB07696 methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoateDrugbanksmall molecule
DB08213 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONEDrugbanksmall molecule
DB08229 [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acidDrugbanksmall molecule
DB08251 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACIDDrugbanksmall molecule
DB08497 (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetateDrugbanksmall molecule
DB08498 (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetateDrugbanksmall molecule
DB08499 N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamideDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule

Interactions

178 interactions

InteractorPartnerSourcesPublicationsLink
CASP3_HUMANXIAP_HUMANBioGRID, DIP, HPRD, IntAct, MINT11257230 11257232 11359776 11447297 11927604 12624662 15200957 15507451 15650747 16543147 16869888 17069460 17291493 18521960 18723680 19273858 19698783 22072751 22815893 23074197 23979166 25241761 26186194 27927753 28514442 30522111 9230442 9384571 9525868 details
CASP3_HUMANCASP9_HUMANBioGRID, DIP, HPRD, IntAct, MINT1067155 11230124 11242052 15507451 15941357 17437405 18723680 25241761 8900201 details
CASP3_HUMANAPAF_HUMANHPRD, IntAct, MINT11550094 21827945 details
CASP3_HUMAN1433E_HUMANHPRD, MINT12657644 details
CASP3_HUMANBIRC2_HUMANBioGRID, HPRD, IntAct11084335 11106668 17069460 19258326 9384571 details
CASP3_HUMANBIRC7_HUMANBioGRID, HPRD, IntAct11024045 11084335 23563149 details
CASP3_HUMANNMT2_HUMANHPRD, IntAct, MINT16530191 23150525 details
CASP3_HUMANWNK3_HUMANIntAct16501604 details
CASP3_HUMANAKT1_HUMANHPRD, MINT12124386 17544405 details
CASP3_HUMANAKT2_HUMANMINT17544405 details
CASP3_HUMANAKT3_HUMANBioGRID, IntAct, MINT17544405 25241761 details
CASP3_HUMANNUCB2_HUMANMINT18154733 details
CASP3_HUMANGLRX1_HUMANBioGRID, IntAct21988832 details
CASP3_HUMAN1433G_HUMANBioGRID, IntAct21988832 details
CASP3_HUMANSOCS5_HUMANBioGRID, IntAct21988832 details
CASP3_HUMANRET_HUMANIntAct10921886 details
CASP3_HUMANGATA1_HUMANBioGRID, DIP, HPRD17167422 details
CASP3_HUMANPARP1_HUMANBioGRID, DIP17167422 18723680 19549685 19713971 22451931 32223133 7596430 8642305 9875225 details
CASP3_HUMANMDM2_HUMANBioGRID, HPRD, IntAct21726810 24842904 25241761 9278461 9840926 details
CASP3_HUMANCALB1_HUMANMINT22982862 details
CASP3_HUMANA4_HUMANBioGRID, HPRD, IntAct15178331 25241761 32814053 8943232 details
CASP3_HUMANDFFA_HUMANBioGRID, HPRD, IntAct11752060 18723680 25241761 9108473 details
CASP3_HUMANCASP6_HUMANBioGRID, DIP, HPRD, IntAct18723680 25241761 8900201 details
