Entity Details

Primary name GLRB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48167
EntryNameGLRB_HUMAN
FullNameGlycine receptor subunit beta
TaxID9606
Evidenceevidence at protein level
Length497
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesGLRB

GO terms

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GOName
GO:0001964 startle response
GO:0004888 transmembrane signaling receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007340 acrosome reaction
GO:0007399 nervous system development
GO:0007601 visual perception
GO:0007628 adult walking behavior
GO:0016594 glycine binding
GO:0016933 extracellularly glycine-gated ion channel activity
GO:0016934 extracellularly glycine-gated chloride channel activity
GO:0016935 glycine-gated chloride channel complex
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0034220 ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0043200 response to amino acid
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0050877 nervous system process
GO:0060012 synaptic transmission, glycinergic
GO:0060013 righting reflex
GO:0097112 gamma-aminobutyric acid receptor clustering
GO:0098690 glycinergic synapse
GO:0098982 GABA-ergic synapse
GO:1902476 chloride transmembrane transport
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR008060 Glycine receptor betaFamilyFamily
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00145 GlycineDrugbanksmall molecule
DB00431 LindaneDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB05885 SeletracetamDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GLRB_HUMANGEPH_HUMANBioGRID, HPRD7546736 details
GLRB_HUMANA4_HUMANBioGRID21244100 details
GLRB_HUMANEPHA4_HUMANIntAct31413325 details