Entity Details

Primary name GDF5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43026
EntryNameGDF5_HUMAN
FullNameGrowth/differentiation factor 5
TaxID9606
Evidenceevidence at protein level
Length501
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesGDF5

GO terms

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GOName
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0009612 response to mechanical stimulus
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030326 embryonic limb morphogenesis
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0036122 BMP binding
GO:0040014 regulation of multicellular organism growth
GO:0042802 identical protein binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043932 ossification involved in bone remodeling
GO:0045666 positive regulation of neuron differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060390 regulation of SMAD protein signal transduction
GO:0060395 SMAD protein signal transduction
GO:0060591 chondroblast differentiation
GO:2001054 negative regulation of mesenchymal cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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