CASP3_HUMANCDN1A_HUMANBioGRID, HPRD, IntAct10022118 25241761 30320919 9660939 9799125 details
CASP3_HUMANSRC8_HUMANBioGRID, IntAct11689006 25241761 details
CASP3_HUMANHCLS1_HUMANBioGRID, HPRD, IntAct11689006 11988074 25241761 details
CASP3_HUMANA16L1_HUMANIntAct24553140 details
CASP3_HUMANAKAP8_HUMANHPRD, UniProt16227597 details
CASP3_HUMANSOLH1_HUMANBioGRID, IntAct32296183 details
CASP3_HUMANTHIO_HUMANDIP17606900 details
CASP3_HUMANCRYAB_HUMANBioGRID, DIP18669646 23049853 23074197 details
CASP3_HUMANCASP8_HUMANBioGRID, DIP, HPRD11437602 11832478 15254227 18669646 8962078 details
CASP3_HUMANBID_HUMANBioGRID, DIP, HPRD10364179 11399776 18723680 details
CASP3_HUMANGDIR2_HUMANDIP, HPRD18723680 8626669 details
CASP3_HUMANTEBP_HUMANBioGRID, DIP18723680 22451931 details
CASP3_HUMANOSTP_HUMANDIP19706414 details
CASP3_HUMANPANX1_HUMANDIP20944749 32494015 details
CASP3_HUMANNMT1_HUMANIntAct23150525 details
CASP3_HUMANDCTN1_HUMANHPRD, IntAct11425872 32814053 details
CASP3_HUMANHD_HUMANHPRD, IntAct10770929 32814053 details
CASP3_HUMANATX3_HUMANIntAct32814053 details
CASP3_HUMANBCL2_HUMANBioGRID, HPRD11752215 11948397 9395403 details
CASP3_HUMANBLM_HUMANBioGRID, HPRD11470874 details
CASP3_HUMANMCL1_HUMANBioGRID, HPRD15637055 details
CASP3_HUMANTRAF3_HUMANBioGRID, HPRD11098060 11261798 details
CASP3_HUMANCFLAR_HUMANBioGRID, HPRD9208847 9326610 details
CASP3_HUMANDCC_HUMANBioGRID, HPRD11248093 details
CASP3_HUMANCASP2_HUMANBioGRID11399776 18723680 details
CASP3_HUMANPARG_HUMANBioGRID, HPRD11053413 details
CASP3_HUMANGORS1_HUMANBioGRID, HPRD11815631 details
CASP3_HUMANSRBP2_HUMANBioGRID, HPRD8605870 details
CASP3_HUMANBIRC5_HUMANBioGRID, HPRD11170436 9850056 details
CASP3_HUMANDBNL_HUMANBioGRID11689006 details
CASP3_HUMANBMX_HUMANBioGRID, HPRD11278797 details
CASP3_HUMANUSO1_HUMANBioGRID, HPRD12438416 details
CASP3_HUMANBIRC3_HUMANBioGRID, HPRD17069460 9384571 details
CASP3_HUMANCASPA_HUMANBioGRID, HPRD8755496 8962078 details
CASP3_HUMANGRAP1_HUMANBioGRID, HPRD10896157 12207967 details
CASP3_HUMANNDUS1_HUMANBioGRID15186778 details
CASP3_HUMANRING2_HUMANBioGRID17379327 details
CASP3_HUMANGEMI_HUMANBioGRID17261582 details
CASP3_HUMANTHA11_HUMANBioGRID, HPRD18585351 details
CASP3_HUMANMDC1_HUMANBioGRID21148072 details
CASP3_HUMANBIRC6_HUMANBioGRID, HPRD15200957 15507451 details
CASP3_HUMANCSN6_HUMANBioGRID17337451 details
CASP3_HUMANZBT16_HUMANBioGRID17340613 details
CASP3_HUMANPKN1_HUMANBioGRID, HPRD9751706 details
CASP3_HUMANSP1_HUMANBioGRID, HPRD10103059 details
CASP3_HUMANMK08_HUMANBioGRID12821118 details
CASP3_HUMANMK09_HUMANBioGRID12821118 details
CASP3_HUMANRB_HUMANBioGRID, HPRD11420704 15735701 details
