Entity Details

Primary name NR4A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43354
EntryNameNR4A2_HUMAN
FullNameNuclear receptor subfamily 4 group A member 2
TaxID9606
Evidenceevidence at protein level
Length598
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesNR4A2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0001764 neuron migration
GO:0001975 response to amphetamine
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0008013 beta-catenin binding
GO:0008270 zinc ion binding
GO:0008344 adult locomotory behavior
GO:0009791 post-embryonic development
GO:0016607 nuclear speck
GO:0021952 central nervous system projection neuron axonogenesis
GO:0021953 central nervous system neuron differentiation
GO:0021986 habenula development
GO:0031668 cellular response to extracellular stimulus
GO:0032991 protein-containing complex
GO:0034599 cellular response to oxidative stress
GO:0035259 glucocorticoid receptor binding
GO:0042053 regulation of dopamine metabolic process
GO:0042416 dopamine biosynthetic process
GO:0042551 neuron maturation
GO:0043085 positive regulation of catalytic activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043576 regulation of respiratory gaseous exchange
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046965 retinoid X receptor binding
GO:0046982 protein heterodimerization activity
GO:0051866 general adaptation syndrome
GO:0060070 canonical Wnt signaling pathway
GO:0071376 cellular response to corticotropin-releasing hormone stimulus
GO:0071542 dopaminergic neuron differentiation
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1990837 sequence-specific double-stranded DNA binding
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003070 Orphan nuclear receptorFamilyFamily
IPR003073 Orphan nuclear receptor, NURR typeFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
NR4A2_HUMANTCAL5_HUMANBioGRID, IntAct20195357 details
NR4A2_HUMANBAZ1B_HUMANBioGRID, IntAct20195357 details
NR4A2_HUMANCDN2D_HUMANBioGRID, IntAct25416956 31515488 32296183 details
NR4A2_HUMANODAD2_HUMANBioGRID, IntAct32296183 details
NR4A2_HUMANA4_HUMANIntAct32814053 details
NR4A2_HUMANRXRB_HUMANBioGRID, HPRD, IntAct15604093 20211142 7705655 7758108 details
NR4A2_HUMANSMCA4_HUMANBioGRID17043312 details
NR4A2_HUMANSMCA2_HUMANBioGRID17043312 details
NR4A2_HUMANRXRA_HUMANBioGRID, HPRD15604093 7705655 7758108 details
NR4A2_HUMANCSN5_HUMANBioGRID, HPRD15604093 details
NR4A2_HUMANPPARG_HUMANBioGRID11877444 details
NR4A2_HUMANMK01_HUMANBioGRID17681692 details
NR4A2_HUMANPIAS4_HUMANHPRD14559918 details
NR4A2_HUMANGTF2I_HUMANIntAct20195357 details
NR4A2_HUMANCISD1_HUMANIntAct20195357 details
NR4A2_HUMANRAN_HUMANIntAct20195357 details
NR4A2_HUMANNO40_HUMANIntAct20195357 details
NR4A2_HUMANZNF41_HUMANIntAct20195357 details
NR4A2_HUMANOPA1_HUMANIntAct20195357 details
NR4A2_HUMANNDUS5_HUMANIntAct20195357 details
NR4A2_HUMANAN32E_HUMANIntAct20195357 details
NR4A2_HUMANNFM_HUMANIntAct20195357 details
NR4A2_HUMANEIF3A_HUMANIntAct20195357 details
NR4A2_HUMANSUGP2_HUMANIntAct20195357 details
NR4A2_HUMANADX_HUMANIntAct20195357 details
NR4A2_HUMANSFPQ_HUMANBioGRID19144721 details
NR4A2_HUMANNCOR2_HUMANBioGRID19144721 details
NR4A2_HUMANSIN3A_HUMANBioGRID19144721 details
NR4A2_HUMANRUNX1_HUMANBioGRID21468021 details
NR4A2_HUMANNCOA1_HUMANBioGRID21757690 details
NR4A2_HUMANPRGC1_HUMANBioGRID21757690 details
NR4A2_HUMANMK03_HUMANBioGRID17681692 details
NR4A2_HUMANCDN1C_HUMANHPRD14671317 details
NR4A2_HUMANKS6A1_HUMANHPRD16223362 details
NR4A2_HUMANVHL_HUMANHPRD18305400 details