Entity Details

Primary name NKX21_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43699
EntryNameNKX21_HUMAN
FullNameHomeobox protein Nkx-2.1
TaxID9606
Evidenceevidence at protein level
Length371
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesNKX2-1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001161 intronic transcription regulatory region sequence-specific DNA binding
GO:0001764 neuron migration
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006644 phospholipid metabolic process
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007492 endoderm development
GO:0007626 locomotory behavior
GO:0008134 transcription factor binding
GO:0009725 response to hormone
GO:0010628 positive regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0019899 enzyme binding
GO:0021759 globus pallidus development
GO:0021766 hippocampus development
GO:0021795 cerebral cortex cell migration
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021877 forebrain neuron fate commitment
GO:0021892 cerebral cortex GABAergic interneuron differentiation
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0030336 negative regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030878 thyroid gland development
GO:0030900 forebrain development
GO:0031128 developmental induction
GO:0033327 Leydig cell differentiation
GO:0042753 positive regulation of circadian rhythm
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048709 oligodendrocyte differentiation
GO:0060430 lung saccule development
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060486 club cell differentiation
GO:0060510 type II pneumocyte differentiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain

Diseases

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Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
NKX21_HUMANTAP26_HUMANUniProt11152647 details
NKX21_HUMANABL1_HUMANIntAct17474147 details
NKX21_HUMANCRK_HUMANIntAct17474147 details
NKX21_HUMANSRC_HUMANIntAct17474147 details
NKX21_HUMANFYN_HUMANIntAct17474147 details
NKX21_HUMANGRB2_HUMANIntAct17474147 details
NKX21_HUMANNCK1_HUMANIntAct17474147 details
NKX21_HUMANSMAD3_HUMANIntAct18003659 details
NKX21_HUMANFOXA1_HUMANBioGRID, IntAct17220277 18003659 28192407 details
NKX21_HUMANRARA_HUMANBioGRID, HPRD10617585 11274148 details
NKX21_HUMANNCOA2_HUMANBioGRID, HPRD10617585 details
NKX21_HUMANHIPK2_HUMANBioGRID, HPRD11438542 details
NKX21_HUMANCAVN1_HUMANBioGRID9582279 details
NKX21_HUMANNCOA3_HUMANBioGRID11076796 15449938 details
NKX21_HUMANCBP_HUMANBioGRID, HPRD11076796 11713256 15449938 details
NKX21_HUMANPAX8_HUMANBioGRID, HPRD12441357 14970209 details
NKX21_HUMANCALR_HUMANBioGRID, HPRD9988700 details
NKX21_HUMANNCOA1_HUMANBioGRID, HPRD11076796 11713256 15449938 details
NKX21_HUMANTDG_HUMANHPRD11438542 details
NKX21_HUMANGATA6_HUMANHPRD11733512 details
NKX21_HUMANTF65_HUMANBioGRID, HPRD12040027 details
NKX21_HUMANDDB1_HUMANBioGRID28192407 details
NKX21_HUMANHXB5_HUMANBioGRID21677782 details
NKX21_HUMANPARP1_HUMANBioGRID28192407 details
NKX21_HUMANPCNA_HUMANBioGRID28192407 details
NKX21_HUMANPRKDC_HUMANBioGRID28192407 details
NKX21_HUMANRFA2_HUMANBioGRID28192407 details
NKX21_HUMANWRN_HUMANBioGRID28192407 details
NKX21_HUMANXRCC5_HUMANBioGRID28192407 details
NKX21_HUMANFOXA2_HUMANBioGRID17220277 details
NKX21_HUMANMK01_HUMANHPRD10733581 details
NKX21_HUMANWWTR1_HUMANHPRD14970209 details