CASP3_HUMANPRKDC_HUMANBioGRID, HPRD8642305 8804412 details
CASP3_HUMANPA24B_HUMANBioGRID9875225 details
CASP3_HUMANGRAB_HUMANBioGRID, HPRD17008916 17283187 9233763 9694885 details
CASP3_HUMANTNF10_HUMANBioGRID23703388 details
CASP3_HUMANGELS_HUMANBioGRID, HPRD18723680 9323209 9671712 details
CASP3_HUMANGDIR1_HUMANBioGRID18723680 details
CASP3_HUMANVIME_HUMANBioGRID, HPRD10469173 11423904 11514563 18723680 details
CASP3_HUMANSPTN1_HUMANBioGRID, HPRD18723680 9811849 details
CASP3_HUMANSTAT1_HUMANBioGRID18723680 details
CASP3_HUMANROCK1_HUMANBioGRID, HPRD11283607 18723680 details
CASP3_HUMANCASP7_HUMANBioGRID18723680 details
CASP3_HUMANBECN1_HUMANBioGRID19713971 details
CASP3_HUMANATG4D_HUMANBioGRID19549685 details
CASP3_HUMANARNT_HUMANBioGRID11593383 details
CASP3_HUMANTAU_HUMANBioGRID, HPRD11162250 12888622 16606369 22535953 details
CASP3_HUMANRU17_HUMANBioGRID8642305 details
CASP3_HUMANFETA_HUMANBioGRID31811908 details
CASP3_HUMANNF2L2_HUMANHPRD10510468 details
CASP3_HUMANPSME3_HUMANHPRD11859414 details
CASP3_HUMANSTK3_HUMANBioGRID, HPRD, IntAct11278283 25241761 details
CASP3_HUMANPAK2_HUMANBioGRID, HPRD, IntAct16204230 25241761 9786869 details
CASP3_HUMANTRAF1_HUMANBioGRID, HPRD, IntAct11098060 25241761 details
CASP3_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct25241761 9348292 details
CASP3_HUMANRAD51_HUMANBioGRID, HPRD, IntAct10082566 10998058 25241761 details
CASP3_HUMANMLH1_HUMANBioGRID, HPRD, IntAct15087450 25241761 details
CASP3_HUMANMET_HUMANBioGRID, HPRD, IntAct15542841 25241761 details
CASP3_HUMANCDC42_HUMANBioGRID, HPRD, IntAct11278572 25241761 details
CASP3_HUMANSTK4_HUMANBioGRID, HPRD, IntAct11278283 11278782 25241761 9545236 details
CASP3_HUMANCH60_HUMANBioGRID, HPRD10205158 10205159 details
CASP3_HUMANCH10_HUMANBioGRID, HPRD10205158 details
CASP3_HUMANHEY2_HUMANBioGRID17217622 details
CASP3_HUMANRBX1_HUMANBioGRID17217622 details
CASP3_HUMANFBW1B_HUMANBioGRID17217622 details
CASP3_HUMANFBW1A_HUMANBioGRID17217622 details
CASP3_HUMANHSPB1_HUMANBioGRID22238643 details
CASP3_HUMANBAX_HUMANBioGRID15254227 details
CASP3_HUMANMK14_HUMANBioGRID14970175 details
CASP3_HUMANP53_HUMANBioGRID21307660 details
CASP3_HUMANTRAF2_HUMANBioGRID30054040 details
CASP3_HUMANSKP2_HUMANBioGRID31181401 details
CASP3_HUMANLYN_HUMANHPRD11526478 details
CASP3_HUMANDSG3_HUMANHPRD11500511 details
CASP3_HUMANAP2A_HUMANHPRD11438643 details
CASP3_HUMANE2AK2_HUMANHPRD11555640 details
CASP3_HUMANKPCZ_HUMANHPRD11016947 details
CASP3_HUMANPTMA_HUMANHPRD10675528 9334214 details
CASP3_HUMANTGM2_HUMANHPRD10556977 details
CASP3_HUMANBAP31_HUMANHPRD9334338 details
CASP3_HUMANKPCT_HUMANHPRD9252332 details
CASP3_HUMANSRF_HUMANHPRD11387340 details
CASP3_HUMANMEF2A_HUMANHPRD11904443 details
CASP3_HUMANPTBP1_HUMANHPRD12004072 details
CASP3_HUMANPSN2_HUMANHPRD10069390 9219695 9990034 details
CASP3_HUMANIL18_HUMANHPRD9334240 details
CASP3_HUMANM4K1_HUMANHPRD10602493 details
CASP3_HUMANSRP72_HUMANHPRD9857079 details
CASP3_HUMANNEDD4_HUMANHPRD9593687 details
CASP3_HUMANPAXI_HUMANHPRD11825902 details
CASP3_HUMANPKN2_HUMANHPRD9368003 details
CASP3_HUMANGOGA3_HUMANHPRD10791974 details
CASP3_HUMANCASP4_HUMANHPRD9233763 9694885 details
CASP3_HUMANMDM4_HUMANHPRD11840332 details
CASP3_HUMANHNRPU_HUMANHPRD10671544 details
CASP3_HUMANBCAR1_HUMANHPRD10712510 details
CASP3_HUMANPICAL_HUMANHPRD10926122 details
CASP3_HUMANIL16_HUMANHPRD10479680 9422780 details
CASP3_HUMANPI51A_HUMANHPRD11042212 details
CASP3_HUMANPDE5A_HUMANHPRD11602184 details
CASP3_HUMANRABE1_HUMANHPRD10608812 details
CASP3_HUMANPSIP1_HUMANHPRD12181742 details
CASP3_HUMANIF2A_HUMANHPRD10432301 10734073 details
CASP3_HUMANEIF3J_HUMANHPRD10672017 details
CASP3_HUMANIF4B_HUMANHPRD10672017 11274152 details
CASP3_HUMANACINU_HUMANHPRD10490026 details
CASP3_HUMANCSEN_HUMANHPRD11278424 details
CASP3_HUMANDEDD_HUMANHPRD12235123 details
CASP3_HUMANATN1_HUMANHPRD9361003 details
CASP3_HUMANPYR1_HUMANHPRD11854437 details
CASP3_HUMANSTK24_HUMANHPRD12107159 details
CASP3_HUMANSLK_HUMANHPRD10611247 details
CASP3_HUMANUBE4B_HUMANHPRD11802788 details
CASP3_HUMANJIP3_HUMANHPRD10629060 details
CASP3_HUMANSYSM_HUMANHPRD11331419 details
CASP3_HUMANPDE10_HUMANHPRD11602184 details
CASP3_HUMANICAL_HUMANHPRD9705209 details
CASP3_HUMANPA24A_HUMANHPRD9875225 details
CASP3_HUMANIF4G2_HUMANHPRD11175261 details
CASP3_HUMANVAV_HUMANHPRD10713703 details
CASP3_HUMANBRCA1_HUMANHPRD12149654 details
CASP3_HUMANPP2BA_HUMANHPRD11478781 details
CASP3_HUMANRFC1_HUMANHPRD9235961 9351817 details
CASP3_HUMANCDC27_HUMANHPRD9618490 details
CASP3_HUMANWEE1_HUMANHPRD9618490 details
CASP3_HUMANAIFM1_HUMANHPRD9206994 details
CASP3_HUMANANDR_HUMANHPRD8626669 9208847 9535906 details
CASP3_HUMANRAC1_HUMANHPRD11278572 details
CASP3_HUMANCD11B_HUMANHPRD9632733 details
CASP3_HUMANK1C18_HUMANHPRD11356849 12235123 9298992 details
CASP3_HUMANTOP1_HUMANHPRD9933635 details
CASP3_HUMANHIP1_HUMANHPRD16979168 details
CASP3_HUMANADDA_HUMANHPRD10823823 details
CASP3_HUMANFYN_HUMANHPRD10435619 details
CASP3_HUMANRASA1_HUMANHPRD10200531 details
CASP3_HUMANPSN1_HUMANHPRD10069390 details
CASP3_HUMANLMNB1_HUMANHPRD11901153 details
CASP3_HUMANMYL3_HUMANHPRD12186978 details
CASP3_HUMANHMGB1_HUMANHPRD11748221 details